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公开(公告)号：US08663991B2
公开(公告)日：2014-03-04
申请号：US11181625
申请日：2005-07-13
Applicant: Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
Inventor： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC: G01N35/00
CPC classification number: G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
Abstract: An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
Abstract translation: 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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2.发明授权Removal of embedding media from biological samples and cell conditioning on automated staining instruments 有权从生物样品和细胞调节中去除嵌入介质在自动染色仪器上公开(公告)号：US07410753B2
公开(公告)日：2008-08-12
申请号：US10394996
申请日：2003-03-21
Applicant: Keri Hopkins , Alexis Pusch , Catherine Wolf , Anthony Hartman , James Pettay , Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
Inventor： Keri Hopkins , Alexis Pusch , Catherine Wolf , Anthony Hartman , James Pettay , Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
CPC classification number: G01N1/36 , G01N1/30 , Y10T436/21 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
Abstract: The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents comprise components optimized to facilitate removal or etching of the embedding media from the biological sample. The present invention also provides reagents for use in an automated environment for cell conditioning biological samples wherein the cells are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The reagents comprise components optimized to facilitate molecular access to cells and cell constituents within the biological sample.
Abstract translation: 本发明提供用于在自动化环境中用于通过在组织化学或细胞化学程序中暴露待染色的生物样品而不依赖有机溶剂来去除或蚀刻包埋介质的试剂。 试剂包括优化以有助于从生物样品中去除或蚀刻嵌入介质的组分。 本发明还提供用于细胞调节生物样品的自动化环境中的试剂，其中细胞易于被试剂分子进入用于组织化学和细胞化学染色程序。 试剂包含优化的促进分子进入生物样品中的细胞和细胞组分的组分。
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3.发明授权公开(公告)号：US06855552B2
公开(公告)日：2005-02-15
申请号：US09800689
申请日：2001-03-07
Applicant: Penny Towne , Joseph Utermohlen , Chad Wilkinson , Paula Rodgers , Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
Inventor： Penny Towne , Joseph Utermohlen , Chad Wilkinson , Paula Rodgers , Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
CPC classification number: G01N35/00029 , C12Q1/6841 , G01N1/30 , G01N1/36 , G01N35/1002 , G01N2035/00049 , G01N2035/00356 , G01N2035/0441 , Y10T436/10 , Y10T436/107497 , Y10T436/108331 , C12Q2527/125
Abstract: The present invention provides reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The components of the reagents are optimized to facilitate molecular access to cells and cell constituents within the biological sample. The present invention also provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The components of the reagents are optimized to facilitate removal or etching of the embedding media from the biological sample.
Abstract translation: 本发明提供用于生物样品的细胞调节的自动化环境中的试剂，其中细胞或组织易于被试剂分子进入用于组织化学和细胞化学染色程序。 优化试剂的组分以促进分子进入生物样品内的细胞和细胞组分。 本发明还提供了用于在自动化环境中用于通过在组织化学或细胞化学方法中暴露待染色的生物样品而不依赖有机溶剂来去除或蚀刻包埋介质的试剂。 试剂的组分被优化以便于从生物样品中去除或蚀刻嵌入介质。
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公开(公告)号：US06582962B1
公开(公告)日：2003-06-24
申请号：US09690296
申请日：2000-10-17
Applicant: William Richards , Charles D. Lemme , Kimberly Christensen , Ethel R. Macrea
Inventor： William Richards , Charles D. Lemme , Kimberly Christensen , Ethel R. Macrea
IPC: G01N3500
CPC classification number: G01N35/1002 , G01N1/30 , G01N1/31 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/2575
Abstract: Apparatus and methods for automatically staining or treating multiple tissue samples mounted on microscope slides are provided. Individualized slide temperature control is accomplished by the heating system according to the present invention that has thermal platforms radially mounted to the carousel for heating the slides and sensing the temperature of each. The heating system also permits automated de-waxing if necessary.
