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公开(公告)号：US11591409B2
公开(公告)日：2023-02-28
申请号：US16498223
申请日：2018-03-28
发明人： Jiawang Liu , Nanmeng Song , Yaping Yang , Mengxie Jin
摘要： Provided are an anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and a preparation thereof. In particular, provided are a highly stable heterodimeric anti-PD-L1/anti-PD-1 bispecific antibody with characteristics of a natural IgG and without mismatches heavy chain-light chain, and a preparation thereof. The bispecific antibody can bind to both target molecules and is more effective in treating a complex disease.
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公开(公告)号：US11117967B2
公开(公告)日：2021-09-14
申请号：US16332880
申请日：2017-09-08
发明人： Yaping Yang , Jiawang Liu , Nanmeng Song , Hongjuan Zhang , Mengxie Jin
IPC分类号： A61K39/00 , C07K16/28 , A61K47/68 , A61P35/00 , A61K49/00 , A61K49/16 , A61K49/22 , A61K51/10
摘要： An antibody specifically binding to PD-1 and a functional fragment thereof. The antibody or functional fragment thereof includes a PD-1 chimeric antibody and a functional fragment thereof, and a PD-1 humanized antibody and a functional fragment thereof.
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3.发明申请公开(公告)号：US20200299412A1
公开(公告)日：2020-09-24
申请号：US16498223
申请日：2018-03-28
发明人： Jiawang Liu , Nanmeng Song , Yaping Yang , Mengxie Jin
摘要： Provided are an anti-PD-L1/anti-PD-1 natural antibody structure-like heterodimeric bispecific antibody and a preparation thereof. In particular, provided are a highly stable heterodimeric anti-PD-L1/anti-PD-1 bispecific antibody with characteristics of a natural IgG and without mismatches heavy chain-light chain, and a preparation thereof. The bispecific antibody can bind to both target molecules and is more effective in treating a complex disease.
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4.发明授权公开(公告)号：US11072651B2
公开(公告)日：2021-07-27
申请号：US16332900
申请日：2017-09-08
发明人： Nanmeng Song , Jiawang Liu , Yaping Yang , Yang Yang , Dongge Yang , Hongjuan Zhang , Mengxie Jin
IPC分类号： A61K39/395 , C07K16/24 , A61K47/68 , A61K49/00 , A61K49/16 , A61K49/22 , A61K51/10 , A61P19/08 , A61P43/00 , A61P27/02 , A61P11/00 , A61P11/06 , A61P17/06 , A61P37/08 , A61P19/02 , A61P1/12 , A61P17/14 , A61P17/00 , A61P25/00 , A61P31/04 , A61P1/04 , A61P37/06 , A61P7/06 , A61P29/00 , A61P13/12 , A61P9/02 , A61P37/02 , A61P1/00 , A61K39/00
摘要： An antibody specifically binding to IL-17A or a functional fragment thereof. The antibody or functional fragment thereof includes an IL-17A chimeric antibody and a functional fragment thereof, and an IL-17A humanized antibody and a functional fragment thereof.
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5.发明申请公开(公告)号：US20200172529A1
公开(公告)日：2020-06-04
申请号：US16639646
申请日：2018-08-17
发明人： Tao ZHAO , Dong WEI , Min LI , Maeng Sup KIM , Chul Woong CHUNG
IPC分类号： C07D413/12 , C07D413/14 , C07D471/04 , A61P35/02 , A61P37/06
摘要： Provided are a pyrimidinyl amino compound having protein kinase inhibitor activity, and a pharmaceutical composition containing said compound; also provided are a use and application of said compound. What is provided is selected from a group consisting of the compound represented by formula (I), a stereoisomer thereof, a tautomer thereof, a pharmacologically acceptable salt thereof, a solvate thereof, and a prodrug thereof. The described compound has good inhibitory activity against the JAK family of kinases and the SYK family of kinases, and therefore may serve as a JAK inhibitor and SYK inhibitor, and is effective in use for the prevention or treatment of diseases related to the JAK and SYK families of kinases.
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公开(公告)号：US20190256588A1
公开(公告)日：2019-08-22
申请号：US16332900
申请日：2017-09-08
发明人： Nanmeng Song , Jiawang Liu , Yaping Yang , Yang Yang , Dongge Yang , Hongjuan Zhang , Mengxie Jin
摘要： An antibody specifically binding to IL-17A or a functional fragment thereof. The antibody or functional fragment thereof includes an IL-17A chimeric antibody and a functional fragment thereof, and an IL-17A humanized antibody and a functional fragment thereof.
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