公开(公告)号：US20190064166A1

公开(公告)日：2019-02-28

申请号：US15752230

申请日：2016-08-12

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Jonathan BARASCH ,  Katherine XU ,  Paul ROSENSTIEL ,  Paolo GUARNIERI

IPC分类号： G01N33/573 ,  G01N33/68 ,  G01N33/70

摘要： The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TAC-STD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.

公开(公告)号：US20240351928A1

公开(公告)日：2024-10-24

申请号：US18637984

申请日：2024-04-17

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Julian John Alexander VAN DER MADE ,  Kartik CHANDRAN ,  Elizabetth Amy LANDIS ,  Ruby LAI

IPC分类号： C02F3/34 ,  C02F1/467 ,  C02F1/72 ,  C02F101/34 ,  C02F101/36 ,  C02F103/34 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  C12M1/42 ,  C12N1/14

CPC分类号： C02F3/347 ,  C02F1/4672 ,  C02F1/722 ,  C12M25/02 ,  C12M27/06 ,  C12M29/06 ,  C12M35/02 ,  C12N1/14 ,  C02F2101/34 ,  C02F2101/36 ,  C02F2103/34 ,  C02F2305/026

摘要： A fungal culture is provided that incorporates concentrations of Fenton reactants and white rot fungi biomass. These components synergize to degrade recalcitrant organic compounds such as lignins, perfluorochemicals including PFOA, plastics, and related compounds, particularly with 1.5 mM H2O2, 1 mM Fe2+, and Phanerochaete chrysosporium exhibiting lignin degrading capabilities comparable to cultures of Fenton-only reaction mediums with significantly higher concentrations of hydrogen peroxide. Both the fungi and the Fenton reactants work to degrade the organic compounds. Additionally, the Fenton reactants impose oxidative stress on fast-growing microbial competitors such as E. coli, selectively inhibiting the competing bacteria and their disadvantageous effects on white rot fungi activity. The white rot fungi recycle Fe(II) ions to reduce Fenton reactant input burden. An electro-Fenton reaction process can further reduce this burden by replenishing H2O2. The resulting systems and methods demonstrate more economical and sustainable treatment of recalcitrant organic compounds.

公开(公告)号：US12125593B2

公开(公告)日：2024-10-22

申请号：US17494562

申请日：2021-10-05

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Paul Sajda ,  Xueqing Liu

IPC分类号： G16H50/20 ,  G06T7/00 ,  G06T9/00

CPC分类号： G16H50/20 ,  G06T7/0012 ,  G06T9/002 ,  G06T2207/10088

摘要： The present subject matter relates to techniques for hierarchical deep transcoding. The disclosed system can include a processor that can be configured to receive a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and reconstruct a latent source space from the fMRI data and/or the EEG data by decoding the EEG data and/or the fMRI data to a latent source space. The fMRI data and the EEG data can be simultaneously acquired.

公开(公告)号：US12123005B2

公开(公告)日：2024-10-22

申请号：US16508021

申请日：2019-07-10

申请人： The Trustees of Columbia University in the City of New York

发明人： Antonio Iavarone ,  Anna Lasorella ,  Raul Rabadan

IPC分类号： C12Q1/6886 ,  C07K14/47 ,  C07K14/71 ,  C07K14/82 ,  C07K16/18 ,  C07K16/28 ,  C12N9/12 ,  C12N15/62 ,  G01N33/574

CPC分类号： C12N15/62 ,  C07K14/47 ,  C07K14/71 ,  C07K14/82 ,  C07K16/18 ,  C07K16/2863 ,  C12N9/12 ,  C12Q1/6886 ,  G01N33/57492 ,  C07K2319/00 ,  C07K2319/73 ,  C12Q2600/158 ,  G01N2333/91205

摘要： The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.

公开(公告)号：US20240348172A1

公开(公告)日：2024-10-17

申请号：US18292315

申请日：2022-07-27

申请人： The Trustees of Columbia University in the City of New York

发明人： Matthias Preindl ,  Liwei Zhou ,  William-Michael Eull ,  Matthew Jahnes

IPC分类号： H02M3/335 ,  H02M1/00 ,  H02M1/12 ,  H02M1/14 ,  H02M1/44 ,  H02M3/00 ,  H02M7/797

CPC分类号： H02M3/33571 ,  H02M1/0058 ,  H02M1/126 ,  H02M1/14 ,  H02M3/01 ,  H02M7/797 ,  H02M1/009 ,  H02M1/44 ,  H02M3/33584

摘要： Systems and methods for a high-efficiency power converter incorporating a half-bridge topology with one or more an additional upper capacitor and a drain-source capacitor. The converter includes DC voltage terminals and a DC link capacitor coupled across a positive and negative DC terminal of the DC voltage terminals. The converter further includes a power switching element pair including a high side switch and a low side switch coupled together at a midpoint node. The converter further includes an LC filter having a switch-side inductor, a lower capacitor coupled between a second end of switch-side inductor and the negative DC terminal; and an upper capacitor coupled between the second end of the switch-side inductor and the positive DC terminal. The converter may further include drain-source capacitors coupled across the drain and source terminals of the switches.

