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公开(公告)号：US20240207075A1
公开(公告)日：2024-06-27
申请号：US17802448
申请日：2020-05-27
发明人： Dong Bian , Wenjiao Lin
CPC分类号： A61F2/82 , A61L31/022 , A61L31/088 , A61L31/10 , A61L31/16 , A61F2250/0031 , A61F2250/0036 , A61F2250/0054 , A61F2250/0067
摘要： Disclosed is an absorbable iron-based instrument (10). The absorbable iron-based instrument includes an iron-based matrix (100), a zinc-containing protective layer (200), a corrosion-promoting layer (300) and a drug controlled-release layer (400); the iron-based matrix (100) is provided with an outer wall (110), an inner wall (120) and a side wall (130); the zinc-containing protective layer (200) covers at least the outer wall (110) and the inner wall (120) of the iron-based matrix (100); the corrosion-promoting layer (300) fully covers the zinc-containing protective layer (200); the drug controlled-release layer (400) partially covers at least the corrosion-promoting layer (300); the corrosion-promoting layer (300) and the drug controlled-release layer (400) each contain degradable polymers; the weight-average molecular weight of the degradable polymers in the corrosion-promoting layer (300) is greater than the weight-average molecular weight of the degradable polymers in the drug controlled-release layer (400); and the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the inner wall (120) to a portion of the corrosion-promoting layer (300) that is located at the inner wall (120) is greater than the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the outer wall (110) to a portion of the corrosion-promoting layer (300) that is located at the outer wall (110). The corrosion behavior of the absorbable iron-based instrument (10) meets the requirements of clinical use, and the occurrence of adverse histological reactions is rare or avoided.
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公开(公告)号：US11819591B2
公开(公告)日：2023-11-21
申请号：US15775137
申请日：2016-06-27
发明人： Wenjiao Lin , Deyuan Zhang
CPC分类号： A61L31/148 , A61L17/10 , A61L31/022 , A61L31/06 , A61L31/10 , A61L31/128 , A61L27/042 , A61L31/128 , C08L67/04 , A61L31/128 , C08L73/02 , A61L31/128 , C08L77/04 , A61L31/06 , C08L67/04 , A61L31/06 , C08L73/02 , A61L31/06 , C08L77/04 , A61L31/10 , C08L77/04 , A61L31/10 , C08L73/02 , A61L31/10 , C08L67/04
摘要： An iron-based alloy absorbable and implantable medical device for internal fixation. A substrate includes an iron-based alloy and degradable polymer. The mass ratio of the iron-based alloy to the degradable polymer is between 1:4 and 4:1. The weight-average molecular weight of the degradable polymer is between 150000 to 3000000, and the polydispersity index thereof is between 1 and 6. The device further includes antioxidants. The iron-based alloy is used as a load-bearing framework or reinforcement phase of the device. By adjusting the mass ratio of the iron-based alloy to the degradable polymer and the combination mode thereof, the corrosion rate of the iron-based alloy in the late period of the implantation is accelerated, and the quantity of corrosion products poorly soluble in the iron-based alloy is reduced. Adding antioxidants to the device further reduces the quantity of the corrosion products poorly soluble in the iron-based alloy.
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公开(公告)号：US20220062015A1
公开(公告)日：2022-03-03
申请号：US17418409
申请日：2019-10-31
发明人： Liping CHEN , Wenjiao LIN , Wanqian ZHANG
摘要： A drug eluting device and a preparation method thereof are disclosed. The drug eluting device includes a substrate and a drug coating arranged on the substrate. The substrate has an outer wall, side walls, and an inner wall, the drug coating contains active drug and a drug carrier, the active drug is dispersed in the drug carrier, the drug coating covers the outer wall, the side walls, and the inner wall of the substrate, and the content of the active drug on both the outer wall and the side walls are greater than the content of the active drug on the inner wall; or, the active drug is only distributed on the outer wall and the side walls, and the inner wall does not contain the active drug. The drug eluting device is less prone to coating peeling off from the substrate.
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公开(公告)号：US20210402068A1
公开(公告)日：2021-12-30
申请号：US17288184
申请日：2019-10-31
发明人： Wenjiao LIN , Dong BIAN
摘要： An absorbable implantable device, including an iron-based substrate, and a zinc-containing protective layer and a corrosion promoting layer provided on the iron-based substrate. The iron-based substrate has an outer wall and an inner wall. The zinc-containing protective layer covers the outer wall and the inner wall of the iron-based substrate. The corrosion promoting layer covers the zinc-containing protective layer. The thickness ratio of the zinc-containing protective layer located on the outer wall to the corrosion promoting layer located on the outer wall is less than the thickness ratio of the zinc-containing protective layer located on the inner wall to the corrosion promoting layer located on the inner wall. The absorbable implantable device has a low risk of thrombosis and can meet the requirements of early support and later rapid corrosion.
