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101 条记录 (耗时 0.036 秒)

    Contrast agents
    3.
    发明授权
    Contrast agents 失效
    对比剂

    公开(公告)号：US08273325B2

    公开(公告)日：2012-09-25

    申请号：US12519183

    申请日：2007-12-19

    申请人： Helge Tolleshaug ,  Alan Cuthbertson ,  Hege Karlsen

    发明人： Helge Tolleshaug ,  Alan Cuthbertson ,  Hege Karlsen

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/0054 ,  A61K49/0032 ,  A61K49/0056

    摘要： The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.

    摘要翻译： 本发明提供含有这些化合物的新化合物和药物组合物，其中化合物对蛋白聚糖具有亲和力。 所述化合物包含与带正电荷部分连接的基于氨基酸的核心单元。 所述化合物还包含在体内成像中可检测的至少一个成像部分，使得该化合物可用作蛋白聚糖成像的诊断造影剂，例如硫酸乙酰肝素蛋白聚糖。

    Peptide-based compounds
    6.
    发明申请
    Peptide-based compounds 失效
    基于肽的化合物

    公开(公告)号：US20100256330A1

    公开(公告)日：2010-10-07

    申请号：US12814621

    申请日：2010-06-14

    申请人： Alan CUTHBERTSON

    发明人： Alan CUTHBERTSON

    IPC分类号： C07K7/64

    CPC分类号： C07K14/70546 ,  A61K51/082 ,  C07K7/06

    摘要： This invention relates to new peptide-based compounds and their use in therapeutically effective treatments as well as for diagnostic imaging techniques. More specifically the invention relates to the use of such peptide-based compounds used as targeting vectors that bind to receptors associated with angiogenesis, in particular the αvβ3 integrin receptor. Such contrast agents may thus be used for diagnosis of for example malignant diseases, heart diseases, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma. Moreover such compounds may also be used in therapeutic treatment of these diseases.

    摘要翻译： 本发明涉及新的基于肽的化合物及其在治疗有效治疗以及诊断成像技术中的用途。 更具体地，本发明涉及用作与血管生成相关的受体结合的靶向载体的这种基于肽的化合物的用途，特别是αv＆bgr 3整合素受体。 因此，这样的造影剂可用于诊断例如恶性疾病，心脏病，炎症相关疾病，类风湿性关节炎和卡波西氏肉瘤。 此外，这些化合物也可用于治疗这些疾病。

    Pharmaceutical compounds
    7.
    发明授权
    Pharmaceutical compounds 失效
    药物化合物

    公开(公告)号：US07785566B2

    公开(公告)日：2010-08-31

    申请号：US10559886

    申请日：2004-11-05

    申请人： Alan Cuthbertson ,  Bard Indrevoll ,  Morten Eriksen

    发明人： Alan Cuthbertson ,  Bard Indrevoll ,  Morten Eriksen

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K51/08 ,  A61K38/085 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/088 ,  C07K7/14

    摘要： The invention comprises pharmaceuticals of formula (I) Z-(L)n-V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n denotes 0 or 1. The pharmaceuticals are active as therapeutic agents for the treatment of heart failure, cardiac arrhythmias and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis and are also useful as diagnostic agents for the diagnosis of heart failure and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis.

    摘要翻译： 本发明包括式（I）Z-（L）nV的药物，其中V表示肽，L表示任选的接头，Z表示任选可携带成像部分M的基团，n表示0或1.药物为 作为治疗心力衰竭的治疗剂，心律失常和疾病的纤维化是COPD，肝纤维化和动脉粥样硬化的突出特征，也可用作诊断心力衰竭的诊断剂，并且纤维化是突出的如COPD， 肝纤维化和动脉粥样硬化。

    METHOD FOR FABRICATING CONDUCTING PLATES FOR A HIGH-Q MIM CAPACITOR
    8.
    发明申请
    METHOD FOR FABRICATING CONDUCTING PLATES FOR A HIGH-Q MIM CAPACITOR 有权
    用于制造高Q MIM电容器的导电板的方法

    公开(公告)号：US20100019349A1

    公开(公告)日：2010-01-28

    申请号：US12569750

    申请日：2009-09-29

    申请人： Isaiah O. Oladeji ,  Alan Cuthbertson

    发明人： Isaiah O. Oladeji ,  Alan Cuthbertson

    IPC分类号： H01L29/92

    CPC分类号： H01L27/0805 ,  H01L21/76838 ,  H01L28/75

    摘要： A method of forming one or more capacitors on or in a substrate and a capacitor structure resulting therefrom is disclosed. The method includes forming a trench in the substrate, lining the trench with a first copper-barrier layer, and substantially filling the trench with a first copper layer. The first copper layer is substantially chemically isolated from the substrate by the first copper-barrier layer. A second copper-barrier layer is formed over the first copper layer and a first dielectric layer is formed over the second copper-barrier layer. The dielectric layer is substantially chemically isolated from the first copper layer by the second copper-barrier layer. A third copper-barrier layer is formed over the dielectric layer and a second copper layer is formed over the third copper-barrier layer. The second copper layer is formed in a non-damascene process.

    摘要翻译： 公开了一种在衬底上或衬底中形成一个或多个电容器的方法以及由此产生的电容器结构。 该方法包括在衬底中形成沟槽，用第一铜阻挡层衬套沟槽，并用第一铜层基本上填充沟槽。 第一铜层通过第一铜阻挡层与衬底基本上化学隔离。 在第一铜层上形成第二铜阻挡层，在第二铜阻挡层上形成第一电介质层。 电介质层通过第二铜阻挡层与第一铜层基本上化学隔离。 在电介质层上形成第三铜阻挡层，在第三铜阻挡层上形成第二铜层。 第二铜层以非镶嵌工艺形成。

    Liposomes
    10.
    发明申请
    Liposomes 审中-公开
    脂质体

    公开(公告)号：US20080206151A1

    公开(公告)日：2008-08-28

    申请号：US11912206

    申请日：2006-04-25

    申请人： Alan Cuthbertson

    发明人： Alan Cuthbertson

    IPC分类号： A61K49/18 ,  A61K9/127 ,  C07F9/06

    CPC分类号： A61K49/0466 ,  A61K49/1812 ,  A61K51/1234

    摘要： The present invention relates to a process for the manufacture of targeting liposomes comprising vector compounds conjugated to the hydrophilic part of modified phospholipids. The present invention provides the modified phospholipids and liposomes containing said modified phospholipids.

    摘要翻译： 本发明涉及制备靶向脂质体的方法，其包含与改性磷脂的亲水部分缀合的载体化合物。 本发明提供了含有所述修饰的磷脂的改性磷脂和脂质体。