公开(公告)号：US09526429B2

公开(公告)日：2016-12-27

申请号：US12367255

申请日：2009-02-06

Applicant: Conor Heneghan ,  Alberto Zaffaroni ,  Philip De Chazal ,  Redmond Shouldice

Inventor： Conor Heneghan ,  Alberto Zaffaroni ,  Philip De Chazal ,  Redmond Shouldice

IPC: G06F19/00 ,  A61B5/00 ,  A61B5/0205 ,  G01S13/50 ,  A61B5/08 ,  A61B5/113

CPC classification number: A61B5/0205 ,  A61B5/024 ,  A61B5/0507 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/411 ,  A61B5/4818 ,  A61B5/7264 ,  A61B5/7282 ,  A61B5/742 ,  G01S13/50 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

Abstract: An apparatus, system, and method for monitoring a person suffering from a chronic medical condition predicts and assesses physiological changes which could affect the care of that subject. Examples of such chronic diseases include (but are not limited to) heart failure, chronic obstructive pulmonary disease, asthma, and diabetes. Monitoring includes measurements of respiratory movements, which can then be analyzed for evidence of changes in respiratory rate, or for events such as hypoponeas, apneas and periodic breathing. Monitoring may be augmented by the measurement of nocturnal heart rate in conjunction with respiratory monitoring. Additional physiological measurements can also be taken such as subjective symptom data, blood pressure, blood oxygen levels, and various molecular markers. Embodiments for detection of respiratory patterns and heart rate are disclosed, together with exemplar implementations of decision processes based on these measurements.

Abstract translation: 用于监测患有慢性医学病症的人的装置，系统和方法预测和评估可能影响该受试者照顾的生理变化。 这些慢性疾病的实例包括（但不限于）心力衰竭，慢性阻塞性肺疾病，哮喘和糖尿病。 监测包括呼吸运动的测量，然后可以分析其呼吸频率变化的证据，或用于hypoponeas，呼吸暂停和定期呼吸等事件。 监测可以通过与呼吸监测结合的夜间心率的测量来增强。 还可以进行额外的生理测量，例如主观症状数据，血压，血氧水平和各种分子标记。 公开了用于检测呼吸模式和心率的实施例以及基于这些测量的决策过程的示例性实现。

公开(公告)号：US08834364B2

公开(公告)日：2014-09-16

申请号：US12376771

申请日：2007-10-31

Applicant: Conor Heneghan ,  Conor Hanley ,  Philip De Chazal

Inventor： Conor Heneghan ,  Conor Hanley ,  Philip De Chazal

IPC: G06F19/00 ,  A61B5/11 ,  A61B5/0205 ,  A61B5/113 ,  A61B5/05 ,  A61B5/00

CPC classification number: A61B5/0205 ,  A61B5/0507 ,  A61B5/1102 ,  A61B5/113 ,  A61B5/6802 ,  A61B5/681 ,  A61B5/6895

Abstract: An apparatus, system, and method is disclosed for monitoring the motion, breathing, heart rate of humans in a convenient and low-cost fashion, and for deriving and displaying useful measurements of cardiorespiratory performance from the measured signals. The motion, breathing, and heart rate signals are obtained through a processing applied to a raw signal obtained in a non-contact fashion, typically using a radio-frequency sensor. Processing into separate cardiac and respiratory components is described. The heart rate can be determined by using either spectral or time-domain processing. The respiratory rate can be calculated using spectral analysis. Processing to derive the heart rate, respiratory sinus arrhythmia, or a ventilatory threshold parameter using the system is described. The sensor, processing, and display can be incorporated in a single device which can be worn or held close to the body while exercising (e.g., in a wristwatch or mobile phone configuration), or alternately placed in a fixed piece of exercise equipment at some distance form the body (e.g., in a treadmill dash panel), and may also be integrated with other sensors, such as position locators.

