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1.发明申请公开(公告)号：US20200239593A1
公开(公告)日：2020-07-30
申请号：US16733376
申请日：2020-01-03
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Hergen SPITS , Tim BEAUMONT , Marijn Aletta GILLISSEN , Adrianus Quirinus BAKKER , Mette Deborah HAZENBERG , Martijn KEDDE
Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.
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公开(公告)号：US20170313766A1
公开(公告)日：2017-11-02
申请号：US15645399
申请日：2017-07-10
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Hergen SPITS , Tim BEAUMONT , Mark Jeroen KWAKKENBOS , Arjen Quirinus BAKKER
IPC: C07K16/10 , G01N33/569 , A61K39/00
CPC classification number: C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56983
Abstract: The invention relates to isolated, synthetic or recombinant antibodies and functional parts thereof specific for multiple influenza A virus subtypes. The invention further relates to the use of such antibodies for diagnosis of an influenza A virus infection and as a medicament and/or prophylactic agent for at least in part treating or alleviating symptoms of an influenza A virus infection.
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公开(公告)号：US20150203816A1
公开(公告)日：2015-07-23
申请号：US14669916
申请日：2015-03-26
Inventor： Hergen SPITS
IPC: C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines arc also provided, as well as methods for producing antibodies using such cells and/or cell lines.
Abstract translation: 本发明提供了影响抗体产生细胞的稳定性的方法，其包括直接或间接地影响所述抗体产生细胞内的BCL6和/或Blimp1表达产物的量。 还提供了稳定的抗体产生细胞和细胞系，以及使用这种细胞和/或细胞系产生抗体的方法。
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4.发明申请MEANS AND METHODS FOR COUNTERACTING MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISORDERS 审中-公开逆转髓磷脂或淋巴细胞增多症的手段和方法公开(公告)号：US20160326261A1
公开(公告)日：2016-11-10
申请号：US15105076
申请日：2014-12-17
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Hergen SPITS , Tim BEAUMONT , Marijn Aletta GILLISSEN , Adrianus Quirinus BAKKER , Mette Deborah Hazenberg
IPC: C07K16/30 , G01N33/574 , C12P21/00 , A61K47/48 , C07K16/40
Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.
Abstract translation: 本发明提供能够结合AML细胞的细胞表面组分的人类AML特异性结合化合物。 还提供了针对AML的结合化合物的治疗用途。
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公开(公告)号：US20220064323A1
公开(公告)日：2022-03-03
申请号：US17476650
申请日：2021-09-16
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen SPITS , Paula Maria Wilhelmina VAN HELDEN , Remko SCHOTTE , Wouter POS , Christien FATMAWATI , Danïel Michiel GO , Koen WAGNER , Julien Christian VILLAUDY
IPC: C07K16/28 , A61P35/00 , C07K14/705 , G01N33/574
Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.
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Patent Agency Ranking
公开(公告)号：US20170009205A1
公开(公告)日：2017-01-12
申请号：US15106991
申请日：2014-12-24
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Pauline Maria Wilhelmina VAN HELDEN , Mark Jeroen KWAKKENBOS , Hergen SPITS , Tim BEAUMONT
IPC: C12N5/0781 , C07K16/10 , C12P21/00 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C07K16/1018 , C07K2317/14 , C12N15/86 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12N2740/13045 , C12N2810/6054 , C12P21/005
Abstract: The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.
Abstract translation: 本发明提供用于生产具有短加倍时间的改进的离体B细胞培养物的方法和方法。
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公开(公告)号：US20160194382A1
公开(公告)日：2016-07-07
申请号：US15048339
申请日：2016-02-19
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Tim BEAUMONT , Mark Jeroen KWAKKENBOS , Hergen SPITS , Adrianus Quirinus BAKKER
IPC: C07K16/10
CPC classification number: C07K16/1027 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
Abstract: The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.
Abstract translation: 本发明提供用于调节抗体产生浆细胞样B细胞中体细胞超突变的发生的方法和方法。
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公开(公告)号：US20190023803A1
公开(公告)日：2019-01-24
申请号：US16068742
申请日：2017-01-06
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen SPITS , Paula Maria Wilhelmina VAN HELDEN , Remko SCHOTTE , Wouter POS , Christien FATMAWATI , Danïel Michiel GO , Koen WAGNER , Julien Christian VILLAUDY
IPC: C07K16/28 , C07K14/705 , G01N33/574 , A61P35/00
Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.
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公开(公告)号：US20180371410A1
公开(公告)日：2018-12-27
申请号：US16114483
申请日：2018-08-28
Inventor： Hergen SPITS
IPC: C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US20180170998A1
公开(公告)日：2018-06-21
申请号：US15737924
申请日：2016-06-24
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Hergen SPITS , Marijn Aletta GILLISSEN , Martijn KEDDE , Mette Deborah HAZENBERG , Paula Maria Wilhelmina van HELDEN , Wouter POS
IPC: C07K14/705 , C07K16/28 , G01N33/574
CPC classification number: C07K14/70596 , A61K38/00 , C07K14/435 , C07K16/2896 , C07K2317/732 , C07K2317/734 , G01N33/57426 , G01N2333/70596
Abstract: The present invention provides novel compounds comprising an antigen of AML cells, and uses thereof.
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