公开(公告)号：US07964160B2

公开(公告)日：2011-06-21

申请号：US11459073

申请日：2006-07-21

申请人： Adi Zuppiger ,  Pascal Stäheli ,  Joas Leemann ,  Carsten Hase

发明人： Adi Zuppiger ,  Pascal Stäheli ,  Joas Leemann ,  Carsten Hase

IPC分类号： B01L3/00

CPC分类号： G01N1/14 ,  B01L3/021 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2400/0487 ,  G01N35/1016 ,  G01N2035/1025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/2575

摘要： The invention relates to a pipetting apparatus (1) having a pipette tip (2) for aspirating and dispensing liquid samples; a pump (4) for generating negative pressure or positive pressure in the pipette tip (2) that is connected to the pipette tip (2) by means of a pump conduit (3); a fluid chamber (5) defined by the pipette tip (2) and/or the pump conduit (3); a measurement probe (6) functionally connected to the fluid chamber (5) for measuring the physical parameters resulting in this fluid chamber (5) during pipetting; and a device control system (7) with a processor (8), in which an activated computer program product enables the control system (7) of the pipetting apparatus (1) to individually accept or reject pipetted liquid samples on the basis of the physical parameters measured. The pipetting apparatus (1) in accordance with the invention is characterized in that it comprises a data storage device (9) for storing an actual measured curve (41) measured during pipetting and a simulated curve (42) for such a pipetting procedure and also a computer program product that in an activated state enables the processor (8) of this pipetting apparatus (1) to generate this simulated curve (42) and approximate it to the actual measured curve (41) iteratively to create an iterative curve (43) and then matching the pipetting and/or the corresponding pipetted liquid samples to one of a plurality of decision-making criteria on the basis of sections of the measured curve (44) in the actual measured curve (41) that deviate from defined threshold values (45) in relation to the corresponding sections of the curve (46) of the iterative curve (43). A corresponding computer program product and method are included within the scope of the invention.

摘要翻译： 本发明涉及一种具有用于抽吸和分配液体样品的移液管吸头（2）的移液装置（1） 用于通过泵管道（3）连接到移液管吸头（2）的移液管吸头（2）中产生负压或正压的泵（4）; 由移液管吸头（2）和/或泵管道（3）限定的流体室（5）; 功能上连接到流体室（5）的测量探头（6），用于在移液期间测量导致该流体室（5）的物理参数; 以及具有处理器（8）的设备控制系统（7），其中激活的计算机程序产品使得移液装置（1）的控制系统（7）能够基于物理上的单独接收或拒绝移液液体样品 参数测量。 根据本发明的移液装置（1）的特征在于其包括用于存储在移液期间测量的实际测量曲线（41）的数据存储装置（9）和用于这种移液程序的模拟曲线（42） 处于激活状态的计算机程序产品使得该移液装置（1）的处理器（8）能够产生该模拟曲线（42）并将其近似于实际测量曲线（41）以迭代地产生迭代曲线（43） 然后基于实际测量曲线（41）中偏离定义的阈值（41）的测量曲线（44）的部分，将移液和/或相应的移液液样品与多个决策标准中的一个进行匹配（ 45）相对于迭代曲线（43）的曲线（46）的相应部分。 在本发明的范围内包括相应的计算机程序产品和方法。

公开(公告)号：US20090117010A1

公开(公告)日：2009-05-07

申请号：US12354322

申请日：2009-01-15

申请人： Torleif Ove Bjorson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

发明人： Torleif Ove Bjorson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

IPC分类号： B01L3/02

CPC分类号： G01N35/1009 ,  G01F23/185 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A pipetting apparatus has a fluidic space to which a pressure transducer with a pressure sensor is attached with a gas filled space. The fluidic space is defined by a pipette tip, a first tubing that connects the pipette tip to a pump, and an active part of the pump. The pipetting apparatus further has an impulse generating mechanism that is in operative contact with a column of system liquid inside the fluidic space. The impulse generating mechanism induces a vertical movement in the system liquid column, which results in a pressure variation in the gas filled space that is pneumatically connected with the fluidic space. This pressure variation, as recorded with the pressure transducer and as processed by a first data processing unit during utilization of this pipetting apparatus, is taken as an indicator for the detection of penetration or of quitting of a surface of a liquid, with an orifice of the pipette tip, of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid contained in the fluidic space of this pipetting apparatus.