Abstract translation: 公开了一种用于以便利和低成本方式监测人的运动，呼吸，心率以及用于从所测量的信号导出和显示心肺功能的有用测量值的装置，系统和方法。 通过应用于以非接触方式获得的原始信号的处理（通常使用射频传感器）获得运动，呼吸和心率信号。 描述了处理成单独的心脏和呼吸成分。 心率可以通过光谱或时域处理来确定。 可以使用光谱分析计算呼吸频率。 描述了使用该系统导出心率，呼吸窦性心律失常或通气阈值参数的处理。 传感器，处理和显示器可以结合在单个装置中，其可以在锻炼（例如，在手表或手机配置中）时佩戴或保持靠近身体，或者交替地放置在固定的一些锻炼设备中 距离身体（例如，在跑步机仪表板中），并且还可以与诸如位置定位器的其它传感器集成。

公开(公告)号：US20110178377A1

公开(公告)日：2011-07-21

申请号：US13120640

申请日：2009-09-23

Applicant: Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Alberto Zaffaroni ,  Philip De Chazal

Inventor： Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Alberto Zaffaroni ,  Philip De Chazal

IPC: A61B5/00

CPC classification number: G06F19/3431 ,  A61B5/0002 ,  A61B5/4806 ,  A61B5/4815 ,  A61B5/72 ,  A61B5/7271 ,  A61B5/74 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/36 ,  G16H10/20 ,  G16H50/20 ,  G16H50/30

Abstract: An apparatus, system, and method for the measurement, aggregation and analysis of data collected using non-contact or minimally-contacting sensors provides quality of life parameters for individual subjects, particularly in the context of a controlled trial of interventions on human subjects (e.g., a clinical trial of a drug, or an evaluation of a consumer item such as a fragrance). In particular, non-contact or minimal-contact measurement of quality-of-life parameters such as sleep, stress, relaxation, drowsiness, temperature and emotional state of humans may be evaluated, together with automated sampling, storage, and transmission to a remote data analysis center. One component of the system is that the objective data is measured with as little disruption as possible to the normal behavior of the subject. The system can also support behavioral and pharmaceutical interventions aimed at improving quality of life.

Abstract translation: 用于使用非接触或最小接触传感器收集的数据的测量，聚集和分析的装置，系统和方法提供个体受试者的生活质量参数，特别是在对受试者的干预措施的对照试验（例如， ，药物的临床试验，或消费品如香料的评估）。 特别地，可以评估生活质量参数（例如睡眠，压力，放松，嗜睡，温度和人类的情绪状态）的非接触或最小接触测量，以及自动采样，存储和传输到远程 数据分析中心。 该系统的一个组成部分是测量客观数据，尽可能少地破坏主体的正常行为。 该系统还可以支持旨在提高生活质量的行为和药物干预措施。

公开(公告)号：US20110124979A1

公开(公告)日：2011-05-26

申请号：US12674344

申请日：2008-08-11

Applicant: Conor Heneghan ,  Eric C.-P. Chua ,  Gareth Mcdarby

Inventor： Conor Heneghan ,  Eric C.-P. Chua ,  Gareth Mcdarby

IPC: A61B5/00

CPC classification number: A61B5/024 ,  A61B5/02405 ,  A61B5/04012 ,  A61B5/4812 ,  A61B5/4818

Abstract: A method of monitoring sleep comprises simultaneously recording a person's electrocardiogram (ECG) and photoplethysmogram (PPG), deriving a plurality of parameters from the recorded data, and providing an output indicative of a sleep characteristic based upon an analysis of the parameters. The ECG and PPG may be recorded using an apparatus which is a combination of a Holter monitor and a pulse oximeter, which is wearable in ambulatory manner.