公开(公告)号：US20240343781A1

公开(公告)日：2024-10-17

申请号：US18291530

申请日：2022-07-22

申请人： The Trustees of Columbia University in the City of New York

发明人： David D. HO ,  Yaoxing HUANG ,  Lihong LIU ,  Manoj S. NAIR ,  Jian YU ,  Sho IKETANI

IPC分类号： C07K16/10 ,  A61P31/20

CPC分类号： C07K16/1003 ,  A61P31/20 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The subject matter described herein relates to engineered monoclonal antibodies, derived from antibodies isolated from human patients, neutralizing a SARS-CoV-2 virus, its variants, or related coronaviruses.

公开(公告)号：US12115140B2

公开(公告)日：2024-10-15

申请号：US17391853

申请日：2021-08-02

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Piero D. Dalerba ,  Sara Viragova

IPC分类号： A61K31/192 ,  A61K31/203

CPC分类号： A61K31/192 ,  A61K31/203

摘要： The method of treating adenoid cystic carcinoma or other cancer tumors includes the administration of an effective dosage of an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling to a patient in need thereof, alone or in combination with other cancer treatment. Non-limiting examples of an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling include 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid (commonly referred to as “BMS493”) and 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl] ethynyl]benzoic acid (commonly referred to as “AGN193109”). Alternatively, prior to administration of the inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling, a direct agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling may be administered to the patient. Non-limiting examples of a direct agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling include all-trans retinoic acid (ATRA), isotretinoin, alitretinoin, and bexarotene.

公开(公告)号：US20240337825A1

公开(公告)日：2024-10-10

申请号：US18435404

申请日：2024-02-07

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK CITY

发明人： Jyotirmoy MANDAL ,  Yuan YANG ,  Nanfang YU

IPC分类号： G02B26/00 ,  C08J9/28 ,  C08K5/00 ,  C09D5/33 ,  E04D7/00 ,  E04D13/00 ,  E04F13/08 ,  E06B9/24 ,  G02B1/14 ,  G02B5/20

CPC分类号： G02B26/004 ,  C08J9/286 ,  C08K5/0041 ,  C09D5/004 ,  E04D7/00 ,  E04D13/00 ,  E04F13/08 ,  E06B9/24 ,  G02B1/14 ,  G02B5/208 ,  B32B2305/026 ,  C08J2301/12 ,  C08J2301/28 ,  C08J2325/06 ,  C08J2327/06 ,  C08J2327/14 ,  C08J2327/20 ,  C08J2383/04 ,  E06B2009/2411 ,  E06B2009/2417

摘要： A switchable light transmission module is disclosed that includes a substrate having a first surface defining at least part of an enclosed volume, a porous layer disposed on the first surface and in fluid communication with the enclosed volume, and a reservoir in fluid communication with the enclosed volume. The reservoir is configured to supply a fluid to the sealed volume such that the fluid contacts the porous layer. The fluid has a refractive index that is close to the refractive index of the porous layer, has a high wettability for the porous layer, and does not dissolve the porous layer. When in a dry state, voids in the porous layer are filled with air which has a much different refractive index than the porous layer itself, resulting in a surface that is reflective and not very transmissive. During wetting of the porous layer by the fluid, however, those voids are filled with the fluid, reducing the difference in refractive index across the polymer-fluid interfaces such that light scattering is negligible and the surface becomes light permeable.

公开(公告)号：US12104114B2

公开(公告)日：2024-10-01

申请号：US16917758

申请日：2020-06-30

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  CARNEGIE MELLON UNIVERSITY

发明人： Colin Nuckolls ,  Jingjing Yang ,  Alexander D. Christodoulides ,  Boyuan Zhang ,  Qizhi Xu ,  Amirali Zangiabadi ,  Christine McGinn ,  Samuel Peurifoy ,  Lingyun Dai ,  Elena Meirzadeh ,  Michael Steigerwald ,  Xavier Roy ,  Ioannis Kymissis ,  Jonathan A. Malen

IPC分类号： C09K5/14 ,  C09D5/00

CPC分类号： C09K5/14 ,  C09D5/00

摘要： Ionic superatomic materials that can be solution-processed into completely amorphous and homogeneous thin films are disclosed herein. The amorphous materials disclosed herein have tunable compositions and have electrical conductivities of up to 300 siemens per meter, thermal conductivities of 0.05 watt per meter per degree Kelvin, and optical transparencies of up to 92%. Application of these thin-films are also provided herein.

公开(公告)号：US12100121B2

公开(公告)日：2024-09-24

申请号：US17347948

申请日：2021-06-15

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Jia Guo ,  Scott A. Small

IPC分类号： G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50

CPC分类号： G06T5/00 ,  G06T5/50 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50 ,  G06T2207/10096 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30016

摘要： An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.