摘要翻译： 移液装置具有流体空间，具有压力传感器的压力传感器与气体填充空间相连。 流体空间由移液管尖端，将移液管尖端连接到泵的第一管和泵的有效部分限定。 移液装置还具有脉冲发生机构，其与流体空间内的系统液体柱可操作地接触。 脉冲产生机构在系统液柱中引起垂直运动，这导致与流体空间气动连接的气体填充空间中的压力变化。 该压力变化记录在压力传感器中并且在利用该移液装置期间被第一数据处理单元处理时被用作用于检测液体的表面的渗透或退出的指示器，其中孔口 移液管尖端，其中液体的量将被吸入和分配。 该压力变化也被用作检测包含在该移液装置的流体空间中的系统液体中是否存在气泡的指标。

公开(公告)号：US07479391B2

公开(公告)日：2009-01-20

申请号：US11009247

申请日：2004-12-10

申请人： Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

发明人： Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

IPC分类号： B01L3/02

CPC分类号： G01N35/1009 ,  G01F23/185 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A pipetting apparatus (1) comprises a fluidic space (7), to which a pressure transducer (11) with a pressure sensor (12) is attached with a gas filled space (15). The fluidic space (7) is defined by a pipette tip (2), a first tubing (5) that connects the pipette tip (2) to a pump (4), and an active part (6) of the pump (4). The pipetting apparatus (1) according to the present invention is characterized in that the pipetting apparatus (1) further comprises an impulse generating means (16, 18, 19) that is in operative contact with a column (10) of system liquid (8) inside the fluidic space (7). The impulse generating means (16, 18, 19) is designed to induce a vertical movement in this system liquid column (10), which results in a pressure variation in the gas filled space (15) that is pneumatically connected with the fluidic space (7). This pressure variation—as recorded with the pressure transducer (11) and as processed by a first data processing unit (13) during utilization of this pipetting apparatus—is taken as an indicator for the detection of penetration or of quitting of a surface (17) of a liquid, with an orifice (3) of the pipette tip (2), of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid (8) contained in the fluidic space (7) of this pipetting apparatus.

摘要翻译： 移液装置（1）包括流体空间（7），具有压力传感器（12）的压力传感器（11）与气体填充空间（15）连接在该流体空间上。 流体空间（7）由移液管吸头（2），将移液管吸头（2）连接到泵（4）的第一管（5）和泵（4）的有源部分（6） 。 根据本发明的移液装置（1）的特征在于，移液装置（1）还包括与系统液体（8）的柱（10）有效接触的脉冲发生装置（16,18,19） ）在流体空间（7）内。 脉冲发生装置（16,18,19）被设计成在该系统液柱（10）中引起垂直运动，这导致与流体空间气动连接的气体填充空间（15）中的压力变化（ 7）。 该压力变化（如压力传感器11记录的）并且在利用该移液装置期间由第一数据处理单元（13）处理）被作为用于检测表面的穿透或退出的指示器（17 ），其具有移液器吸头（2）的孔口（3），其中液体的量将被吸入和分配。 该压力变化也被用作检测包含在该移液装置的流体空间（7）中的系统液体（8）中是否存在气泡的指示器。

公开(公告)号：US20070025882A1

公开(公告)日：2007-02-01

申请号：US11459073

申请日：2006-07-21

申请人： Adi ZUPPIGER ,  Pascal Staheli ,  Joas Leemann ,  Carsten Hase

发明人： Adi ZUPPIGER ,  Pascal Staheli ,  Joas Leemann ,  Carsten Hase

IPC分类号： B01L3/02

CPC分类号： G01N1/14 ,  B01L3/021 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2400/0487 ,  G01N35/1016 ,  G01N2035/1025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/2575

