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    MAGE-C2 antigenic peptides and uses therefor
    2.
    发明申请
    MAGE-C2 antigenic peptides and uses therefor 审中-公开
    MAGE-C2抗原肽及其用途

    公开(公告)号：US20090233315A1

    公开(公告)日：2009-09-17

    申请号：US12387884

    申请日：2009-05-08

    申请人： Wenbin Ma ,  Benoit Van Den Eynde ,  Thierry Boon-Falleur ,  Catherine Germeau ,  Pierre Coulie

    发明人： Wenbin Ma ,  Benoit Van Den Eynde ,  Thierry Boon-Falleur ,  Catherine Germeau ,  Pierre Coulie

    IPC分类号： G01N33/567 ,  C07K7/06

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, ∃2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.

    摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，∃2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。

    Structurally modified peptides that are resistant to peptidase degradation
    7.
    发明授权
    Structurally modified peptides that are resistant to peptidase degradation 失效
    对肽酶降解有抗性的结构修饰的肽

    公开(公告)号：US06623740B1

    公开(公告)日：2003-09-23

    申请号：US09114002

    申请日：1998-07-10

    申请人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

    发明人： Jean Edouard Gairin ,  Maha Ayyoub ,  Benoit Van Den Eynde ,  Honoré Mazarguil ,  Bernard Monsarrat

    IPC分类号： A61K3800

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  Y10S514/885

    摘要： Human melanoma cells bear antigens that are recognized by autologous CD8+ cytotoxic T-lymphocytes. The invention involves the reception of particular peptides analogues of the MZ2-E antigen by HLA molecules. Disclosed herein are peptide analogues of the tumor antigen MZ2-E that have been modified to resist peptidase degradation, and which bind HLA molecules to form a complex whose recognition by specific cytolytic T cells leads to lysis of the complex. The identification by cytolytic T cells of the peptide analogue/HLA complex may be used in diagnostics, or therapeutically.

    摘要翻译： 人黑素瘤细胞承载由自体CD8 +细胞毒性T淋巴细胞识别的抗原。 本发明涉及通过HLA分子接收MZ2-E抗原的特定肽类似物。 本文公开了经修饰以抵抗肽酶降解的肿瘤抗原MZ2-E的肽类似物，并且其结合HLA分子以形成其特异性溶细胞T细胞的识别导致复合物裂解的复合物。 肽类似物/ HLA复合物的溶细胞T细胞的鉴定可用于诊断或治疗。