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5.发明授权公开(公告)号：US11969368B2
公开(公告)日：2024-04-30
申请号：US17859563
申请日：2022-07-07
发明人： Deyuan Zhang , Xianmiao Chen , Wenjiao Lin , Xiangdong Liu
IPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , C21D8/10 , C21D9/08 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26 , B21C1/00 , B21C1/24
CPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , A61L31/022 , C21D8/105 , C21D9/08 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26 , A61F2240/001 , B21C1/00 , B21C1/003 , B21C1/24
摘要： A lumen stent preform is provided using a plasma nitriding technology, a preparation method thereof, a method for preparing a lumen stent by using the preform, and a lumen stent obtained according to the method. The preform is manufactured by using pure iron or an iron alloy containing no strong nitrogen compound, has a hardness of 160-250HV0.05/10, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. Alternatively, the preform is an iron alloy containing a strong nitrogen compound, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. The lumen stem preform meets the requirements of a conventional stent for radial strength and plasticity, so that plasma nitriding is applicable to commercial preparation of a lumen stent.
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公开(公告)号：US20230142931A1
公开(公告)日：2023-05-11
申请号：US17915430
申请日：2021-04-07
发明人： Deyuan Zhang , Haiping Qi , Wenjiao Lin
CPC分类号： A61L31/022 , C08L67/04 , A61L31/16 , A61L31/10
摘要： The present invention relates to a zinc-containing medical device, including a zinc-containing matrix and a polylactic acid coating arranged on the zinc-containing matrix. The polylactic acid coating has a thickness of x μm; and when x and the weight-average molecular weight Mn (kDa) of polylactic acid satisfied the following formula:
(
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b
+
b
2
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4
a
c
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/
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a
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2
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x
≤
(
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b
+
b
2
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4
a
c
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/
2
a
+
2
,
the corrosion rate of zinc in the matrix is relatively small, sufficient mechanical properties can be maintained within the repair period, and the biological risk is relatively low. When the polylactic acid is poly-racemic lactic acid, a=0.0336 ln(Mn)−0.1449, b=−0.472 ln(Mn)+2.1524, and c=1.1604 ln(Mn)−5.7128; and when the polylactic acid is poly-L-lactic acid, a=−0.006 ln(Mn)+0.03441, b=0.0648 ln(Mn)−0.3662, and c=−0.162 ln(Mn)+0.7847.-
公开(公告)号：US20220142795A1
公开(公告)日：2022-05-12
申请号：US17580928
申请日：2022-01-21
发明人： Wenjiao LIN , Wenchao FU
摘要： An absorbable stent includes an absorbable matrix. The matrix includes a number of wave-shaped rings connected by connection units and arranged in an axial direction. The wave-shaped ring includes a number of waves arranged in a circumferential direction. A peak, a valley and a support connecting the peak and the valley form the wave. Two adjacent wave-shaped rings and the connection unit form a closed side supporting unit. The matrix has a volume of 4 μm to 40 μm per unit blood vessel area. The absorbable stent has sufficient radial supporting strength of no less than 55 kPa for clinical applications. Moreover, the volume of the matrix per unit blood vessel area is less than volumes of existing stents. When the absorbable stent and existing stents are made of the same material, the absorbable stent has a shorter degradation and absorption cycle.
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公开(公告)号：US20210393858A1
公开(公告)日：2021-12-23
申请号：US17288685
申请日：2019-10-14
发明人： Wenchao FU , Wenjiao LIN , Li QIN
摘要： An implantable device including a metal substrate; that contains particles having a size of 1 μm or more; if the wall thickness of the metal substrate is greater than or equal to 0.04 mm and less than or equal to 0.12 mm, the largest particle size is less than or equal to 15 μm and the average content of the particles is less than or equal to 40 ppm; if the wall thickness of the metal substrate is greater than 0.12 mm and less than or equal to 0.2 mm, the largest particle size is less than or equal to 20 μm and the average content of the particles is less than or equal to 100 ppm; The size of the particles and the average content of the particles are reasonably controlled according to the wall thickness of the metal substrate, improving the plastic deformation capability of the implantable device.
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公开(公告)号：US20230256142A1
公开(公告)日：2023-08-17
申请号：US18304485
申请日：2023-04-21
发明人： Deyuan ZHANG , Haiping QI , Wenjiao LIN , Gui ZHANG , Li QIN
CPC分类号： A61L31/022 , A61L31/14 , A61L31/10 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2400/18
摘要： An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.
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公开(公告)号：US11690738B2
公开(公告)日：2023-07-04
申请号：US16768286
申请日：2018-10-17
发明人： Li Qin , Wenjiao Lin
CPC分类号： A61F2/82 , A61F2002/91583 , A61F2240/001 , A61F2250/0098
摘要： A stent and a preparation method therefor. The stent includes a stent substrate. The stent substrate is provided with at least one radiopaque structure thereon. Each radiopaque structure includes at least one radiopaque unit. A radiopaque material is inlaid in each radiopaque unit, and a ratio of the volume of the radiopaque material to the volume of the radiopaque unit ranges from 1.1 to 1.4. By the stent and the preparation method therefor, the interference fit between the radiopaque material and the radiopaque unit can be better implemented, so that the radiopaque material and the radiopaque unit have strong bonding force therebetween, and the problem of embolism caused by the drop of a radiopaque material is avoided.
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