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公开(公告)号：US10690658B2
公开(公告)日：2020-06-23
申请号：US15316419
申请日：2015-06-05
Applicant: AIMM Therapeutics B.V. , Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis
Inventor： Carsten Linnemann , Laura Bies , Marit Martha van Buuren , Antonius Nicolaas Maria Schumacher , Hergen Spits , Remko Schotte
IPC: C12N5/00 , C12N5/02 , G01N33/50 , A61K39/00 , G01N33/569
Abstract: The invention provides improved screening methods for testing T cell recognition of T cell epitopes.
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公开(公告)号：US09969795B2
公开(公告)日：2018-05-15
申请号：US14956919
申请日：2015-12-02
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Hergen Spits , Adrianus Quirinus Bakker , Koen Wagner
CPC classification number: C07K16/1018 , C07K14/4703 , C07K14/4747 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/92
Abstract: The invention provides means and methods for producing high-affinity antibodies against an antigen of interest, usually stable B-cell cultures.
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公开(公告)号：US20170160269A1
公开(公告)日：2017-06-08
申请号：US15316419
申请日：2015-06-05
Applicant: AIMM Therapeutics B.V. , Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis
Inventor： Carsten Linnemann , Laura Bies , Marit Martha van Buuren , Antonius Nicolaas Maria Schumacher , Hergen Spits , Remko Schotte
IPC: G01N33/50 , G01N33/569 , A61K39/00
Abstract: The invention provides improved screening methods for testing T cell recognition of T cell epitopes.
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公开(公告)号：US10774308B2
公开(公告)日：2020-09-15
申请号：US16114483
申请日：2018-08-28
Inventor： Hergen Spits
IPC: A61K38/00 , C07K16/00 , C12N5/18 , C12N5/0781
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US11136407B2
公开(公告)日：2021-10-05
申请号：US16068742
申请日：2017-01-06
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen Spits , Paula Maria Wilhelmina Van Helden , Remko Schotte , Wouter Pos , Christien Fatmawati , Danïel Michiel Go , Koen Wagner , Julien Christian Villaudy
IPC: C07K16/28 , G01N33/574 , A61P35/00 , C07K14/705 , A61K39/00
Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.
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Patent Agency Ranking
公开(公告)号：US10556963B2
公开(公告)日：2020-02-11
申请号：US15105076
申请日：2014-12-17
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen Spits , Tim Beaumont , Marijn Aletta Gillissen , Adrianus Quirinus Bakker , Mette Deborah Hazenberg , Martijn Kedde
Abstract: The invention provides human AML-specific binding compounds that are able to bind a cell surface component of AML cells. Therapeutic uses of binding compounds against AML are also provided.
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公开(公告)号：US10344076B2
公开(公告)日：2019-07-09
申请号：US15048339
申请日：2016-02-19
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Hergen Spits , Adrianus Quirinus Bakker
Abstract: The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.
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公开(公告)号：US10273454B2
公开(公告)日：2019-04-30
申请号：US15612096
申请日：2017-06-02
Inventor： Hergen Spits , Ferenc A. Scheeren , Tim Beaumont , Sean A. Diehl
IPC: C12N5/10 , C12N5/0781 , C07K16/00
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US20200149007A1
公开(公告)日：2020-05-14
申请号：US16575518
申请日：2019-09-19
Applicant: AIMM THERAPEUTICS B.V.
IPC: C12N5/0781 , C12P21/00 , C07K16/10 , C07K16/00 , C12N15/86
Abstract: The present invention provides means and methods for producing improved ex vivo B cell cultures with a short doubling time.
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公开(公告)号：US10077427B2
公开(公告)日：2018-09-18
申请号：US14669916
申请日：2015-03-26
Inventor： Hergen Spits
IPC: C12N5/06 , C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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