-
公开(公告)号：US20100168037A1
公开(公告)日：2010-07-01
申请号：US12697087
申请日：2010-01-29
申请人： Byron E. ANDERSON
发明人： Byron E. ANDERSON
CPC分类号： C07K7/06
摘要： Disclosed are D-peptides and libraries of D-peptides comprising aromatic D-amino acids. Also disclosed are methods for identifying small D-peptides comprising aromatic D-amino acids that bind to proteins of interest
摘要翻译： 公开了D肽和包含芳族D-氨基酸的D-肽的文库。 还公开了用于鉴定包含与感兴趣的蛋白质结合的芳族D-氨基酸的小D肽的方法
-
公开(公告)号：US5977076A
公开(公告)日：1999-11-02
申请号：US60393
申请日：1998-04-14
CPC分类号： A61K47/4823 , A61K38/05 , A61K47/48284
摘要： The invention provides a method of inhibiting complement in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan. The invention further provides a method of prolonging the survival of tissue transplanted into a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan. The invention also provides a method of treating an inflammatory response in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan. Finally, the invention provides a pharmaceutical composition comprising a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan--tryptophan in a pharmaceutically-acceptable vehicle.
摘要翻译： 本发明提供抑制哺乳动物补体的方法，包括向哺乳动物施用有效量的载体，其与选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸的多个二肽偶联。 本发明还提供了延长移植到哺乳动物中的组织的存活的方法，包括向哺乳动物施用有效量的载体，其与其偶联的多个二肽选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸 本发明还提供了一种治疗哺乳动物炎症反应的方法，包括向哺乳动物施用有效量的载体，其与选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸的多个二肽偶联。 最后，本发明提供一种药物组合物，其包含与药学上可接受的载体中偶联有多个选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸的二肽的载体。
-
公开(公告)号：US5932483A
公开(公告)日：1999-08-03
申请号：US628383
申请日：1996-04-05
CPC分类号： G01N33/564 , A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence:Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr 1 5 10 �SEQ ID NO 2!or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides methods of treating an inflammatory response and prolonging the survival of transplanted tissue.
摘要翻译： 本发明提供C1q的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。 本发明还提供了包含以下序列的合成肽：-Glu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr-15×10- [SEQ ID NO 2] - 或其能够结合免疫球蛋白的变体。 与C1q片段一样，多个肽可以在单体免疫球蛋白存在下选择性地结合免疫复合物或聚集的免疫球蛋白。 作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这些流体中的免疫复合物。 本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。 所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。 本发明还提供了治疗炎症反应并延长移植组织存活的方法。
-
4.发明授权Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids 失效使用针对还原性糖基化N-末端氨基酸的抗体对糖基化蛋白进行免疫测定
公开(公告)号：US5484735A
公开(公告)日：1996-01-16
申请号：US151073
申请日：1993-11-12
申请人： Lyman E. Davis , Byron E. Anderson
发明人： Lyman E. Davis , Byron E. Anderson
IPC分类号： G01N33/66 , G01N33/68 , G01N33/72 , G01N33/53 , G01N33/542
CPC分类号： G01N33/6842 , G01N33/66 , G01N33/68 , G01N33/723
摘要： An immunoassay for a protein that is non-enzymatically glycosylated on the alpha amino group of its N-terminal amino acid, the immunoassay comprising: providing a sample containing the glycosylated protein; reacting the glycosylated protein with a reducing agent so that the sugar residue on the N-terminal amino acid is reduced; contacting the reduced glycosylated protein with an antibody directed to Glc-ol-X which is prepared by immunizing an animal with an immunogen of the formula (Glc-ol-X-L).sub.n -carrier; and detecting or quantitating the reduced glycosylated protein bound to the antibody. In the formula (Glc-ol-X-L).sub.n -carrier: X is the N-terminal amino acid of the glycosylated protein, except that X cannot be lysine; L is a bond or a linker group; Glc-ol is the reduced form of the sugar attached to X on the glycosylated protein, and Glc-ol is attached to the alpha amino group of X; the carrier is an immunogenic compound other than the glycosylated protein; and n is from 1 to the number of available coupling sites on the carrier. Also, the antibody, the immunogen, and methods of making them. Finally, a kit for quantitating a protein glycosylated on its N-terminal amino acid.
摘要翻译： 对其N-末端氨基酸的α氨基上非酶促糖基化的蛋白质的免疫测定法，所述免疫测定法包括：提供含有糖基化蛋白质的样品; 使糖基化蛋白与还原剂反应，使N-末端氨基酸上的糖残基减少; 使还原的糖基化蛋白质与针对Glc-ol-X的抗体接触，其通过用式（Glc-ol-X-L）n-载体的免疫原免疫动物制备; 并检测或定量与抗体结合的还原的糖基化蛋白质。 式（Glc-ol-X-L）n-载体：X是糖基化蛋白质的N-末端氨基酸，除了X不能是赖氨酸; L是键或连接基; Glc-ol是糖基化蛋白上与X连接的糖的还原形式，Glc-ol连接到X的α氨基; 载体是除糖基化蛋白质以外的免疫原性化合物; 并且n是从1到载体上可用的偶联位点的数目。 此外，抗体，免疫原及其制备方法。 最后，用于定量在其N-末端氨基酸上糖基化的蛋白质的试剂盒。
-
公开(公告)号：US5364930A
公开(公告)日：1994-11-15
申请号：US598416
申请日：1990-10-16
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , C07K14/31 , C07K14/47 , G01N33/564 , A61K37/02 , C07K7/06 , C07K7/08
CPC分类号： A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472 , G01N33/564 , Y10S435/962 , Y10S435/975 , Y10S436/807 , Y10S436/808
摘要： The invention provides a fragment of Clq which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: ##STR1## or variants thereof capable of binding immunoglobulin. Like the Clq fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin.
