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公开(公告)号：US20150008914A1
公开(公告)日：2015-01-08
申请号：US14367682
申请日：2012-01-09
申请人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
发明人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
CPC分类号： G01N27/72 , A61B1/041 , A61B5/0515 , A61B5/062 , A61B5/073 , G01R33/028 , G01R33/096 , G01R33/10
摘要： The subject matter of the invention is a detector system for detecting magnetic bodies in the human organism, which comprises at least two sensor assemblies, wherein each sensor assembly has one, two or three anisotropic magnetic resistance sensors, of which the axes of weak magnetisation point in different directions in pairs, and each sensor assembly has a spacing of 0.5 to 50 cm from the sensor assembly or the other sensor assemblies, and at least two sensor assemblies are tilted at an angle of 0 to 45° with respect to one another, and in addition a method for detecting the magnetic flux produced by a magnetic body in the human organism, and the use of the detector system according to the invention for detecting swallowed magnetic bodies and the disintegration of the same in the digestive system.
摘要翻译： 本发明的主题是用于检测人体中的磁体的检测器系统，其包括至少两个传感器组件，其中每个传感器组件具有一个，两个或三个各向异性磁阻传感器，其中弱磁化点的轴 并且每个传感器组件具有距离传感器组件或其它传感器组件0.5至50cm的间隔，并且至少两个传感器组件相对于彼此以0至45°的角度倾斜， 以及用于检测由人体中的磁体产生的磁通量的方法，以及使用根据本发明的检测器系统来检测吞咽的磁体并将其在消化系统中的分解。
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2.发明申请公开(公告)号：US20130302342A1
公开(公告)日：2013-11-14
申请号：US13988829
申请日：2010-11-26
申请人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , María del Pilar Ansuategui Panzano , Matías Javier Vara Carrera
发明人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , María del Pilar Ansuategui Panzano , Matías Javier Vara Carrera
CPC分类号： A61K47/42 , A61K38/00 , A61K38/16 , A61K38/40 , A61K47/6811 , C07K14/435 , C07K14/79
摘要： The invention refers to a human lactoferrin derived peptide for use as an antigen masking agent in the production of a pharmaceutical composition for delivery of a biological active substance in a mammalian organism, where the biological active substance is able to induce an undesired immune response by the mammalian organism, where the pharmaceutical composition comprises a supramolecular aggregate of the biological active substance and the human lactoferrin derived peptide, with the effect that after delivery of pharmaceutical composition to the mammalian organism, there is no or only a diminished induction of the undesired immune response against the biological active substance.
摘要翻译： 本发明涉及用于制备用于在哺乳动物生物体内递送生物活性物质的药物组合物中用作抗原掩蔽剂的人乳铁蛋白衍生肽，其中生物活性物质能够诱导不希望的免疫应答 哺乳动物生物体，其中药物组合物包含生物活性物质和人乳铁蛋白衍生肽的超分子聚集体，其效果是在将药物组合物递送至哺乳动物生物体后，不存在或仅减少不希望的免疫应答的诱导 针对生物活性物质。
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3.发明申请ORAL DOSAGE FORM, COMPRISING AT LEAST ONE BIOLOGICALLY ACTIVE AGENT, FORMULATION AUXILIARY SUBSTANCES AND MAGNETIZABLE PARTICLES 有权口服剂型，包含至少一种生物活性剂，配方辅助物质和可磁化颗粒公开(公告)号：US20120143039A1
公开(公告)日：2012-06-07
申请号：US13390353
申请日：2010-08-30
申请人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
发明人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
CPC分类号： A61K9/2072 , A61K9/0009 , A61K9/0053 , A61K9/2095 , A61K9/2813 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K9/4883 , A61K9/5094
摘要： The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
摘要翻译： 本发明涉及口服剂型，其包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒，其中所述剂型具有至少两相组合物，其中所述相可以在口服给药后溶于体内，因为它们 制剂和可磁化颗粒结合在制剂辅助物质中并以磁化状态存在，其中磁化颗粒存在于剂型的至少两个相中并产生磁场，其中这些相在体内不同时间溶解在体内 并且其中使用检测系统获取相对于身体中的时间，位置和运动的磁场强度，并且可以使用基于计算机的评估系统进行评估。
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公开(公告)号：US09724422B2
公开(公告)日：2017-08-08
申请号：US13988829
申请日：2010-11-26
申请人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , Maria del Pilar Ansuategui Panzano , Matias Javier Vara Carrera
发明人： Benedikt Hartwig , Juan Tome Alcalde , Norbert Windhab , Maria del Pilar Ansuategui Panzano , Matias Javier Vara Carrera
IPC分类号： C07K14/00 , C07K14/435 , C07K14/79 , A61K38/16 , A61K38/40 , A61K47/42 , A61K47/48 , A61K38/00
CPC分类号： A61K47/42 , A61K38/00 , A61K38/16 , A61K38/40 , A61K47/6811 , C07K14/435 , C07K14/79
摘要： The invention refers to a human lactoferrin derived peptide for use as an antigen masking agent in the production of a pharmaceutical composition for delivery of a biological active substance in a mammalian organism, where the biological active substance is able to induce an undesired immune response by the mammalian organism, where the pharmaceutical composition comprises a supramolecular aggregate of the biological active substance and the human lactoferrin derived peptide, with the effect that after delivery of pharmaceutical composition to the mammalian organism, there is no or only a diminished induction of the undesired immune response against the biological active substance.
