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    Methods for enhancing antigen-specific immune response using antibodies that bind OX-40
    2.
    发明授权
    Methods for enhancing antigen-specific immune response using antibodies that bind OX-40 有权
    使用结合OX-40的抗体增强抗原特异性免疫应答的方法

    公开(公告)号：US07504101B2

    公开(公告)日：2009-03-17

    申请号：US09946832

    申请日：2001-09-04

    申请人： Andrew D. Weinberg

    发明人： Andrew D. Weinberg

    IPC分类号： A61K39/395 ,  C07K16/00

    CPC分类号： A61K38/177 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/55516 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30

    摘要： Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified antibody that specifically binds the OX-40 receptor and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the antibody that specifically binds the OX-40 receptor is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.

    摘要翻译： 公开了通过使T细胞表面上的OX-40受体接合来增强哺乳动物对抗原的免疫应答的组合物和方法，包括向哺乳动物施用包含特异性结合OX-40受体的纯化抗体的组合物 和药学上可接受的载体，其中向哺乳动物施用所述组合物，使得特异性结合OX-40受体的抗体在由抗原引发T细胞期间或不久之后呈递给哺乳动物的T细胞。 这样的组合物和方法可用于免疫和癌症治疗。

    Method for enhancing an antigen specific immune response with OX-40L
    6.
    发明授权
    Method for enhancing an antigen specific immune response with OX-40L 有权
    用OX-40L增强抗原特异性免疫反应的方法

    公开(公告)号：US06312700B1

    公开(公告)日：2001-11-06

    申请号：US09255363

    申请日：1999-02-23

    申请人： Andrew D. Weinberg

    发明人： Andrew D. Weinberg

    IPC分类号： A61K3900

    CPC分类号： A61K38/177 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/55516 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30

    摘要： Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.

    摘要翻译： 公开了通过使T细胞表面上的OX-40受体结合来增强哺乳动物对抗原的免疫应答的组合物和方法，包括向哺乳动物施用包含纯化的OX-40受体结合剂和药学上 其中所述组合物被施用于哺乳动物，使得OX-40受体结合剂在由抗原引发T细胞期间或不久之后呈递给哺乳动物的T细胞。 这样的组合物和方法可用于免疫和癌症治疗。

    Methods for using OX-40 ligand to enhance an antigen specific immune response
    7.
    发明授权
    Methods for using OX-40 ligand to enhance an antigen specific immune response 有权
    使用OX-40配体增强抗原特异性免疫应答的方法

    公开(公告)号：US07622444B2

    公开(公告)日：2009-11-24

    申请号：US11529956

    申请日：2006-09-29

    申请人： Andrew D. Weinberg

    发明人： Andrew D. Weinberg

    IPC分类号： A61K38/17 ,  C07K14/435

    CPC分类号： A61K38/177 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/55516 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30

    摘要： Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein the composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.

    摘要翻译： 公开了通过使T细胞表面上的OX-40受体结合来增强哺乳动物对抗原的免疫应答的组合物和方法，包括向哺乳动物施用包含纯化的OX-40受体结合剂和药学上 可接受的载体，其中向哺乳动物施用组合物，使得OX-40受体结合剂在由抗原引发T细胞期间或不久之后呈递给哺乳动物的T细胞。 这样的组合物和方法可用于免疫和癌症治疗。

    T-cell antigens, and their use in diagnosis and treatment of T-cell mediated conditions
    8.
    发明授权
    T-cell antigens, and their use in diagnosis and treatment of T-cell mediated conditions 失效
    T细胞抗原及其在诊断和治疗T细胞介导的病症中的应用

    公开(公告)号：US06566082B1

    公开(公告)日：2003-05-20

    申请号：US08469633

    申请日：1995-06-06

    申请人： Andrew D. Weinberg ,  Arthur A. Vandenbark

    发明人： Andrew D. Weinberg ,  Arthur A. Vandenbark

    IPC分类号： G01N3353

    CPC分类号： A61K49/0058 ,  A61K38/00 ,  A61K47/6849 ,  A61K51/1039 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2319/00 ,  Y10S530/866 ,  Y10S530/867 ,  Y10S530/868

    摘要： The OX-40 antigen is characterized and claimed together with variants and derivatives thereof. Also described are binding agents for the antigen and the use of these in diagnosis and therapy. Examples of such use include a method for the selective depletion of activated CD4+ T-cells in vivo by using immunotoxins comprising an OX-40 antibody conjugated to a toxic molecule (such as Ricin-A chain). The administration of these specific immunotoxins is used therapeutically to deplete autoimmune reactive CD4+ T-cells which have been implicated in diseases including Multiple Sclerosis, Rheumatoid Arthritis, Sarcoidosis, and Autoimmune Uveitis as well as inflammatory bowel disease and graft-versus-host disease. This type of therapy is also beneficial for eradicating CD4+ T-cell lymphomas and alloreactive CD4+ T-cells involved with a transplantation reaction. The use of the human form of the OX-40 antibody will also help in the early diagnosis of all the diseases mentioned above.

    摘要翻译： OX-40抗原与其变体和衍生物一起被表征和要求。 还描述了用于抗原的结合剂和它们在诊断和治疗中的用途。 这种用途的实例包括通过使用包含与毒性分子缀合的OX-40抗体（例如蓖麻毒素A链）的免疫毒素在体内选择性消耗活化的CD4 + T细胞的方法。 这些特异性免疫毒素的施用在治疗上用于消除已涉及包括多发性硬化症，类风湿关节炎，结节病和自身免疫性葡萄膜炎以及炎性肠病和移植物抗宿主病在内的疾病的自身免疫反应性CD4 + T细胞。 这种治疗方法也有利于根除与移植反应相关的CD4 + T细胞淋巴瘤和同种异体反应性CD4 + T细胞。 OX-40抗体的人体形态的使用也有助于早期诊断上述所有疾病。