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1.发明公开公开(公告)号：US20240360162A1
公开(公告)日：2024-10-31
申请号：US18767494
申请日：2024-07-09
发明人： Derek John LONDESBROUGH , Christopher BROWN , Julian Scott NORTHEN , Gillian MOORE , Hemant Kashinath PATIL , David E. NICHOLS
CPC分类号： C07F9/5728 , A61K9/0053 , A61K9/2054 , A61K47/36 , A61K47/38 , C07D209/16 , C07B2200/13
摘要： This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
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2.发明公开公开(公告)号：US20240252521A1
公开(公告)日：2024-08-01
申请号：US18522440
申请日：2023-11-29
发明人： Derek John LONDESBROUGH , Christopher BROWN , Julian Scott NORTHEN , Gillian MOORE , Hemant Kashinath PATIL , David E. NICHOLS , Megan CROAL , Hans Åke ERIKSSON , George GOLDSMITH , Molly Tabitha HICKEY , Shaun HURLEY , Ekaterina MALIEVSKAIA , Lindsey MARWOOD , Drummond E-Wen Joe MCCULLOCH , Laurie Emma MEDHURST , Nathan POULSEN , Aslihan SELIMBEYOGLU , Anaïs SOULA , Amanda Tan SHUXIANG , Manon Cecile Elisabeth VERAART , Tobias Patrick WHELAN , Lars Christian WILDE , Stephen WRIGHT
IPC分类号： A61K31/675 , A61K9/00 , A61K9/20 , A61K9/48 , A61K31/661 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07F9/572
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , A61K31/661 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07F9/5728 , C07B2200/13
摘要： The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
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3.发明公开公开(公告)号：US20240199660A1
公开(公告)日：2024-06-20
申请号：US18433051
申请日：2024-02-05
发明人： Derek John LONDESBROUGH , Christopher BROWN , Julian Scott NORTHEN , Gillian MOORE , Hemant Kashinath PATIL , David E. NICHOLS
CPC分类号： C07F9/5728 , A61K9/0053 , A61K9/2054 , A61K47/36 , A61K47/38 , C07D209/16 , C07B2200/13
摘要： This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
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公开(公告)号：US20240197758A1
公开(公告)日：2024-06-20
申请号：US18285109
申请日：2022-03-30
IPC分类号： A61K31/661 , A61K9/20 , A61K9/48
CPC分类号： A61K31/661 , A61K9/2059 , A61K9/4833 , A61K9/4866
摘要： The present disclosure provides pharmaceutical compositions comprising a therapeutically effective amount of psilocybin and one or more pharmaceutically acceptable excipients. Methods of making such compositions and use thereof in treating depressive disorders are also disclosed.
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5.发明公开公开(公告)号：US20230330117A1
公开(公告)日：2023-10-19
申请号：US18210526
申请日：2023-06-15
发明人： Derek John LONDESBROUGH , Christopher BROWN , Julian Scott NORTHEN , Gillian MOORE , Hemant Kashinath PATIL , David E. NICHOLS , Megan CROAL , Hans Åke ERIKSSON , George GOLDSMITH , Molly Tabitha HICKEY , Shaun HURLEY , Ekaterina MALIEVSKAIA , Lindsey MARWOOD , Drummond E-Wen Joe MCCULLOCH , Laurie Emma MEDHURST , Nathan POULSEN , Aslihan SELIMBEYOGLU , Anaïs SOULA , Amanda Tan SHUXIANG , Manon Cecile Elisabeth VERAART , Tobias Patrick WHELAN , Lars Christian WILDE , Stephen WRIGHT
IPC分类号： A61K31/675 , A61P25/00 , A61P25/20 , A61P25/28 , A61P25/22 , A61P25/04 , A61P25/08 , A61P25/16 , C07F9/572 , A61K9/00 , A61K9/20 , A61K9/48 , A61K31/661 , A61P25/24
CPC分类号： A61K31/675 , A61P25/00 , A61P25/20 , A61P25/28 , A61P25/22 , A61P25/04 , A61P25/08 , A61P25/16 , C07F9/5728 , A61K9/0053 , A61K9/20 , A61K9/48 , A61K31/661 , A61P25/24 , C07B2200/13
摘要： The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
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公开(公告)号：US11661617B2
公开(公告)日：2023-05-30
申请号：US17012737
申请日：2020-09-04
发明人： Ryan Protzko
IPC分类号： C12P17/10 , A61K31/4045 , C07D209/16 , C12N9/02 , C12N9/12 , C12N9/88 , C12N9/10
CPC分类号： C12P17/10 , A61K31/4045 , C07D209/16 , C12N9/0042 , C12N9/0071 , C12N9/0083 , C12N9/1205 , C12N9/88 , C12Y106/02004 , C12Y114/16004 , C12Y114/99 , C12Y207/01 , C12Y401/01
摘要： Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.
