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公开(公告)号：US20240355415A1
公开(公告)日：2024-10-24
申请号：US18688211
申请日：2021-09-03
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , UNIVERSITE CÔTE D'AZUR , CHU DE NICE
发明人： Silvia BOTTINI , David PRATELLA , Marco MILANESIO , Véronique DUBOC , Véronique PAQUIS-FLUCKLINGER
IPC分类号： G16B20/10 , C12Q1/6827 , G16B40/20 , G16H10/40 , G16H50/20
CPC分类号： G16B20/10 , C12Q1/6827 , G16B40/20 , G16H10/40 , G16H50/20
摘要： Here, a suite of methods and devices is provided, allowing the implementation of a strategy for Non-Invasive Prenatal Testing (NIPT) results validation in clinical practice: a package to perform NIPT analysis, a semi-supervised approach to create synthetic sequences and to estimate confidence intervals for aneuploidies prediction and a package to test the reliability of NIPT results based on confidence intervals. These new tools were validated on 2 cohorts including confirmed ancuploidies, demonstrating sensitivity and specificity of 100%. Thus, the invention relates to a method for assessing the fetal fraction (ff) and sequencing depth (sd) in NIPT; devices for implementing the method, computer program products and computer readable mediums. This result yields the conclusion that thresholds of ff, sd and E value need to be assessed for each data analysis pipeline, chromosome and cohort. The provided devices and methods are thus of wide interest as it allows to identify these thresholds in a laboratory—specific fashion to improve NIPT performances.
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公开(公告)号：US11312863B2
公开(公告)日：2022-04-26
申请号：US14900901
申请日：2014-06-26
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) , UNIVERSITE PAUL SABATIER TOULOUSE III
摘要： A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 μm and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.
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公开(公告)号：US11045907B2
公开(公告)日：2021-06-29
申请号：US15762482
申请日：2016-09-22
申请人： Manutech-USD , Ecole Nationale d'Ingenieurs de Saint-Etienne , Ecole Centrale de Lyon , Centre National de la Recherche Scientifique (C.N.R.S.)
IPC分类号： B33Y10/00 , B33Y30/00 , B33Y40/00 , B29C64/153 , B23K26/354 , B29C64/30 , B23K26/34 , B28B1/00
摘要： A system of additive-manufacturing by laser melting of a powder bed. The system includes a first laser unit selectively emitting a first laser beam to form at least one layer of material by melting the powder bed; a second laser unit selectively emitting a second laser beam to machine at least a portion of the layer of material; and an optical unit enabling to focus the first laser beam on the powder bed to be melted and the second laser beam on the layer of material to be machined. The system is able to produce a part by successive stacking of melted then machined layers of material. A process of additive-manufacturing by laser melting of a powder bed is also contemplated.
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公开(公告)号：US10899019B2
公开(公告)日：2021-01-26
申请号：US16314959
申请日：2017-07-03
申请人： PERCIPIO ROBOTICS , SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
发明人： Stephane Regnier , Thomas Daunizeau , Dogan Sinan Haliyo , Tianming Lu , Marie Lutringer , David Heriban
摘要： A mechatronic device includes two arms extending from a base in a first direction and shaped to be handheld by an operator, the two arms having free ends forming a gripper and arranged to move closer together by rotation from a rest position to an active position, a motor housed in the base, an actuator mounted between the arms, and a means for controlling said actuator, the actuator connected to the motor so as to be driven in movement in translation in the first direction. The actuator also has a first contact surface that forms a cam with a respective second contact surface on each arm, the first contact surface remaining engaged with the second contact surface. The control means controls the movement in translation of the actuator to produce a movement in rotation of the arms that applies a chosen force of the gripper in its active position.
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公开(公告)号：US20200308652A1
公开(公告)日：2020-10-01
申请号：US16758644
申请日：2018-10-24
申请人： UNIVERSITE PARIS DESCARTES , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
IPC分类号： C12Q1/6886
摘要： This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of moesin in a sample from the subject; b) comparing the amount of moesin measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of moesin measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.