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公开(公告)号：US07468161B2
公开(公告)日：2008-12-23
申请号：US11116676
申请日：2005-04-27
Applicant: Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
Inventor： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC classification number: G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
Abstract: An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
Abstract translation: 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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Patent Agency Ranking
公开(公告)号：US07067325B2
公开(公告)日：2006-06-27
申请号：US10320219
申请日：2002-12-16
Applicant: Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
Inventor： Kimberly Christensen , Ethel Macrea , Noemi Sebastiao
IPC: G01N33/567
CPC classification number: G01N1/36 , G01N1/30 , Y10T436/11 , Y10T436/21 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
Abstract: The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents comprise components optimized to facilitate removal or etching of the embedding media from the biological sample. The present invention also provides reagents for use in an automated environment for cell conditioning biological samples wherein the cells are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The reagents comprise components optimized to facilitate molecular access to cells and cell constituents within the biological sample.
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公开(公告)号：US20050186114A1
公开(公告)日：2005-08-25
申请号：US11116676
申请日：2005-04-27
Applicant: Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
Inventor： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC classification number: G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
Abstract: An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
Abstract translation: 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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8.发明授权Hybridization buffers using low molecular weight dextran sulfate and methods for their use 失效使用低分子量硫酸葡聚糖的杂交缓冲液及其使用方法公开(公告)号：US06656685B2
公开(公告)日：2003-12-02
申请号：US09772123
申请日：2001-01-29
Applicant: Joseph Utermohlen , Catherine Wolf , Kimberly Christensen
Inventor： Joseph Utermohlen , Catherine Wolf , Kimberly Christensen
IPC: C12Q168
CPC classification number: C12Q1/6832 , C12Q2527/125
Abstract: The invention is directed to an improvement in automated tissue staining system having evaporation inhibitor liquid covering the polynucleotide hybridization buffer-covered tissue on a slide, wherein the improvement comprises a polynucleotide hybridization buffer for in situ hybridization comprising a low molecular weight dextran sulfate having a molecular weight range from about 8,000 to about 16,000.
Abstract translation: 本发明涉及自动化组织染色系统的改进，其具有覆盖载玻片上的多核苷酸杂交缓冲液覆盖的组织的蒸发抑制剂液体，其中改进包括用于原位杂交的多核苷酸杂交缓冲液，其包含具有分子 重量范围从约8,000至约16,000。
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9.发明授权Removal of embedding media from biological samples and cell conditioning on automated staining instruments 有权从生物样品和细胞调节中去除嵌入介质在自动染色仪器上公开(公告)号：US06544798B1
公开(公告)日：2003-04-08
申请号：US09853200
申请日：2001-05-11
Applicant: Kimberly Christensen , Ethel R. Macrea , Noemi Sebastiao , Glen Ward
Inventor： Kimberly Christensen , Ethel R. Macrea , Noemi Sebastiao , Glen Ward
IPC: G01N118
CPC classification number: G01N1/36 , Y10T436/107497 , Y10T436/25125 , Y10T436/25375
Abstract: The present invention provides reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The reagents include components optimized to facilitate molecular access to cells and cell constituents within the biological sample. The present invention also provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents include components optimized to facilitate removal or etching of the embedding media from the biological sample.
Abstract translation: 本发明提供用于生物样品的细胞调节的自动化环境中的试剂，其中细胞或组织易于被试剂分子进入用于组织化学和细胞化学染色程序。 试剂包括经过优化以促进分子进入生物样品中的细胞和细胞组分的组分。 本发明还提供了用于在自动化环境中用于通过在组织化学或细胞化学方法中暴露待染色的生物样品而不依赖有机溶剂来去除或蚀刻包埋介质的试剂。 试剂包括优化以促进从生物样品中去除或蚀刻嵌入介质的组分。
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公开(公告)号：US20050250211A1
公开(公告)日：2005-11-10
申请号：US11181625
申请日：2005-07-13
Applicant: Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
Inventor： Kurt Reinhardt , Charles Lemme , Glen Ward , William Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC classification number: G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
Abstract: An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
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