摘要:
An inflatable tent assembly includes a trailer has a pair of wheels, a hitch and a body. The body has a plurality of storage compartments therein. The body has a front end, a back end, a first lateral side and a second lateral side. A generator is coupled to the trailer and the generator is positioned on the body. A blower is positioned in the trailer and the blower is positioned on the body. A tent is removably contained within the tent compartment and the tent is positionable on a support surface. The tent is selectively operationally coupled to the blower such that the blower inflates the tent into a standing position. Thus, the tent may be occupied.
摘要:
An inflatable tent assembly includes a trailer has a pair of wheels, a hitch and a body. The body has a plurality of storage compartments therein. The body has a front end, a back end, a first lateral side and a second lateral side. A generator is coupled to the trailer and the generator is positioned on the body. A blower is positioned in the trailer and the blower is positioned on the body. A tent is removably contained within the tent compartment and the tent is positionable on a support surface. The tent is selectively operationally coupled to the blower such that the blower inflates the tent into a standing position. Thus, the tent may be occupied.
摘要:
The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要:
An integrated solar cell system applies energy created by a solar cell module. The integration system includes a solar cell module, a low-grade heat recovery means, and a process system. The low-grade heat recovery means recovers waste heat from the solar cell module and connects the solar cell module to the process system. The process system is powered at least partially by thermal energy derived from waste heat generated by the solar cell module.
摘要:
The invention relates to γ-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要:
The invention relates to linear γ-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvillsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要:
This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more &ggr;-carboxyglutamate residues. More specifically, the present invention is directed to &ggr;-conopeptides having the general formula I: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7 (SEQ ID NO:1), as described herein; or having the general formula II: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8 (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7 (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:4), as described herein; or having the general formula V: Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa8-Leu-Xaa9 (SEQ ID NO:5), as described herein. The invention further relates to specific &ggr;-conopeptides, specific pro-&ggr;-conopeptides and nucleic acids encoding the pro-&ggr;-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.
摘要翻译:本发明涉及长度约25-40个残基的相对较短的肽,其在锥形蜗牛的毒液中或天然存在的肽的类似物中天然可用量少,并且其包括三个环化二硫键和一个或多个γ- 羧基谷氨酸残基。 更具体地,本发明涉及具有通式I的X射线衍生肽:Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7(SEQ ID NO:1) ,如本文所述; 或具有如本文所定义的通式II:Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8(SEQ ID NO:2) 或具有通式III:Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7(SEQ ID NO:3) 在这里 或具有通式IV:Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7(SEQ ID NO:4) 在这里 或具有通式V:Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr -Cys-Xaa8-Leu-Xaa9(SEQ ID NO:5),如本文所述。 本发明进一步涉及具体的γ-配体肽,特异性前-γ-肽和编码前γ-多肽的核酸。 本发明还包括肽的药学上可接受的盐。 这些肽可用作神经元起搏器钙通道的激动剂。
摘要:
The materials of adjoining porous metal substrate (12), oxide (14), and Pd-alloy membrane (16) layers of a composite, H2—separation palladium membrane (10) have respective thermal expansion coefficients (TEC) which differ from one another so little as to resist failure by TEC mismatch from thermal cycling. TEC differences (20, 22) of less than 3 μm/(m.k) between materials of adjacent layers are achieved by a composite system of a 446 stainless steel substrate, an oxide layer of 4 wt % yittria-zirconia, and a 77 wt % Pd-23 wt % Ag or 60 wt % Pd-40 wt % Cu, membrane, having TECs of 11, 11, and 13.9 μm/(m.k), respectively. The Intermediate oxide layer comprises particles forming pores having an average pore sizeless than 5 microns, and preferably less than about 3 microns, in thickness.
摘要:
A Faraday system for measuring ion beam current in an ion implanter or other ion beam treatment system includes a Faraday cup body defining a chamber which has an entrance aperture for receiving an ion beam, a suppression electrode positioned in proximity to the entrance aperture to produce electric fields for inhibiting escape of electrons from the chamber, and a magnet assembly positioned to produce magnetic fields for inhibiting escape of electrons from the chamber. The chamber may have a relatively small ratio of chamber depth to entrance aperture width.
摘要:
The invention relates to relatively short peptides (termed &tgr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.