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6.发明授权公开(公告)号：US10772930B2
公开(公告)日：2020-09-15
申请号：US15937416
申请日：2018-03-27
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , UNIVERSITE DE RENNES 1 , UNIVERSITE DE BRETAGNE OCCIDENTALE
IPC分类号： C07K7/56 , A61K38/12 , C11D3/28 , C11D3/32 , C11D3/38 , C11D3/48 , C12R1/01 , A23K10/18 , A23K20/195 , A23K50/80 , A61K35/74 , A61K35/741 , C07K7/64 , A61K38/00 , A61K35/00
摘要： The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
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公开(公告)号：US10711232B2
公开(公告)日：2020-07-14
申请号：US15559947
申请日：2016-03-18
申请人： Inria Institut National De Recherche En Informatique Et En Automatique , Centre National De La Recherche Scientifique (C.N.R.S.) , Universite Pierre Et Marie Curie (Paris 6)
IPC分类号： C12M1/00
摘要： The invention relates to a bioreactor comprising a tank containing a culture medium in which a cell culture composed of algae cells is dispersed. The cell culture of algae has a concentration greater than 0.1 g/L in the culture medium, and each algal cell has a minimum absorption in a specific range of wavelengths of light. The bioreactor comprises a light source that is capable of emitting incident light in the direction of the tank, 60% of the photons of the incident light having a wavelength which is included in said specific range of wavelengths of light. The invention also relates to the use of the bioreactor for the production of biomass.
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公开(公告)号：US20190308330A1
公开(公告)日：2019-10-10
申请号：US16314959
申请日：2017-07-03
申请人： PERCIPIO ROBOTICS , SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
发明人： Stephane REGNIER , Thomas DAUNIZEAU , Dogan Sinan HALIYO , Tianming LU , Marie LUTRINGER , David HERIBAN
摘要： A mechatronic device includes two arms extending from a base in a first direction and shaped to be handheld by an operator, the two arms having free ends forming a gripper and arranged to move closer together by rotation from a rest position to an active position, a motor housed in the base, an actuator mounted between the arms, and a means for controlling said actuator, the actuator connected to the motor so as to be driven in movement in translation in the first direction. The actuator also has a first contact surface that forms a cam with a respective second contact surface on each arm, the first contact surface remaining engaged with the second contact surface. The control means controls the movement in translation of the actuator to produce a movement in rotation of the arms that applies a chosen force of the gripper in its active position.
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9.发明授权公开(公告)号：US10385466B2
公开(公告)日：2019-08-20
申请号：US14759344
申请日：2014-01-06
发明人： Mohammed Boujtita , Ugo Bussy
IPC分类号： C25B15/08 , C25B9/00 , C25B9/04 , C25B9/18 , G01N33/00 , C25B3/02 , C25B3/04 , C25B11/02 , G01N30/72 , G01N30/88
摘要： The device for electrochemically synthesizing intermediate species of a chemical entity which comprises an electrochemical oxidation cell including a first working electrode and a first counter electrode, capable, when these first electrodes are subject to an electric potential, of generating the intermediate species by oxidation of a solution introduced into the electrochemical oxidation cell and comprising the chemical entity, and an electrochemical stabilization cell including a second working electrode and a second counter electrode respectively distinct from the first working electrode and counter electrode, capable, when these second electrodes are subject to an electric potential, of achieving reduction of a solution. The stabilization cell is connected in series to the oxidation cell so as to allow continuous reduction of the intermediate species generated in the oxidation cell. Applications can be in the pharmaceutical, agri-food and environment fields.
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公开(公告)号：US10101634B2
公开(公告)日：2018-10-16
申请号：US15034553
申请日：2014-11-07
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , ECOLE NORMALE SUPERIEURE
摘要： The present invention concerns a laser scanning system (18) comprising: —a first acousto-optical deflector (30) deflecting a beam in a first direction (X) to obtain a first deflected beam and comprising a first acousto-optical crystal on which is applied an acoustic wave whose frequency varies over time according to a first law of command, and —a second acousto-optical deflector (32) deflected the first deflected beam in a second direction (Y), defining an angle comprised between 85° and 95° with the first direction, and comprising a second acousto-optical crystal on which is applied an acoustic wave whose frequency varies over time according to a second law of command, characterized in that the first law of command and the second law of command are chosen so that the average speed of the laser scanning system (18) is superior to 10 radians per second.
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