Abstract translation: 监测睡眠的方法包括同时记录人的心电图（ECG）和光谱运动图（PPG），从记录的数据中导出多个参数，以及基于参数的分析来提供表示睡眠特征的输出。 可以使用作为动态心电图监视器和脉搏血氧计的组合的装置来记录ECG和PPG，该装置可以步态穿戴。

公开(公告)号：US08562526B2

公开(公告)日：2013-10-22

申请号：US12302704

申请日：2007-06-01

Applicant: Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Philip De Chazal

Inventor： Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Philip De Chazal

IPC: A61B5/00

CPC classification number: A61B5/0205 ,  A61B5/0507 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/4818 ,  A61B5/7264

Abstract: An apparatus, system, and method monitors the motion, breathing, heart rate and sleep state of subjects, e.g., humans, in a convenient, non-invasive/non-contact, and low-cost fashion. More particularly, the motion, breathing, and heart rate signals are obtained through processing applied to a raw signal obtained in a non-contact fashion, typically using a radio-frequency sensor. Periods of sleep disturbed respiration, or central apnea can be detected through analysis of the respiratory signal. The mean heart rate, and derived information, such as the presence of cardiac arrhythmias can be determined from the cardiac signal. Motion estimates can be used to recognize disturbed sleep and periodic limb movements. The sleep state may be determined by applying a classifier model to the resulting streams of respiratory, cardiac and motion data. A means for display of the sleep state, respiratory, cardiac, and movement status may also be provided.

Abstract translation: 装置，系统和方法以方便，非侵入/非接触和低成本的方式监测受试者（例如人）的运动，呼吸，心率和睡眠状态。 更具体地，通过应用于以非接触方式获得的原始信号的处理（通常使用射频传感器）获得运动，呼吸和心率信号。 睡眠期间呼吸紊乱或中枢性呼吸暂停可以通过分析呼吸信号进行检测。 可以从心脏信号中确定平均心率和派生信息，例如心律不齐的存在。 运动估计可用于识别受扰的睡眠和周期性肢体运动。 可以通过将分类器模型应用于所得到的呼吸，心脏和运动数据流来确定睡眠状态。 还可以提供用于显示睡眠状态，呼吸，心脏和运动状态的装置。

公开(公告)号：US07862515B2

公开(公告)日：2011-01-04

申请号：US11308429

申请日：2006-03-24

Applicant: Philip de Chazal ,  Conor Heneghan ,  Elaine Sheridan

Inventor： Philip de Chazal ,  Conor Heneghan ,  Elaine Sheridan

IPC: A61B5/0402

CPC classification number: A61B5/4818 ,  A61B5/04325 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7264 ,  A61B5/7267 ,  G06F19/00 ,  G16H50/20

Abstract: An apparatus for diagnosing sleep apnea only uses an electrocardiogram signal and a computer processor and associated computer code that are configured to analyze the electrocardiogram signal and classify each time period of the electrocardiogram signal as either apneic or normal. A diagnostic measure of sleep apnea for the human patient is provided based on classification results obtained by combining a results for various electrocardiogram signal time periods. A computer-readable medium has computer code that causes the computer to analyze an electrocardiogram signal relating to the human patient and classify each time period in a set of time periods as either apneic or normal. A diagnostic measure of sleep apnea is provided based on classification results obtained by combining a plurality of results from the set of time periods using either time or frequency domain processing, or both.

Abstract translation: 用于诊断睡眠呼吸暂停的装置仅使用心电图信号和计算机处理器以及相关联的计算机代码，其被配置为分析心电图信号并将心电图信号的每个时间段分类为呼吸暂停或正常。 基于通过组合各种心电图信号时间段的结果而获得的分类结果，提供了针对人类患者的睡眠呼吸暂停的诊断测量。 计算机可读介质具有计算机代码，该计算机代码使得计算机分析与人类患者有关的心电图信号，并且在一组时间段内将呼吸暂停或正常的每个时间段分类。 基于通过使用时间或频域处理组合来自所述一组时间段的多个结果或两者来获得的分类结果来提供睡眠呼吸暂停的诊断测量。