摘要： The invention relates to a pipetting apparatus (1) having a pipette tip (2) for aspirating and dispensing liquid samples; a pump (4) for generating negative pressure or positive pressure in the pipette tip (2) that is connected to the pipette tip (2) by means of a pump conduit (3); a fluid chamber (5) defined by the pipette tip (2) and/or the pump conduit (3); a measurement probe (6) functionally connected to the fluid chamber (5) for measuring the physical parameters resulting in this fluid chamber (5) during pipetting; and a device control system (7) with a processor (8), in which an activated computer program product enables the control system (7) of the pipetting apparatus (1) to individually accept or reject pipetted liquid samples on the basis of the physical parameters measured. The pipetting apparatus (1) in accordance with the invention is characterized in that it comprises a data storage device (9) for storing an actual measured curve (41) measured during pipetting and a simulated curve (42) for such a pipetting procedure and also a computer program product that in an activated state enables the processor (8) of this pipetting apparatus (1) to generate this simulated curve (42) and approximate it to the actual measured curve (41) iteratively to create an iterative curve (43) and then matching the pipetting and/or the corresponding pipetted liquid samples to one of a plurality of decision-making criteria on the basis of sections of the measured curve (44) in the actual measured curve (41) that deviate from defined threshold values (45) in relation to the corresponding sections of the curve (46) of the iterative curve (43). A corresponding computer program product and method are included within the scope of the invention.

公开(公告)号：US20070020763A1

公开(公告)日：2007-01-25

申请号：US11488473

申请日：2006-07-18

申请人： Nikolaus Ingenhoven ,  Robert Liebhard ,  Adi Zuppiger ,  Werner Halg

发明人： Nikolaus Ingenhoven ,  Robert Liebhard ,  Adi Zuppiger ,  Werner Halg

IPC分类号： G01N35/00

CPC分类号： G01N1/14 ,  B01L3/021 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2400/0487 ,  G01N35/1016 ,  G01N2035/1025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/2575

摘要： The present invention relates to a method for classifying a liquid (1) in a known pipetting system for this liquid (1), the method being characterized in that the changes of a selected, measurable, and physically founded virtual parameter are detected as a data set typical for this liquid (1); this typical data set of the selected virtual parameter is compared to corresponding data sets of known liquids, and the liquid (1) is classified on the basis of this comparison. An especially preferred method and a device for classifying a liquid (1) relate to a device which comprises a fluid chamber (2), to which a measuring chamber (3) is connected, whose internal pressure is monitored using a pressure transducer (4). At least a first part (5) of this fluid chamber (2) may be brought into fluid connection with a sample (6) of this liquid (1). A preferred device according to the present invention is characterized in that it comprises a pulse unit (17), using which pressure changes may be generated in an essentially coherent fluid column (7) situated in the fluid chamber (2). These pressure changes cause corresponding pressure changes in the measuring chamber (3), which is pneumatically connected to the fluid column (7), which are recorded by the pressure transducer (4) and converted into measuring signals. The device additionally comprises a computer or microprocessor (8), using which these measuring signals of the pressure transducer (4) may be processed and reproduced as a pressure curve (9), so that the course of this pressure curve (9) may be compared to the course of known pressure curves (9′,9″) and the liquid (1) may be classified on the basis of this comparison.

摘要翻译： 本发明涉及一种用于对该液体（1）的已知吸移系统中的液体（1）进行分类的方法，其特征在于，将所选择的，可测量的和物理上建立的虚拟参数的变化作为数据被检测 为这种液体（1）设定典型; 将所选虚拟参数的典型数据集与已知液体的相应数据集进行比较，并且基于该比较对液体（1）进行分类。 用于分类液体（1）的特别优选的方法和装置涉及一种包括流体室（2）的装置，其中连接有测量室（3），其内部压力使用压力传感器（4）监测， 。 该流体室（2）的至少第一部分（5）可以与该液体（1）的样品（6）流体连接。 根据本发明的优选装置的特征在于，其包括脉冲单元（17），利用其可以在位于流体室（2）中的基本上相干的流体柱（7）中产生压力变化。 这些压力变化导致测量室（3）中相应的压力变化，气压连接到由压力传感器（4）记录的流体柱（7）并被转换为测量信号。 该装置还包括计算机或微处理器（8），利用这些计算机或微处理器（8）可以将压力传感器（4）的这些测量信号作为压力曲线（9）进行处理和再现，使得该压力曲线（9）的过程可以是 与已知压力曲线（9'，9“）的过程相比，液体（1）可以基于该比较进行分类。