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公开(公告)号：US09696279B2
公开(公告)日：2017-07-04
申请号：US14367682
申请日：2012-01-09
申请人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
发明人： Benedikt Hartwig , Peter Niepoth , Steffen Junginger , Hans-Joachim Stiller , Norbert Windhab , Gerhard Geipel
CPC分类号： G01N27/72 , A61B1/041 , A61B5/0515 , A61B5/062 , A61B5/073 , G01R33/028 , G01R33/096 , G01R33/10
摘要： The subject matter of the invention is a detector system for detecting magnetic bodies in the human organism, which comprises at least two sensor assemblies, wherein each sensor assembly has one, two or three anisotropic magnetic resistance sensors, of which the axes of weak magnetization point in different directions in pairs, and each sensor assembly has a spacing of 0.5 to 50 cm from the sensor assembly or the other sensor assemblies, and at least two sensor assemblies are tilted at an angle of 0 to 45° with respect to one another, and in addition a method for detecting the magnetic flux produced by a magnetic body in the human organism, and the use of the detector system according to the invention for detecting swallowed magnetic bodies and the disintegration of the same in the digestive system.
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6.发明申请PERSONALIZED DETECTION SYSTEM FOR DETECTING MAGNETIC OBJECTS IN THE HUMAN ORGANISM 审中-公开用于检测人体内磁性物体的个性化检测系统公开(公告)号：US20160135759A1
公开(公告)日：2016-05-19
申请号：US14899400
申请日：2014-06-06
CPC分类号： A61B5/7475 , A61B5/05 , A61B5/4205 , A61B5/6804 , A61B2562/0223 , A61B2562/04 , A61J3/007 , G01R33/096 , G01V3/081
摘要： The invention relates to a device with a sensor arrangement, which is able to detect magnetic or magnetized oral administration forms after oral take-up, moreover tracks the dissolution thereof via the reduction or disappearance of the magnetic field of the oral administration form, and with a log function, which records a subjective evaluation on the part of the human wearer of the sensor arrangement during or after the oral take-up.
摘要翻译： 本发明涉及具有传感器装置的装置，其能够在口服吸收后检测磁性或磁化的口服给药形式，而且通过口服给药形式的磁场的减少或消失来跟踪其溶出，并且与 记录功能，其记录在口服吸收期间或之后传感器装置的人的佩戴者的主观评价。
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7.发明授权Oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles 有权口服剂型，包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒公开(公告)号：US09050256B2
公开(公告)日：2015-06-09
申请号：US13390353
申请日：2010-08-30
申请人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
发明人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
CPC分类号： A61K9/2072 , A61K9/0009 , A61K9/0053 , A61K9/2095 , A61K9/2813 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K9/4883 , A61K9/5094
摘要： The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
摘要翻译： 本发明涉及口服剂型，其包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒，其中所述剂型具有至少两相组合物，其中所述相可以在口服给药后溶于体内，因为它们 制剂和可磁化颗粒结合在制剂辅助物质中并以磁化状态存在，其中磁化颗粒存在于剂型的至少两个相中并产生磁场，其中这些相在体内不同时间溶解在体内 并且其中使用检测系统获取相对于身体中的时间，位置和运动的磁场强度，并且可以使用基于计算机的评估系统进行评估。
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8.发明申请CURABLE COMPOSITION BASED ON EPOXY RESINS AND HETERO-POLY-CYCLIC POLYAMINES 审中-公开基于环氧树脂和异环聚氨酯的可固化组合物公开(公告)号：US20110281117A1
公开(公告)日：2011-11-17
申请号：US13142665
申请日：2009-12-03
申请人： Martina Ortelt , Dirk Fuchsmann , Benedikt Hartwig
发明人： Martina Ortelt , Dirk Fuchsmann , Benedikt Hartwig
IPC分类号： C08L63/00 , B32B15/092 , B29C70/30 , B29C45/00 , B65H81/00 , C09D163/00 , B32B27/38
CPC分类号： C08G59/5046 , C08K5/17 , C08L63/00 , C09D163/00 , C09J163/00 , Y10T428/31511 , Y10T428/31529
摘要： The invention relates to curable compositions substantially comprising A) at least one epoxy resin, and B) at least one curing agent comprising a hetero-poly-cyclic ring system comprising at least two amino groups.
摘要翻译： 本发明涉及可固化组合物，其基本上包含A）至少一种环氧树脂，和B）至少一种包含至少两个氨基的杂多环系统的固化剂。
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