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1.发明申请公开(公告)号：US20200239593A1
公开(公告)日：2020-07-30
申请号：US16733376
申请日：2020-01-03
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Hergen SPITS , Tim BEAUMONT , Marijn Aletta GILLISSEN , Adrianus Quirinus BAKKER , Mette Deborah HAZENBERG , Martijn KEDDE
Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.
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公开(公告)号：US20170313766A1
公开(公告)日：2017-11-02
申请号：US15645399
申请日：2017-07-10
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Hergen SPITS , Tim BEAUMONT , Mark Jeroen KWAKKENBOS , Arjen Quirinus BAKKER
IPC: C07K16/10 , G01N33/569 , A61K39/00
CPC classification number: C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56983
Abstract: The invention relates to isolated, synthetic or recombinant antibodies and functional parts thereof specific for multiple influenza A virus subtypes. The invention further relates to the use of such antibodies for diagnosis of an influenza A virus infection and as a medicament and/or prophylactic agent for at least in part treating or alleviating symptoms of an influenza A virus infection.
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公开(公告)号：US20170313764A1
公开(公告)日：2017-11-02
申请号：US15508570
申请日：2015-09-07
Applicant: AIMM THERAPEUTICS B.V.
IPC: C07K16/10
CPC classification number: C07K16/109 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to isolated, synthetic or recombinant antibodies and functional parts thereof specific for hepatitis C virus (HCV). The invention further relates to the use of such antibodies for diagnosis, treatment and prevention of HCV infection.
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公开(公告)号：US20160222096A1
公开(公告)日：2016-08-04
申请号：US14981643
申请日：2015-12-28
Applicant: Genentech, Inc. , AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L.W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
IPC: C07K16/12
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US20150203816A1
公开(公告)日：2015-07-23
申请号：US14669916
申请日：2015-03-26
Inventor： Hergen SPITS
IPC: C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines arc also provided, as well as methods for producing antibodies using such cells and/or cell lines.
Abstract translation: 本发明提供了影响抗体产生细胞的稳定性的方法，其包括直接或间接地影响所述抗体产生细胞内的BCL6和/或Blimp1表达产物的量。 还提供了稳定的抗体产生细胞和细胞系，以及使用这种细胞和/或细胞系产生抗体的方法。
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Patent Agency Ranking
公开(公告)号：US20220064323A1
公开(公告)日：2022-03-03
申请号：US17476650
申请日：2021-09-16
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen SPITS , Paula Maria Wilhelmina VAN HELDEN , Remko SCHOTTE , Wouter POS , Christien FATMAWATI , Danïel Michiel GO , Koen WAGNER , Julien Christian VILLAUDY
IPC: C07K16/28 , A61P35/00 , C07K14/705 , G01N33/574
Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.
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公开(公告)号：US10690658B2
公开(公告)日：2020-06-23
申请号：US15316419
申请日：2015-06-05
Applicant: AIMM Therapeutics B.V. , Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis
Inventor： Carsten Linnemann , Laura Bies , Marit Martha van Buuren , Antonius Nicolaas Maria Schumacher , Hergen Spits , Remko Schotte
IPC: C12N5/00 , C12N5/02 , G01N33/50 , A61K39/00 , G01N33/569
Abstract: The invention provides improved screening methods for testing T cell recognition of T cell epitopes.
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公开(公告)号：US09969795B2
公开(公告)日：2018-05-15
申请号：US14956919
申请日：2015-12-02
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Hergen Spits , Adrianus Quirinus Bakker , Koen Wagner
CPC classification number: C07K16/1018 , C07K14/4703 , C07K14/4747 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/92
Abstract: The invention provides means and methods for producing high-affinity antibodies against an antigen of interest, usually stable B-cell cultures.
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公开(公告)号：US09688745B2
公开(公告)日：2017-06-27
申请号：US14981643
申请日：2015-12-28
Applicant: Genentech, Inc. , AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US20170160269A1
公开(公告)日：2017-06-08
申请号：US15316419
申请日：2015-06-05
Applicant: AIMM Therapeutics B.V. , Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis
Inventor： Carsten Linnemann , Laura Bies , Marit Martha van Buuren , Antonius Nicolaas Maria Schumacher , Hergen Spits , Remko Schotte
IPC: G01N33/50 , G01N33/569 , A61K39/00
Abstract: The invention provides improved screening methods for testing T cell recognition of T cell epitopes.
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