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公开(公告)号：US08883509B2
公开(公告)日：2014-11-11
申请号：US12167459
申请日：2008-07-03
申请人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
发明人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译： 描述了实现多个基板支持的生物样品的独立且同时处理的装置和方法。 在一个实施例中，布置成小弧的衬底保持器可以在处理位置和访问位置之间独立地移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板被传送到保持在衬底保持器中的衬底。 所公开的装置和方法特别适合于实施生物样品的精益加工。
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公开(公告)号：US20050250211A1
公开(公告)日：2005-11-10
申请号：US11181625
申请日：2005-07-13
申请人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
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公开(公告)号：US20050074890A1
公开(公告)日：2005-04-07
申请号：US10848775
申请日：2004-05-18
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。
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公开(公告)号：US07618807B2
公开(公告)日：2009-11-17
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。
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公开(公告)号：US20090017491A1
公开(公告)日：2009-01-15
申请号：US12167459
申请日：2008-07-03
申请人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
发明人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译： 描述了实现多个基板支持的生物样品的独立且同时处理的装置和方法。 在一个实施例中，布置成小弧的衬底保持器可以在处理位置和访问位置之间独立地移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板被传送到保持在衬底保持器中的衬底。 所公开的装置和方法特别适合于实施生物样品的精益加工。
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公开(公告)号：US07468161B2
公开(公告)日：2008-12-23
申请号：US11116676
申请日：2005-04-27
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译： 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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公开(公告)号：US20080020450A1
公开(公告)日：2008-01-24
申请号：US11863834
申请日：2007-09-28
申请人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
发明人： Charles Lemme , William Richards , David Bryant , Catherine Wolf , Andrew Ghusson , Austin Ashby , Wayne Showalter , Anthony Hartman , Brian Kram
IPC分类号： C12M1/42
摘要： The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue staining by applying an electric field to a tissue sample in the presence of an electrolyte and biomolecular conjugates of interest suspended in the electrolyte. Typical staining times are reduced to seconds as opposed to 30-120 minutes common in the prior art. The invention is also directed to devices for performing the method.
摘要翻译： 本发明引入了将生物分子缀合物加速进入组织，从而引起组织染色目的的目标的完全不同的方式。 本发明提供了相对于用于染色组织的现有技术扩散过程的一个数量级的改进。 本发明包括通过在存在电解质和悬浮在电解质中的目标生物分子共轭物的情况下向组织样品施加电场的组织染色方法。 典型的染色时间减少到几秒，而不是现有技术中常见的30-120分钟。 本发明还涉及用于执行该方法的装置。
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公开(公告)号：US20050186114A1
公开(公告)日：2005-08-25
申请号：US11116676
申请日：2005-04-27
申请人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译： 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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公开(公告)号：US08663991B2
公开(公告)日：2014-03-04
申请号：US11181625
申请日：2005-07-13
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译： 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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