公开(公告)号：US20100179438A1

公开(公告)日：2010-07-15

申请号：US12376771

申请日：2007-10-31

Applicant: Conor Heneghan ,  Conor Hanley ,  Philip De Chazal

Inventor： Conor Heneghan ,  Conor Hanley ,  Philip De Chazal

IPC: A61B5/0205 ,  A61B5/11

CPC classification number: A61B5/0205 ,  A61B5/0507 ,  A61B5/1102 ,  A61B5/113 ,  A61B5/6802 ,  A61B5/681 ,  A61B5/6895

Abstract: An apparatus, system, and method is disclosed for monitoring the motion, breathing, heart rate of humans in a convenient and low-cost fashion, and for deriving and displaying useful measurements of cardiorespiratory performance from the measured signals. The motion, breathing, and heart rate signals are obtained through a processing applied to a raw signal obtained in a non-contact fashion, typically using a radio-frequency sensor. Processing into separate cardiac and respiratory components is described. The heart rate can be determined by using either spectral or time-domain processing. The respiratory rate can be calculated using spectral analysis. Processing to derive the heart rate, respiratory sinus arrhythmia, or a ventilatory threshold parameter using the system is described. The sensor, processing, and display can be incorporated in a single device which can be worn or held close to the body while exercising (e.g., in a wristwatch or mobile phone configuration), or alternately placed in a fixed piece of exercise equipment at some distance form the body (e.g., in a treadmill dash panel), and may also be integrated with other sensors, such as position locators.

Abstract translation: 公开了一种用于以便利和低成本方式监测人的运动，呼吸，心率以及用于从所测量的信号导出和显示心肺功能的有用测量值的装置，系统和方法。 通过应用于以非接触方式获得的原始信号的处理（通常使用射频传感器）获得运动，呼吸和心率信号。 描述了处理成单独的心脏和呼吸成分。 心率可以通过光谱或时域处理来确定。 可以使用光谱分析计算呼吸频率。 描述了使用该系统导出心率，呼吸窦性心律失常或通气阈值参数的处理。 传感器，处理和显示器可以结合在单个装置中，其可以在锻炼（例如，在手表或手机配置中）时佩戴或保持靠近身体，或者交替地放置在固定的一些锻炼设备中 距离身体（例如，在跑步机仪表板中），并且还可以与诸如位置定位器的其它传感器集成。

公开(公告)号：US09223935B2

公开(公告)日：2015-12-29

申请号：US13120640

申请日：2009-09-23

Applicant: Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Alberto Zaffaroni ,  Philip De Chazal

Inventor： Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Alberto Zaffaroni ,  Philip De Chazal

IPC: A61B5/00 ,  G06F19/00

CPC classification number: G06F19/3431 ,  A61B5/0002 ,  A61B5/4806 ,  A61B5/4815 ,  A61B5/72 ,  A61B5/7271 ,  A61B5/74 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/36 ,  G16H10/20 ,  G16H50/20 ,  G16H50/30

Abstract: An apparatus, system, and method for the measurement, aggregation and analysis of data collected using non-contact or minimally-contacting sensors provides quality of life parameters for individual subjects, particularly in the context of a controlled trial of interventions on human subjects (e.g., a clinical trial of a drug, or an evaluation of a consumer item such as a fragrance). In particular, non-contact or minimal-contact measurement of quality-of-life parameters such as sleep, stress, relaxation, drowsiness, temperature and emotional state of humans may be evaluated, together with automated sampling, storage, and transmission to a remote data analysis center. One component of the system is that the objective data is measured with as little disruption as possible to the normal behavior of the subject. The system can also support behavioral and pharmaceutical interventions aimed at improving quality of life.