摘要翻译： 本发明提供Clq的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。 本发明还提供了包含能够结合免疫球蛋白的序列的合成肽：
[SEQ ID NO 2]或其变体。 与Clq片段一样，多个肽可以在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。 作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这种流体中的免疫复合物。 本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。 所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。 -
公开(公告)号：US07655602B2
公开(公告)日：2010-02-02
申请号：US10612298
申请日：2003-07-02
申请人： Byron E. Anderson
发明人： Byron E. Anderson
IPC分类号： C40B40/10
CPC分类号： C07K7/06 , A61K38/00 , C07K1/047 , Y02A50/471
摘要： Disclosed are D-peptides and libraries of D-peptides comprising aromatic D-amino acids. Also disclosed are methods for identifying small D-peptides comprising aromatic D-amino acids that bind to proteins of interest.
摘要翻译： 公开了D肽和包含芳族D-氨基酸的D-肽的文库。 还公开了用于鉴定包含与感兴趣的蛋白质结合的芳族D-氨基酸的小D肽的方法。
-
公开(公告)号：US5759863A
公开(公告)日：1998-06-02
申请号：US441818
申请日：1995-05-16
CPC分类号： A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472 , G01N33/564 , Y10S435/962 , Y10S435/975 , Y10S436/807 , Y10S436/808
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: ##STR1## or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin.
-
8.发明授权Binding of aggregated immunoglobulin or immune complexes by serum amyloid P component 失效通过血清淀粉样蛋白P成分结合免疫球蛋白或免疫复合物
公开(公告)号：US5221628A
公开(公告)日：1993-06-22
申请号：US672526
申请日：1991-03-19
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , Y10S435/975 , Y10S436/808
摘要： A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with serum amyloid P component ("SAP"). The invention also comprises methods of using SAP to detect or quantitate immune complexes and to deplete fluids of aggregated immunoglobulin or immune complexes for diagnostic or therapeutic purposes. Also provided is a test kit comprising SAP for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids.
摘要翻译： 结合聚集的免疫球蛋白或免疫复合物的方法，包括使其与血清淀粉样蛋白P组分（“SAP”）接触。 本发明还包括使用SAP检测或定量免疫复合物并消耗聚集的免疫球蛋白或免疫复合物的流体用于诊断或治疗目的的方法。 还提供了包含用于检测或定量免疫复合物的SAP的测试试剂盒和用于从流体中除去聚集的免疫球蛋白或免疫复合物的装置。
-
公开(公告)号：US06232293B1
公开(公告)日：2001-05-15
申请号：US09398238
申请日：1999-09-20
IPC分类号： C07K506
CPC分类号： A61K38/05 , A61K47/61 , A61K47/643
摘要： The invention provides a method of inhibiting complement in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan. The invention further provides a method of prolonging the survival of tissue transplanted into a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan. The invention also provides a method of treating an inflammatory response in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan. Finally, the invention provides a pharmaceutical composition comprising a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan in a pharmaceutically-acceptable vehicle.
摘要翻译： 本发明提供抑制哺乳动物补体的方法，包括向哺乳动物施用有效量的载体，其与选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸的多个二肽偶联。 本发明还提供了延长移植到哺乳动物中的组织的存活的方法，包括向哺乳动物施用有效量的载体，其与其偶联的多个二肽选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸 本发明还提供了一种治疗哺乳动物炎症反应的方法，包括向哺乳动物施用有效量的载体，其与选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸的多个二肽偶联。 最后，本发明提供一种药物组合物，其包含与药学上可接受的载体中偶联有多个选自色氨酸 - 酪氨酸，酪氨酸 - 色氨酸和色氨酸 - 色氨酸的二肽的载体。
-
公开(公告)号：US5792669A
公开(公告)日：1998-08-11
申请号：US441819
申请日：1995-05-16
CPC分类号： A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472 , G01N33/564 , Y10S435/962 , Y10S435/975 , Y10S436/807 , Y10S436/808
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: ##STR1## or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin.
摘要翻译： 本发明提供C1q的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。 本发明还提供了包含能够结合免疫球蛋白的序列的合成肽：
[SEQ ID NO 2]或其变体。 与C1q片段一样，多个肽可以在单体免疫球蛋白存在下选择性地结合免疫复合物或聚集的免疫球蛋白。 作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这些流体中的免疫复合物。 本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。 所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.022 秒)