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公开(公告)号：US20230023092A1
公开(公告)日：2023-01-26
申请号：US17604610
申请日：2020-04-17
发明人： Derek John LONDESBROUGH , Christopher BROWN , Julian Scott NORTHEN , Gillian MOORE , Hemant Kashinath PATIL , David E. NICHOLS , Megan CROAL , Hans Ake ERIKSSON , George GOLDSMITH , Molly Tabitha HICKEY , Shaun HURLEY , Ekaterina MALIEVSKAIA , Lindsey MARWOOD , Drummond E-Wen Joe MCCULLOCH , Laurie Emma MEDHURST , Nathan POULSEN , Aslihan SELIMBEYOGLU , Anais SOULA , Amanda Tan SHUXIANG , Manon Cecile Elisabeth VERAART , Tobias Patrick WHELAN , Lars Christian WILDE , Stephen WRIGHT
摘要： The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat depression, neurocognitive disorders, autism spectrum disorder, and/or attention-deficit/hyperactivity disorder.
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8.发明申请公开(公告)号：US20220088041A1
公开(公告)日：2022-03-24
申请号：US17540962
申请日：2021-12-02
发明人： Derek John LONDESBROUGH , Christopher BROWN , Julian Scott NORTHEN , Gillian MOORE , Hemant Kashinath PATIL , David E. NICHOLS , Megan CROAL , Hans Åke ERIKSSON , George GOLDSMITH , Molly Tabitha HICKEY , Shaun HURLEY , Ekaterina MALIEVSKAIA , Lindsey MARWOOD , Drummond E-Wen Joe MCCULLOCH , Laurie Emma MEDHURST , Nathan POULSEN , Aslihan SELIMBEYOGLU , Anaïs SOULA , Amanda Tan SHUXIANG , Manon Cecile Elisabeth VERAART , Tobias Patrick WHELAN , Lars Christian WILDE , Stephen WRIGHT
IPC分类号： A61K31/675 , A61P25/00
摘要： The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
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公开(公告)号：US20240269113A1
公开(公告)日：2024-08-15
申请号：US18420562
申请日：2024-01-23
发明人： John Richard MORPHY
IPC分类号： A61K31/4045 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/695 , C07D209/14 , C07D401/12 , C07D403/12 , C07D417/12 , C07F7/08
CPC分类号： A61K31/4045 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/695 , C07D209/14 , C07D401/12 , C07D403/12 , C07D417/12 , C07F7/0812
摘要： Provided herein are compounds of Formula (I)
(I), a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or Table 5, or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R1 and R4 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I), or a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or Table 5, or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I) or pharmaceutically acceptable salt or deuterated form thereof, e.g., in treating 5-HT2A receptor associated diseases or disorders.-
10.发明授权公开(公告)号：US11851451B2
公开(公告)日：2023-12-26
申请号：US17990979
申请日：2022-11-21
发明人： Derek John Londesbrough , Christopher Brown , Julian Scott Northen , Gillian Moore , Hemant Kashinath Patil , David E. Nichols
CPC分类号： C07F9/5728 , A61K9/0053 , A61K9/2054 , A61K47/36 , A61K47/38 , C07D209/16 , C07B2200/13
摘要： This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.
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