Abstract translation: 用于使用非接触或最小接触传感器收集的数据的测量，聚集和分析的装置，系统和方法提供个体受试者的生活质量参数，特别是在对受试者的干预措施的对照试验（例如， ，药物的临床试验，或消费品如香料的评估）。 特别地，可以评估生活质量参数（例如睡眠，压力，放松，嗜睡，温度和人类的情绪状态）的非接触或最小接触测量，以及自动采样，存储和传输到远程 数据分析中心。 该系统的一个组成部分是测量客观数据，尽可能少地破坏主体的正常行为。 该系统还可以支持旨在提高生活质量的行为和药物干预措施。

公开(公告)号：US20100152543A1

公开(公告)日：2010-06-17

申请号：US12565371

申请日：2009-09-23

Applicant: Conor HENEGHAN ,  Conor HANLEY ,  Niall FOX ,  Alberto ZAFFARONI ,  Philip DE CHAZAL

Inventor： Conor HENEGHAN ,  Conor HANLEY ,  Niall FOX ,  Alberto ZAFFARONI ,  Philip DE CHAZAL

IPC: A61B5/00

Abstract: An apparatus, system, and method for the measurement, aggregation and analysis of data collected using non-contact or minimally-contacting sensors provides quality of life parameters for individual subjects, particularly in the context of a controlled trial of interventions on human subjects (e.g., a clinical trial of a drug, or an evaluation of a consumer item such as a fragrance). In particular, non-contact or minimal-contact measurement of quality-of-life parameters such as sleep, stress, relaxation, drowsiness, temperature and emotional state of humans may be evaluated, together with automated sampling, storage, and transmission to a remote data analysis center. One component of the system is that the objective data is measured with as little disruption as possible to the normal behavior of the subject. The system can also support behavioral and pharmaceutical interventions aimed at improving quality of life.

Abstract translation: 用于使用非接触或最小接触传感器收集的数据的测量，聚集和分析的装置，系统和方法提供个体受试者的生活质量参数，特别是在对受试者的干预措施的对照试验（例如， ，药物的临床试验，或消费品如香料的评估）。 特别地，可以评估生活质量参数（例如睡眠，压力，放松，嗜睡，温度和人类的情绪状态）的非接触或最小接触测量，以及自动采样，存储和传输到远程 数据分析中心。 该系统的一个组成部分是测量客观数据，尽可能少地破坏主体的正常行为。 该系统还可以支持旨在提高生活质量的行为和药物干预措施。

公开(公告)号：US20090203972A1

公开(公告)日：2009-08-13

申请号：US12302704

申请日：2007-06-01

Applicant: Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Philip De Chazal

Inventor： Conor Heneghan ,  Conor Hanley ,  Niall Fox ,  Philip De Chazal

IPC: A61B5/00

CPC classification number: A61B5/0205 ,  A61B5/0507 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/4818 ,  A61B5/7264

Abstract: An apparatus, system, and method monitors the motion, breathing, heart rate and sleep state of subjects, e.g., humans, in a convenient, non-invasive/non-contact, and low-cost fashion. More particularly, the motion, breathing, and heart rate signals are obtained through processing applied to a raw signal obtained in a non-contact fashion, typically using a radio-frequency sensor. Periods of sleep disturbed respiration, or central apnea can be detected through analysis of the respiratory signal. The mean heart rate, and derived information, such as the presence of cardiac arrhythmias can be determined from the cardiac signal. Motion estimates can be used to recognize disturbed sleep and periodic limb movements. The sleep state may be determined by applying a classifier model to the resulting streams of respiratory, cardiac and motion data. A means for display of the sleep state, respiratory, cardiac, and movement status may also be provided.

Abstract translation: 装置，系统和方法以方便，非侵入/非接触和低成本的方式监测受试者（例如人）的运动，呼吸，心率和睡眠状态。 更具体地，通过应用于以非接触方式获得的原始信号的处理（通常使用射频传感器）获得运动，呼吸和心率信号。 睡眠期间呼吸紊乱或中枢性呼吸暂停可以通过分析呼吸信号进行检测。 可以从心脏信号中确定平均心率和派生信息，例如心律不齐的存在。 运动估计可用于识别受扰的睡眠和周期性肢体运动。 可以通过将分类器模型应用于所得到的呼吸，心脏和运动数据流来确定睡眠状态。 还可以提供用于显示睡眠状态，呼吸，心脏和运动状态的装置。