发明申请
- 专利标题： ALDH: A COMPOUND FOR CANCER STEM CELL IMAGING
- 专利标题（中）： ALDH：用于癌症干细胞成像的化合物
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申请号： US13510398申请日： 2010-12-22
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公开(公告)号： US20120251449A1公开(公告)日： 2012-10-04
- 发明人: Vijaya Raj Kuniyil Kulangara , Alan Cuthbertson , Peter Iveson , Chitralekha Rangaswamy , Veena Rao , Rajiv Bhalla
- 申请人： Vijaya Raj Kuniyil Kulangara , Alan Cuthbertson , Peter Iveson , Chitralekha Rangaswamy , Veena Rao , Rajiv Bhalla
- 优先权： IN2685/DEL/2009 20091222
- 国际申请： PCT/US10/61697 WO 20101222
- 主分类号： A61K51/04
- IPC分类号： A61K51/04 ; C07C47/55 ; A61P35/00 ; C07C223/06 ; C07C223/04 ; C07C47/353
摘要：
The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates.
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