公开(公告)号：US08287806B2

公开(公告)日：2012-10-16

申请号：US12354322

申请日：2009-01-15

申请人： Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

发明人： Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

IPC分类号： B01L3/02

CPC分类号： G01N35/1009 ,  G01F23/185 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A pipetting apparatus has a fluidic space to which a pressure transducer with a pressure sensor is attached with a gas filled space. The fluidic space is defined by a pipette tip, a first tubing that connects the pipette tip to a pump, and an active part of the pump. The pipetting apparatus further has an impulse generating mechanism that is in operative contact with a column of system liquid inside the fluidic space. The impulse generating mechanism induces a vertical movement in the system liquid column, which results in a pressure variation in the gas filled space that is pneumatically connected with the fluidic space. This pressure variation, as recorded with the pressure transducer and as processed by a first data processing unit during utilization of this pipetting apparatus, is taken as an indicator for the detection of penetration or of quitting of a surface of a liquid, with an orifice of the pipette tip, of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid contained in the fluidic space of this pipetting apparatus.

摘要翻译： 移液装置具有流体空间，具有压力传感器的压力传感器与气体填充空间相连。 流体空间由移液管尖端，将移液管尖端连接到泵的第一管和泵的有效部分限定。 移液装置还具有脉冲发生机构，其与流体空间内的系统液体柱可操作地接触。 脉冲产生机构在系统液柱中引起垂直运动，这导致与流体空间气动连接的气体填充空间中的压力变化。 该压力变化记录在压力传感器中并且在利用该移液装置期间由第一数据处理单元处理，被作为用于检测液体的表面的渗透或退出的指示器，其中孔口 移液管尖端，其中液体的量将被吸入和分配。 该压力变化也被用作检测包含在该移液装置的流体空间中的系统液体中是否存在气泡的指标。

公开(公告)号：US20120242354A1

公开(公告)日：2012-09-27

申请号：US13504379

申请日：2010-12-22

申请人： Nicolas Cors ,  Markus Schoni ,  Markus Wiggli ,  Adi Zuppiger

发明人： Nicolas Cors ,  Markus Schoni ,  Markus Wiggli ,  Adi Zuppiger

IPC分类号： G01N27/22 ,  G01R27/26

CPC分类号： G01F23/268 ,  G01F23/266 ,  G01N35/1011 ,  G01N2035/1025

摘要： A device for detecting a phase boundary in a liquid tank a sensor that can be advanced in the direction of the phase boundary in the liquid tank. A circuit processes an output signal of the sensor to detect a change in capacitance and has a first channel with a first filter module to filter out a first signal having a short pulse width from the output signal and a second channel having a second filter module to filter out a second signal having a greater pulse width from the output signal. A controller module with comparator module determines whether the first signal reaches a first threshold value and a processing module determines whether the second signal meets predefined second signal criteria.

摘要翻译： 一种用于检测液罐中相位边界的装置，该传感器可以在液罐中的相边界方向前进。 A电路处理传感器的输出信号以检测电容的变化，并且具有第一通道与第一滤波器模块以从输出信号中滤出具有短脉冲宽度的第一信号，以及具有第二滤波器模块的第二通道 从输出信号中滤出具有较大脉冲宽度的第二信号。 具有比较器模块的控制器模块确定第一信号是否达到第一阈值，并且处理模块确定第二信号是否满足预定义的第二信号准则。

