公开(公告)号：US20110201594A1

公开(公告)日：2011-08-18

申请号：US12311843

申请日：2008-10-16

Applicant: Krisna Murthi ,  Rebecca Casaubon ,  Arthur F. Kluge ,  Chase Smith ,  Joachim Vogt

Inventor： Krisna Murthi ,  Rebecca Casaubon ,  Arthur F. Kluge ,  Chase Smith ,  Joachim Vogt

IPC: A61K31/519 ,  C07D471/04 ,  A61K31/5377 ,  A61K31/551 ,  A61P35/00 ,  C12N5/09

CPC classification number: C07D471/04

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract translation: 本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。 这些化合物是激酶抑制剂，包括显示抗增殖活性的化合物，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：US08232283B2

公开(公告)日：2012-07-31

申请号：US13105957

申请日：2011-05-12

Applicant: Andreas Schoop ,  Alexander Backes ,  Joachim Vogt ,  Lars Neumann ,  Jan Eickhoff ,  Stefan Hannus ,  Kerrin Hansen ,  Peter Amon ,  Igor Ivanov ,  Matthias Borgmann ,  Chase Smith ,  Arthur F. Kluge ,  Krishan Murthi ,  Rebecca Casaubon

Inventor： Andreas Schoop ,  Alexander Backes ,  Joachim Vogt ,  Lars Neumann ,  Jan Eickhoff ,  Stefan Hannus ,  Kerrin Hansen ,  Peter Amon ,  Igor Ivanov ,  Matthias Borgmann ,  Chase Smith ,  Arthur F. Kluge ,  Krishan Murthi ,  Rebecca Casaubon

IPC: C07D471/04 ,  A61K31/505 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract translation: 本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。 这些化合物是抑制剂或激酶如Raf，包括显示抗增殖活性的化合物，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：US06861537B2

公开(公告)日：2005-03-01

申请号：US10194347

申请日：2002-07-12

Applicant: Robert A. Holton ,  Carmen Somoza ,  Hyeong Baik Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

Inventor： Robert A. Holton ,  Carmen Somoza ,  Hyeong Baik Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

IPC: C07C69/00 ,  C07D305/14 ,  C07D307/935 ,  C07D317/72 ,  C07D493/10 ,  C07D317/70

CPC classification number: C07D307/935 ,  C07D305/14 ,  C07D317/72 ,  C07D493/10 ,  C07F7/1804

Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.

Abstract translation: 紫杉醇等三环和四环紫杉烷的合成。

公开(公告)号：US20140163003A1

公开(公告)日：2014-06-12

申请号：US13949495

申请日：2013-07-24

Applicant: KRISHNA MURTHI ,  REBECCA CASAUBON ,  ARTHUR F. KLUGE ,  CHASE SMITH ,  JOACHIM VOGT

Inventor： KRISHNA MURTHI ,  REBECCA CASAUBON ,  ARTHUR F. KLUGE ,  CHASE SMITH ,  JOACHIM VOGT

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

公开(公告)号：US20080200523A1

公开(公告)日：2008-08-21

申请号：US11708793

申请日：2007-02-21

Applicant: Krishna K. Murthi ,  Roland Kostler ,  Chase Smith ,  Tilman Brandstetter ,  Arthur F. Kluge

Inventor： Krishna K. Murthi ,  Roland Kostler ,  Chase Smith ,  Tilman Brandstetter ,  Arthur F. Kluge

IPC: A61K31/44 ,  A61P35/00 ,  C07D213/74 ,  C12N5/00

CPC classification number: C07D213/74 ,  C07D401/12 ,  C12N5/0693 ,  C12N2501/06

Abstract: The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract translation: 本发明提供方酸的衍生物，特别是3,4-二氨基 - 环丁-3-烯-1,2-二酮及其互变异构体及其异构体的衍生物作为单一立体异构体或立体异构体的混合物，或作为药学上可接受的盐 其可接受的盐。 这些化合物显示抗增殖活性，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：US5637732A

公开(公告)日：1997-06-10

申请号：US383775

申请日：1995-02-06

Applicant: Robert A. Holton ,  Carmen Somoza ,  Hyeong B. Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

Inventor： Robert A. Holton ,  Carmen Somoza ,  Hyeong B. Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

IPC: C07D317/36 ,  C07C49/733 ,  C07C69/00 ,  C07C69/608 ,  C07C69/757 ,  C07D305/14 ,  C07D307/93 ,  C07D307/935 ,  C07D317/72 ,  C07D319/08 ,  C07D493/10 ,  C07F7/18

CPC classification number: C07D307/935 ,  C07D305/14 ,  C07D307/93 ,  C07D317/72 ,  C07D493/10

Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.

