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![Processes for preparing pyrazolo[3,4-d]pyrimidine ethers](/abs-image/US/2008/09/16/US07425630B2/abs.jpg.150x150.jpg)
公开(公告)号：US07425630B2
公开(公告)日：2008-09-16
申请号：US11331372
申请日：2006-01-12
申请人： Tawfik Gharbaoui , Dipanjan Sengupta , Edward A. Lally , Naomi S. Kato , Marlon Carlos , Natalie Rodriguez
发明人： Tawfik Gharbaoui , Dipanjan Sengupta , Edward A. Lally , Naomi S. Kato , Marlon Carlos , Natalie Rodriguez
IPC分类号： C07D401/12 , C07D231/38
CPC分类号： C07D487/04
摘要： The present invention relates to processes for preparing pyrazolo[3,4-d]pyrimidine ether compounds that are modulators of glucose metabolism and therefore useful in the treatment of metabolic disorders such as diabetes and obesity.
摘要翻译： 本发明涉及制备作为葡萄糖代谢调节剂的吡唑并[3,4-d]嘧啶醚化合物的方法，因此可用于治疗代谢性疾病如糖尿病和肥胖症。
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2.发明授权Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto 有权某些3-苯基 - 吡唑衍生物的结晶形式作为5-HT2A 5-羟色胺受体的调节剂，可用于治疗与之相关的疾病公开(公告)号：US08980891B2
公开(公告)日：2015-03-17
申请号：US13516646
申请日：2010-12-16
申请人： Scott Stirn , Edward A. Lally
发明人： Scott Stirn , Edward A. Lally
IPC分类号： A61K31/5377 , C07D413/12 , C07D231/12
CPC分类号： C07D231/12
摘要： Provided are certain solvates of 3-methoxy-N-[3-(2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenyl]-benzamide or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions comprising such solvates and methods for their use.
摘要翻译： 提供了3-甲氧基-N- [3-（2-甲基-2H-吡唑-3-基）-4-（2-吗啉-4-基 - 乙氧基） - 苯基] - 苯甲酰胺或药学上可接受的某些溶剂合物 的盐。 还提供了包含这些溶剂化物的药物组合物及其使用方法。
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3.发明申请CRYSTALLINE FORMS OF CERTAIN 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 有权作为用于治疗相关疾病的5-HT2A丝氨酸受体的调节剂的某些3-苯基 - 吡唑衍生物的结晶形式公开(公告)号：US20120252813A1
公开(公告)日：2012-10-04
申请号：US13516646
申请日：2010-12-16
申请人： Scott Stirn , Edward A. Lally
发明人： Scott Stirn , Edward A. Lally
IPC分类号： A61K31/5377 , A61P7/02 , A61P3/10 , A61P9/10 , A61P11/06 , A61P25/18 , C07D413/12 , A61P9/00
CPC分类号： C07D231/12
摘要： Provided are certain solvates of 3-methoxy-N-[3-(2-methyl-2H-pyrazol-3-yl)-4-(2-morpholin-4-yl-ethoxy)-phenyl]-benzamide or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions comprising such solvates and methods for their use.
摘要翻译： 提供了3-甲氧基-N- [3-（2-甲基-2H-吡唑-3-基）-4-（2-吗啉-4-基 - 乙氧基） - 苯基] - 苯甲酰胺或药学上可接受的某些溶剂合物 的盐。 还提供了包含这些溶剂化物的药物组合物及其使用方法。
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公开(公告)号：US20080194836A1
公开(公告)日：2008-08-14
申请号：US11883043
申请日：2006-01-25
申请人： Tawfik Gharbaoui , Claudia Averbuj , Marlony Carlos , Edward A. Lally , Dipanjan Sengupta , John Robert Fritch
发明人： Tawfik Gharbaoui , Claudia Averbuj , Marlony Carlos , Edward A. Lally , Dipanjan Sengupta , John Robert Fritch
IPC分类号： C07D231/10
CPC分类号： C07D231/16
摘要： The present invention is directed to processes for the preparation of substituted phenylpyrazole ureas of Formula (I) that are useful as 5-HT2A serotonin receptor modulators for the treatment of disease.
摘要翻译： 本发明涉及制备式（I）的取代苯基吡唑脲的方法，其可用作治疗疾病的5-HT 2A 2 5-羟色胺受体调节剂。
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公开(公告)号：US08481535B2
公开(公告)日：2013-07-09
申请号：US12301212
申请日：2007-05-17
申请人： Tawfik Gharbaoui , Dipanjan Sengupta , Ashwin M. Krishnan , Nainesh Shah , Ryan M. Hart , Mark Macias , Edward A. Lally , Jonathan Duffield
发明人： Tawfik Gharbaoui , Dipanjan Sengupta , Ashwin M. Krishnan , Nainesh Shah , Ryan M. Hart , Mark Macias , Edward A. Lally , Jonathan Duffield
IPC分类号： A61K31/5377 , A61K31/496 , C07D295/185 , C07D403/12
CPC分类号： C07D231/12
摘要： The present invention relates to processes for preparing phenyl-pyrazoles of Formula (I) and salts and pharmaceutical compositions thereof, useful as modulators of 5-HT2A serotonin receptor activity. The present invention also relates to intermediates used in the processes, and their preparation. The present invention also relates to crystalline forms of 5-HT2A serotonin receptor modulators, compositions thereof and methods of using the same.
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![Processes for preparing substituted N-aryl-N′-[3-(1H-pyrazol-5-YL) phenyl] ureas and intermediates thereof](/abs-image/US/2010/10/12/US07812176B2/abs.jpg.150x150.jpg)
6.发明授权Processes for preparing substituted N-aryl-N′-[3-(1H-pyrazol-5-YL) phenyl] ureas and intermediates thereof 有权取代的N-芳基-N' - [3-（1H-吡唑-5-基）苯基]脲的制备方法及其中间体公开(公告)号：US07812176B2
公开(公告)日：2010-10-12
申请号：US10593847
申请日：2004-07-21
IPC分类号： C07D231/10
CPC分类号： C07D231/12 , C07C233/43 , C07D231/16
摘要： The present invention is directed to processes for the preparation of substituted phenylpyrazole ureas of Formula (I), that are useful as 5-HT2A serotonin receptor modulators for the treatment of disease.
摘要翻译： 本发明涉及制备式（I）的取代的苯基吡唑脲的方法，其可用作治疗疾病的5-HT2A 5-羟色胺受体调节剂。
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