公开(公告)号：US20240310689A1

公开(公告)日：2024-09-19

申请号：US18576906

申请日：2022-07-06

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE CÔTE D'AZUR

Inventor： Christina KYROU ,  Patrice GENEVET ,  Samira KHADIR ,  Renato Juliano MARTINS

IPC: G02F1/29 ,  G02F1/133

CPC classification number: G02F1/29 ,  G02F1/133 ,  G02F2203/24

Abstract: A beam-steering device (BSD) including a dielectric substrate (DS) and a cover window (DCW), both transparent; a plurality of transparent conducting rails (VEL), extending parallel to each other between the dielectric surfaces, dividing a space between the substrates into a plurality of elongated cells (LC0-LC3); a nematic liquid crystal (LC) filling the elongated cells; and a plurality of electrical interconnections (ELI) suitable to apply an electric potential (V0-VN) to each one of the conducting rails. The pitch P of the conducting rails is smaller than an optical wavelength λ; and the height H of the conducting rails is at least equal to λ/Δn, Δn being the birefringence of the liquid crystal at the optical wavelength.

公开(公告)号：US11919854B2

公开(公告)日：2024-03-05

申请号：US17042806

申请日：2019-03-29

Applicant: Centre national de la recherche scientifique ,  CHRU de Lille ,  Universite Côte D'Azur ,  Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Université de Lille ,  YNCREA Hauts de France

Inventor： Valérie Vouret ,  Laetitia Douguet ,  Alina Ghinet ,  Germain Homerin ,  Benoît Guy Marie Rigo ,  Davy Jérémy Baudelet ,  Xavier Dezitter ,  Régis Millet ,  Christophe Furman

IPC: C07D207/16 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4439 ,  A61K39/395 ,  A61P1/00 ,  A61P35/00 ,  C07D401/12 ,  C07D409/12

CPC classification number: C07D207/16 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4439 ,  A61K39/395 ,  A61P1/00 ,  A61P35/00 ,  C07D401/12 ,  C07D409/12

Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.

公开(公告)号：US20240168167A1

公开(公告)日：2024-05-23

申请号：US18551899

申请日：2022-04-08

Applicant: UNIVERSITE CÔTE D'AZUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Patrice GENEVET ,  Renato JULIANO MARTINS ,  Samira KHADIR ,  Massimo GIUDICI

IPC: G01S17/89 ,  G01S7/48 ,  G01S7/481 ,  G01S17/48

CPC classification number: G01S17/89 ,  G01S7/4808 ,  G01S7/4814 ,  G01S7/4816 ,  G01S7/4817 ,  G01S17/48

Abstract: An optical imaging system including a transmitter unit and a receiver unit. The transmitter unit includes a light-emitting source generating at least one first optical beam at a given wavelength; a light modulator, associated with a first field of view, detects the at least one first optical beam in a first deflection direction within the first field of view to generate a first deflected beam, by applying an external control signal; and a transmissive deflecting device, associated with a second field of view and including a two-dimensional arrangement of deflecting cells, each of the deflecting cells being reachable by the first deflected beam and being associated with an elementary field of view, the transmissive deflecting device generating at least one second deflected beam from the first deflected beam using an operational deflecting cell of the plurality of deflecting cells that receives the first deflected beam.

公开(公告)号：US20240355415A1

公开(公告)日：2024-10-24

申请号：US18688211

申请日：2021-09-03

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE CÔTE D'AZUR ,  CHU DE NICE

Inventor： Silvia BOTTINI ,  David PRATELLA ,  Marco MILANESIO ,  Véronique DUBOC ,  Véronique PAQUIS-FLUCKLINGER

IPC: G16B20/10 ,  C12Q1/6827 ,  G16B40/20 ,  G16H10/40 ,  G16H50/20

CPC classification number: G16B20/10 ,  C12Q1/6827 ,  G16B40/20 ,  G16H10/40 ,  G16H50/20

Abstract: Here, a suite of methods and devices is provided, allowing the implementation of a strategy for Non-Invasive Prenatal Testing (NIPT) results validation in clinical practice: a package to perform NIPT analysis, a semi-supervised approach to create synthetic sequences and to estimate confidence intervals for aneuploidies prediction and a package to test the reliability of NIPT results based on confidence intervals. These new tools were validated on 2 cohorts including confirmed ancuploidies, demonstrating sensitivity and specificity of 100%. Thus, the invention relates to a method for assessing the fetal fraction (ff) and sequencing depth (sd) in NIPT; devices for implementing the method, computer program products and computer readable mediums. This result yields the conclusion that thresholds of ff, sd and E value need to be assessed for each data analysis pipeline, chromosome and cohort. The provided devices and methods are thus of wide interest as it allows to identify these thresholds in a laboratory—specific fashion to improve NIPT performances.

公开(公告)号：US20210017131A1

公开(公告)日：2021-01-21

申请号：US17042806

申请日：2019-03-29

Applicant: Centre national de la recherche scientifique ,  CHRU de Lille ,  Universite Côte D'Azur ,  Institut National de la Sante et da la Recherche Medicale (INSERM) ,  Université de Lille ,  YNCREA Hauts de France

Inventor： Valérie Vouret ,  Laetitia Douguet ,  Alina Ghinet ,  Germain Homerin ,  Benoît Guy Marie Rigo ,  Davy Jérémy Baudelet ,  Xavier Dezitter ,  Régis Millet ,  Christophe Furman

IPC: C07D207/16 ,  C07D401/12 ,  C07D409/12 ,  A61K39/395 ,  A61K31/4439 ,  A61K31/4025 ,  A61K31/4015 ,  A61P1/00 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the prevention and/or treatment of cancer or inflammatory diseases.

公开(公告)号：US20210380547A1

公开(公告)日：2021-12-09

申请号：US17285495

申请日：2019-10-17

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE DE PARIS ,  UNIVERSITE CÔTE D'AZUR

Inventor： RACHID BENHIDA ,  GILLES PAGES ,  MAEVA DUFIES ,  LUC DEMANGE ,  CYRIL RONCO ,  OLEKSANDR GRYTSAI

IPC: C07D277/82 ,  A61P35/00 ,  C07D235/30

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof of formulae (I) and (II), and a pharmaceutical composition comprising such compound for use for treating a cancer, particularly a cancer overexpressing CXCR1 and CXCR2 receptors, such as medulloblastoma, head and neck and kidney cancer. The invention further relates to such compounds for use for treating macular degeneration.