Abstract translation: 紫杉醇等三环和四环紫杉烷的合成。

公开(公告)号：US5405972A

公开(公告)日：1995-04-11

申请号：US189058

申请日：1994-01-27

Applicant: Robert A. Holton ,  Carmen Somoza ,  Hyeong B. Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

Inventor： Robert A. Holton ,  Carmen Somoza ,  Hyeong B. Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

IPC: C07D317/36 ,  C07C49/733 ,  C07C69/00 ,  C07C69/608 ,  C07C69/757 ,  C07D305/14 ,  C07D307/93 ,  C07D307/935 ,  C07D317/72 ,  C07D319/08 ,  C07D493/10 ,  C07F7/18 ,  C07D317/70

CPC classification number: C07D307/935 ,  C07D305/14 ,  C07D307/93 ,  C07D317/72 ,  C07D493/10

Abstract: Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.

Abstract translation: 紫杉醇和其他三环和四环紫杉烷的合成方法。

公开(公告)号：US20210290229A1

公开(公告)日：2021-09-23

申请号：US16826355

申请日：2020-03-23

Applicant: Chase Smith

Inventor： Chase Smith

IPC: A61B17/06 ,  A61B50/18 ,  A61B50/13

Abstract: The present disclosure relates to a suture inventory management device that stores and dispenses individual units of sutures from a first compartment and stores boxes of units of sutures of the same type of sutures in a second compartment. In some embodiments, the suture inventory management device is a suture storage cart comprising suture storage systems. The suture storage systems including at least one pair of suture storage compartments, the pair of suture storage compartments comprising a bulk suture storage compartment and a suture unit storage compartment. Units of sutures are stored in the suture unit storage compartment and boxes of the same type of sutures are stored in the corresponding bulk suture storage compartments. The interior of the suture unit storage compartment has a hinged top lid transparent door that opens by sliding vertically and the bulk suture storage compartments are enclosed by transparent doors.

公开(公告)号：US20110257207A1

公开(公告)日：2011-10-20

申请号：US13105957

申请日：2011-05-12

Applicant: Alexander BACKES ,  Joachim VOGT ,  Peter AMON ,  Igor IVANOV ,  Stefan HANNUS ,  Matthias BORGMANN ,  Kerrin HANSEN ,  Rebecca CASAUBON ,  Chase SMITH ,  Krishna MURTHI ,  Arthur KLUGE ,  Andreas SCHOOP ,  Lars NEUMANN ,  Jan EICKHOFF

Inventor： Alexander BACKES ,  Joachim VOGT ,  Peter AMON ,  Igor IVANOV ,  Stefan HANNUS ,  Matthias BORGMANN ,  Kerrin HANSEN ,  Rebecca CASAUBON ,  Chase SMITH ,  Krishna MURTHI ,  Arthur KLUGE ,  Andreas SCHOOP ,  Lars NEUMANN ,  Jan EICKHOFF

IPC: A61K31/519 ,  A61P35/00 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract translation: 本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。 这些化合物是抑制剂或激酶如Raf，包括显示抗增殖活性的化合物，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：US06278026B1

公开(公告)日：2001-08-21

申请号：US09333382

申请日：1999-06-15

Applicant: Robert A. Holton ,  Carmen Somoza ,  Hyeong Baik Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

Inventor： Robert A. Holton ,  Carmen Somoza ,  Hyeong Baik Kim ,  Mitsuru Shindo ,  Ronald J. Biediger ,  P. Douglas Boatman ,  Chase Smith ,  Feng Liang ,  Krishna Murthi

IPC: C07C49623

CPC classification number: C07D307/935 ,  C07D305/14 ,  C07D317/72 ,  C07D493/10 ,  C07F7/1804

Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.

Abstract translation: 紫杉醇等三环和四环紫杉烷的合成