公开(公告)号：US09335200B2

公开(公告)日：2016-05-10

申请号：US13504379

申请日：2010-12-22

申请人： Nicolas Cors ,  Markus Schoni ,  Markus Wiggli ,  Adi Zuppiger

发明人： Nicolas Cors ,  Markus Schoni ,  Markus Wiggli ,  Adi Zuppiger

IPC分类号： G01F23/26 ,  G01N35/10

CPC分类号： G01F23/268 ,  G01F23/266 ,  G01N35/1011 ,  G01N2035/1025

摘要： A device for detecting a phase boundary in a liquid tank a sensor that can be advanced in the direction of the phase boundary in the liquid tank. A circuit processes an output signal of the sensor to detect a change in capacitance and has a first channel with a first filter module to filter out a first signal having a short pulse width from the output signal and a second channel having a second filter module to filter out a second signal having a greater pulse width from the output signal. A controller module with comparator module determines whether the first signal reaches a first threshold value and a processing module determines whether the second signal meets predefined second signal criteria.

摘要翻译： 一种用于检测液罐中相位边界的装置，该传感器可以在液罐中的相边界方向前进。 A电路处理传感器的输出信号以检测电容的变化，并且具有第一通道与第一滤波器模块以从输出信号中滤出具有短脉冲宽度的第一信号，以及具有第二滤波器模块的第二通道 从输出信号中滤出具有较大脉冲宽度的第二信号。 具有比较器模块的控制器模块确定第一信号是否达到第一阈值，并且处理模块确定第二信号是否满足预定义的第二信号准则。

公开(公告)号：US08357544B2

公开(公告)日：2013-01-22

申请号：US11488473

申请日：2006-07-18

申请人： Nikolaus Ingenhoven ,  Robert Liebhard ,  Adi Zuppiger ,  Werner Hälg

发明人： Nikolaus Ingenhoven ,  Robert Liebhard ,  Adi Zuppiger ,  Werner Hälg

IPC分类号： G01N1/10

CPC分类号： G01N1/14 ,  B01L3/021 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2400/0487 ,  G01N35/1016 ,  G01N2035/1025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/2575

摘要： The present invention relates to a method for classifying a liquid (1) in a known pipetting system for this liquid (1), the method being characterized in that the changes of a selected, measurable, and physically founded virtual parameter are detected as a data set typical for this liquid (1); this typical data set of the selected virtual parameter is compared to corresponding data sets of known liquids, and the liquid (1) is classified on the basis of this comparison. An especially preferred method and a device for classifying a liquid (1) relate to a device which comprises a fluid chamber (2), to which a measuring chamber (3) is connected, whose internal pressure is monitored using a pressure transducer (4). At least a first part (5) of this fluid chamber (2) may be brought into fluid connection with a sample (6) of this liquid (1).

摘要翻译： 本发明涉及一种用于对该液体（1）的已知吸移系统中的液体（1）进行分类的方法，其特征在于，将所选择的，可测量的和物理上建立的虚拟参数的变化作为数据被检测 为这种液体（1）设定典型; 将所选虚拟参数的典型数据集与已知液体的相应数据集进行比较，并且基于该比较对液体（1）进行分类。 用于分类液体（1）的特别优选的方法和装置涉及一种包括流体室（2）的装置，其中连接有测量室（3），其内部压力使用压力传感器（4）监测， 。 该流体室（2）的至少第一部分（5）可以与该液体（1）的样品（6）流体连接。

公开(公告)号：US08215826B2

公开(公告)日：2012-07-10

申请号：US11913363

申请日：2006-05-04

申请人： Adi Zuppiger ,  Roland Fuchs ,  Urs Knecht

发明人： Adi Zuppiger ,  Roland Fuchs ,  Urs Knecht

IPC分类号： B01F11/00 ,  B01F11/02 ,  B65H1/00

CPC分类号： B01F11/0014 ,  B01F11/0022 ,  B01F11/0034 ,  B01F2215/0037

摘要： A method according to Claim 25, wherein essentially homogeneous material mixtures are achieved or maintained in these liquid containers.

摘要翻译： 26.根据权利要求25的方法，其中在这些液体容器中实现或维持基本均匀的材料混合物。