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公开(公告)号：US20130149249A1
公开(公告)日：2013-06-13
申请号：US13817826
申请日：2011-08-22
IPC分类号： C07F13/00 , A61K51/04 , C07D241/24
CPC分类号： C07F13/005 , A61K51/0459 , A61K51/0478 , A61K51/0497 , C07D241/24
摘要： The present invention provides novel in vivo imaging agents useful for detecting the presence of mycobacteria using in vivo imaging methods. Also provided by the present invention is a precursor compound useful in the synthesis of the in vivo imaging agents of the invention, and a method to obtain the in vivo imaging agent of the invention using said precursor compound. Methods of in vivo imaging and diagnosis in which the in vivo imaging agent of the invention finds use are also provided.
摘要翻译： 本发明提供了可用于使用体内成像方法检测分枝杆菌存在的新型体内显像剂。 本发明还提供了可用于合成本发明的体内显像剂的前体化合物，以及使用所述前体化合物获得本发明的体内显像剂的方法。 还提供了本发明的体内显像剂使用的体内成像和诊断方法。
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公开(公告)号：US20120251449A1
公开(公告)日：2012-10-04
申请号：US13510398
申请日：2010-12-22
申请人： Vijaya Raj Kuniyil Kulangara , Alan Cuthbertson , Peter Iveson , Chitralekha Rangaswamy , Veena Rao , Rajiv Bhalla
发明人： Vijaya Raj Kuniyil Kulangara , Alan Cuthbertson , Peter Iveson , Chitralekha Rangaswamy , Veena Rao , Rajiv Bhalla
IPC分类号： A61K51/04 , C07C47/55 , A61P35/00 , C07C223/06 , C07C223/04 , C07C47/353
CPC分类号： A61K31/136 , A61K51/04
摘要： The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates.
摘要翻译： 本发明要求氟 - 碘基醛作为ALDH底物用作诊断显像剂或作为治疗剂。 醛直接和间接连接到芳环或直链环上。 通过酸产物的形成或醛底物的消耗来监测ALDH活性。
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公开(公告)号：US20100076199A1
公开(公告)日：2010-03-25
申请号：US12561481
申请日：2009-09-17
IPC分类号： C07D213/69
CPC分类号： C07D213/69 , C07D213/79
摘要： The present invention relates to methods for the preparation of pyridone carboxylic acids for use as intermediates in the preparation of various synthetic organic compounds. The pyridone carboxylic acids can for example be used as intermediates in the production of potent antitumor agents, antifungal agents, antiviral agents, psychotherapeutic agents or contrast imaging agents for MRI.
摘要翻译： 本发明涉及制备用于制备各种合成有机化合物的中间体的吡啶酮羧酸的方法。 吡啶酮羧酸可以例如用作生产有效的抗肿瘤剂，抗真菌剂，抗病毒剂，心理治疗剂或用于MRI的造影剂的中间体。
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公开(公告)号：US20130078185A1
公开(公告)日：2013-03-28
申请号：US13700187
申请日：2011-05-31
IPC分类号： A61K51/04 , C07B59/00 , C07F7/22 , C07D498/04
CPC分类号： A61K51/0453 , C07B59/002 , C07D498/04 , C07F7/2208
摘要： The present invention provides novel compounds useful in the treatment and diagnosis of mycobacterial infections. Compounds of the present invention have enhanced biological properties as compared to the related known compounds. The present invention also provides a precursor compound useful in the synthesis of certain compounds of the invention, and a method to obtain these compounds using said precursor compound. Methods of treatment and diagnosis in which the compounds of the invention fmd use are also provided.
摘要翻译： 本发明提供了可用于治疗和诊断分枝杆菌感染的新化合物。 与相关已知化合物相比，本发明的化合物具有增强的生物学性质。 本发明还提供了可用于合成本发明某些化合物的前体化合物，以及使用所述前体化合物获得这些化合物的方法。 还提供了使用本发明化合物的治疗和诊断方法。
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公开(公告)号：US20110286922A1
公开(公告)日：2011-11-24
申请号：US13124703
申请日：2009-10-20
IPC分类号： A61K51/04 , C07C223/02 , C07C47/55 , C07C235/84 , C07C47/575 , C07C311/39 , C07D217/26 , C07D215/48 , C07D215/42 , C07D215/36 , C07F5/02 , C07D209/12 , C07D209/42 , A61P35/00 , A61K49/00
CPC分类号： A61K51/04 , A61K51/0446 , A61K51/0455 , A61K51/0478 , A61K51/0482
摘要： The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer.
摘要翻译： 本发明涉及靶向酶醛脱氢酶（ALDH）并适用于体内成像肿瘤和治疗癌症的体内成像和放射治疗方法和试剂。
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