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公开(公告)号：US20110207730A1
公开(公告)日：2011-08-25
申请号：US12970532
申请日：2010-12-16
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/5375 , C07D207/325 , A61K31/40 , C07D413/02 , C07C211/38 , A61K31/135 , C07D241/06 , A61K31/4965 , C07D491/113 , A61K31/438 , C07D277/24 , A61K31/426 , A61P9/00 , C12N5/071
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US06399618B1
公开(公告)日：2002-06-04
申请号：US09111684
申请日：1998-07-08
IPC分类号： A61K31495
CPC分类号： A61K31/495
摘要： The present invention discloses that a substituted acetic acid derivatives containing a N-alkylpiperazino moiety are useful as pro-libido agents for males and females, and may be used for the treatment of sexual dysfunction including impotence and to enhance sexual performance.
摘要翻译： 本发明公开了含有N-烷基哌嗪基部分的取代的乙酸衍生物可用作男性和女性的性欲药物，并且可用于治疗包括阳of的性功能障碍并增强性能。
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公开(公告)号：US07875611B2
公开(公告)日：2011-01-25
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/40 , C07D265/30 , C07D207/04
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US20100029639A1
公开(公告)日：2010-02-04
申请号：US12424450
申请日：2009-04-15
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/32 , A61K31/5375 , A61K31/40 , C07D207/08 , C07D409/08 , A61P9/00
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US07057053B2
公开(公告)日：2006-06-06
申请号：US11018428
申请日：2004-12-21
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： C07D207/12 , A61K31/40
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D207/12 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07345087B2
公开(公告)日：2008-03-18
申请号：US11394388
申请日：2006-03-30
申请人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Gregory N. Beatch , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/40 , C07D207/12
CPC分类号： C07D207/12 , C07D207/08 , C07D207/10 , C07D207/20 , C07D207/24 , C07D277/04 , C07D295/096 , C07D333/56 , C07D405/12 , C07D487/12 , C07D491/10 , C07D491/113
摘要： Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
摘要翻译： 公开了氨基环己基醚化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了化合物和组合物的用途，包括治疗心律失常。
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公开(公告)号：US07101877B2
公开(公告)日：2006-09-05
申请号：US10674684
申请日：2003-09-29
申请人： Allen I Bain , Gregory N Beatch , Cindy J Longley , Bertrand M C Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
发明人： Allen I Bain , Gregory N Beatch , Cindy J Longley , Bertrand M C Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L Yong , Jeff Jiqun Zhu , Alexander B Zolotoy
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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8.发明授权Complementary compositions to reduce blood glucose levels and treat diabetes 失效用于降低血糖水平和治疗糖尿病的补充组合物公开(公告)号：US07687082B2
公开(公告)日：2010-03-30
申请号：US11400777
申请日：2006-04-07
CPC分类号： A61K31/194 , A61K31/191 , A61K31/28 , A61K31/385 , A61K31/555 , A61K31/715 , A61K31/736 , A61K33/06 , A61K33/14 , A61K36/258 , A61K36/54 , A61K36/888 , A61K45/06 , A61K2300/00
摘要： Serial administration of two complementary compositions effectively reduces and stabilizes glucose levels in the blood of mammals, specifically in pre-diabetic patients and patients with type 2 diabetes mellitus (T2DM). The first composition (Comp1) comprises (−)-hydroxycitric acid ((−)-HCA), magnesium salt (Mg) and konjac mannan (KM). The second composition (Comp2) comprises chromium picolinate (CrPic), magnesium salt (Mg) and alpha-lipoic acid (α-LA). The second composition may include one or more of Comp1, cinnamon extract (CE) and American ginseng (AG).
摘要翻译： 两种互补组合物的连续给药有效地降低和稳定哺乳动物血液中的葡萄糖水平，特别是在糖尿病前期患者和2型糖尿病患者（T2DM）中。 第一组合物（Comp1）包含（ - ） - 羟基柠檬酸（（ - ） - HCA），镁盐（Mg）和魔芋甘露聚糖（KM）。 第二组合物（Comp2）包含吡啶甲酸铬（CrPic），镁盐（Mg）和α-硫辛酸（α-LA）。 第二组合物可以包括一种或多种Comp1，肉桂提取物（CE）和美国人参（AG）。
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公开(公告)号：US07534790B2
公开(公告)日：2009-05-19
申请号：US11944282
申请日：2007-11-21
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/426 , A61K31/403 , A61K31/4015 , A61K31/40 , C07D295/033 , C07D413/02 , C07D295/027 , C07D277/04 , C07D209/96 , C07D207/12
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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10.发明申请COMPOUNDS TO TREAT AMYLOIDOSIS AND PREVENT DEATH OF BETA-CELLS IN TYPE 2 DIABETES MELLITUS 审中-公开治疗类2型糖尿病的β细胞的淀粉样变性和预防死亡的化合物公开(公告)号：US20080255091A1
公开(公告)日：2008-10-16
申请号：US12143691
申请日：2008-06-20
IPC分类号： A61K31/55 , A61K31/165 , A61K31/421 , A61K31/18 , A61K31/4164
CPC分类号： C07C233/65 , A61K31/166 , A61K31/385 , A61K31/4412 , C07D213/68 , C07D213/74 , C07D213/81 , C07D223/22 , C07D233/70 , C07D235/26 , C07D241/44 , C07D263/38 , C07D263/58 , C07D471/04
摘要： The invention discloses aromatic amides and sulfonates to treat or prevent type 2 diabetes mellitus (T2DM), the pathological consequences of T2DM, to inhibit amyloidosis or to prevent death of β-cells of the pancreas.
摘要翻译： 本发明公开了用于治疗或预防2型糖尿病（T2DM）的二恶烷和磺酸盐，T2DM的病理后果，抑制淀粉样变性或预防胰腺β细胞死亡。
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