公开(公告)号：US06551774B1

公开(公告)日：2003-04-22

申请号：US09378535

申请日：1999-08-20

申请人： Michael D. West ,  Calvin B. Harley ,  Scott L. Weinrich ,  Catherine M. Strahl ,  Michael J. McEachern ,  Jerry Shay ,  Woodring E. Wright ,  Elizabeth H. Blackburn ,  Nam Woo Kim ,  Homayoun Vaziri

发明人： Michael D. West ,  Calvin B. Harley ,  Scott L. Weinrich ,  Catherine M. Strahl ,  Michael J. McEachern ,  Jerry Shay ,  Woodring E. Wright ,  Elizabeth H. Blackburn ,  Nam Woo Kim ,  Homayoun Vaziri

IPC分类号： C12Q168

CPC分类号： C12N15/1137 ,  A61K31/70 ,  A61K38/00 ,  C12N5/0018 ,  C12N5/163 ,  C12N9/1241 ,  C12N15/10 ,  C12N15/113 ,  C12N2501/70 ,  C12N2510/04 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q1/703 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Y207/07049 ,  C12Q2525/151 ,  C12Q2521/113

摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.

摘要翻译： 提供了用于测定端粒长度和端粒酶活性的方法和组合物，以及在增殖性疾病的治疗中增加或减少端粒酶活性的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓或逆转衰老细胞中端粒重复的丧失的手段。

公开(公告)号：US5645986A

公开(公告)日：1997-07-08

申请号：US153051

申请日：1993-11-12

申请人： Michael D. West ,  Calvin B. Harley ,  Catherine M. Strahl ,  Michael J. McEachern ,  Jerry Shay ,  Woodring E. Wright ,  Elizabeth H. Blackburn ,  Homayoun Vaziri

发明人： Michael D. West ,  Calvin B. Harley ,  Catherine M. Strahl ,  Michael J. McEachern ,  Jerry Shay ,  Woodring E. Wright ,  Elizabeth H. Blackburn ,  Homayoun Vaziri

IPC分类号： A61K38/00 ,  C12N5/00 ,  C12N5/16 ,  C12N9/12 ,  C12N15/10 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/70 ,  C12P19/34

CPC分类号： A61K31/70 ,  C12N15/10 ,  C12N15/113 ,  C12N15/1137 ,  C12N5/0018 ,  C12N5/163 ,  C12N9/1241 ,  C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q1/703 ,  C12Y207/07049 ,  A61K38/00 ,  C12N2501/70 ,  C12N2510/04 ,  C12Q2600/136

摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.

摘要翻译： 提供了用于测定端粒长度和端粒酶活性的方法和组合物，以及在增殖性疾病的治疗中增加或减少端粒酶活性的能力。 特别地，引物在使来自其它基因组序列的干扰最小化的条件下伸长，以获得端粒长度或端粒酶活性的准确测定。 此外，提供组合物用于细胞内抑制端粒酶活性，并且显示了用于减缓或逆转衰老细胞中端粒重复的丧失的手段。

公开(公告)号：US6007989A

公开(公告)日：1999-12-28

申请号：US819867

申请日：1997-03-14

申请人： Michael D. West ,  Calvin B. Harley ,  Scott L. Weinrich ,  Catherine M. Strahl ,  Michael J. McEachern ,  Jerry Shay ,  Woodring E. Wright ,  Elizabeth H. Blackburn ,  Nam Woo Kim ,  Homayoun Vaziri

发明人： Michael D. West ,  Calvin B. Harley ,  Scott L. Weinrich ,  Catherine M. Strahl ,  Michael J. McEachern ,  Jerry Shay ,  Woodring E. Wright ,  Elizabeth H. Blackburn ,  Nam Woo Kim ,  Homayoun Vaziri

IPC分类号： A61K38/00 ,  C12N5/00 ,  C12N5/16 ,  C12N9/12 ,  C12N15/10 ,  C12N15/113 ,  C12Q1/68 ,  C12Q1/70 ,  C12P19/34

CPC分类号： C12N15/1137 ,  A61K31/70 ,  C12N15/10 ,  C12N15/113 ,  C12N5/0018 ,  C12N5/163 ,  C12N9/1241 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q1/703 ,  C12Y207/07049 ,  A61K38/00 ,  C12N2501/70 ,  C12N2510/04 ,  C12Q2600/136 ,  C12Q2600/156

摘要： Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.