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公开(公告)号：US20170210843A1
公开(公告)日：2017-07-27
申请号：US15329534
申请日：2015-07-24
申请人： Suprapolix B.V.
CPC分类号： C08G18/506 , A61K8/87 , A61K9/0019 , A61K9/0024 , A61K47/10 , A61K47/34 , A61K2800/10 , A61L24/0031 , A61L26/008 , A61L27/52 , A61Q19/00 , C08G18/755 , C08G18/758 , C08G65/329 , C08G65/333 , C08G65/33303 , C08G65/33348 , C08G65/33396 , C08G2210/00 , C08G2650/04 , C08G2650/50 , C08L2203/02
摘要： This disclosure relates to new injectable hydrogel materials that consist of water gellants comprising linear hydrophilic polymers that comprise hydrogen bonding units in the backbone combined with cross-linkable end groups, resulting in dynamic yet firm hydrogel materials that are easily processable, are highly elastic, show adhesive properties and are self-healing and are especially suitable for biomedical applications.
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公开(公告)号：US11884781B2
公开(公告)日：2024-01-30
申请号：US16877980
申请日：2020-05-19
申请人： SupraPolix B.V.
IPC分类号： A61L27/18 , A61L27/58 , C08G18/10 , C08G18/12 , C08G18/32 , C08G18/38 , C08G18/42 , C08G18/66 , C08G18/73 , C08G83/00 , C08L101/00 , A61L27/56 , A61L31/06 , A61L31/14
CPC分类号： C08G83/008 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , C08G18/3206 , C08G18/73 , C08G2230/00
摘要： The present invention relates to supramolecular biomedical polymers comprising quadruple hydrogen bonding units and to a process for preparing such a supramolecular biomedical polymer and porous biomedical implants thereof. The supramolecular biomedical polymers are particularly suitable for the production of porous biomedical implants that need high strength, elasticity, durability, and slow biodegradation, e.g. medical implants for living tissue regeneration within a mammal, such as the treatment of cardio-vascular diseases, medical prolapses, and hernias.
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3.发明授权Modular bioresorbable or biomedical, biologically active supramolecular materials 有权模块化生物可吸收或生物医学，生物活性超分子材料公开(公告)号：US09339586B2
公开(公告)日：2016-05-17
申请号：US14527690
申请日：2014-10-29
申请人： SupraPolix B.V.
发明人： Patricia Yvonne Wilhelmina Dankers , Gaby Maria Leonarda van Gemert , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
IPC分类号： A61L27/18 , A61L27/58 , A61L31/06 , C08G83/00 , C08G18/48 , C08G18/67 , C08G18/73 , C08G18/42 , A61L27/34
CPC分类号： A61F2/00 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/224 , A61L2300/236 , A61L2300/25 , A61L2420/06 , C08G18/246 , C08G18/3848 , C08G18/4202 , C08G18/4238 , C08G18/4277 , C08G18/4833 , C08G18/672 , C08G18/73 , C08G18/755 , C08G83/008 , Y10S623/916 , Y10S623/926
摘要： The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or biomedical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.
摘要翻译： 本发明涉及模块化超分子生物可再吸收或生物医学材料，其包含（i）包含至少两个4H-单元的聚合物和（ii）生物活性化合物。 任选地，超分子生物可再吸收或生物医学材料包括生物可再吸收或生物医学聚合物作为调节其性质（机械和生物吸收性质）的第三组分。 超分子生物可吸收或生物医学材料特别适用于生物医学应用，例如药物的控制释放，用于组织工程的材料，用于制造假体或植入物的材料，医学成像技术。
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公开(公告)号：US20160115272A1
公开(公告)日：2016-04-28
申请号：US14891111
申请日：2014-05-14
申请人： SUPRAPOLIX B.V.
发明人： Tristan MES , Anton Willem BOSMAN
CPC分类号： C08G18/6607 , A61L27/18 , A61L27/58 , C08G18/10 , C08G18/12 , C08G18/6637 , C08G18/6674 , C08G18/73 , C08G83/008 , C08G2230/00 , C08L101/005 , C08G18/4277 , C08G18/3848 , C08G18/3206
摘要： The present invention relates to a supramolecular biodegradable polymer comprising a quadruple hydrogen bonding unit (abbreviated herein as “4H-unit”), a biodegradable backbone and hard blocks and a process for preparing such a supramolecular biodegradable polymer. The supramolecular polymer is specifically suitable for biodegradable articles such as biomedical implants that need high strength and/or elasticity, e.g. medical implants in the cardio-vascular field.
摘要翻译： 本发明涉及包含四氢氢键单元（本文简称为“4H-单元”），可生物降解的主链和硬嵌段的超分子生物可降解聚合物以及制备这种超分子生物可降解聚合物的方法。 超分子聚合物特别适用于生物降解制品，例如需要高强度和/或弹性的生物医学植入物，例如。 医学植入物在心血管领域。
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公开(公告)号：US08268952B2
公开(公告)日：2012-09-18
申请号：US11571960
申请日：2005-07-11
申请人： Gaby Maria Leonarda Van Gemert , Ronny Mathieu Versteegen , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
发明人： Gaby Maria Leonarda Van Gemert , Ronny Mathieu Versteegen , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
CPC分类号： C08G83/008 , B33Y70/00 , C08G18/0819 , C08G18/3293 , C08G18/3848 , C08G18/8041
摘要： The invention relates to supramolecular ionomers. i.e. polymers having quadruple hydrogen bonding units (4H-units) and ionic groups or ionogenic groups within their structure. The supramolecular ionomers can be dispersed or solubilized in water at high solids contents while maintaining low viscosities, facilitating easy use and processing of the resulting aqueous formulations. The aqueous supramolecular ionomer compositions have excellent film-forming properties. Moreover, the polymer materials have good mechanical properties after drying, as they are not tacky, show high elasticity and low or no creep.
摘要翻译： 本发明涉及超分子离聚物。 即在其结构内具有四重氢键合单元（4H-单元）和离子基团或离子基团的聚合物。 超分子离子聚合物可以以高固体含量分散或溶解在水中，同时保持低粘度，便于使用和处理所得含水制剂。 超分子离子交换水分子组合物具有优异的成膜性能。 此外，聚合物材料在干燥后具有良好的机械性能，因为它们不发粘，显示出高弹性和低或无蠕变。
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公开(公告)号：US20090004274A1
公开(公告)日：2009-01-01
申请号：US11913466
申请日：2006-05-03
申请人： Gaby Maria Hoorne-Van Gemert , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
发明人： Gaby Maria Hoorne-Van Gemert , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
IPC分类号： A61K9/00 , C08L101/02
CPC分类号： A61K8/73 , A61K8/042 , A61K8/736 , A61K8/8152 , A61K8/86 , A61K8/90 , A61K9/0058 , A61K9/06 , A61K47/6903 , A61Q19/00 , C08L101/14
摘要： The present invention relates to new hydrogel materials using water gellants that are comprised by hydrophilic polymers to which hydrogen bonding units are covalently attached. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and functionality and are especially suitable for cosmetic and biomedical applications.
摘要翻译： 本发明涉及使用由氢键单元共价连接的亲水性聚合物构成的水凝胶的新水凝胶材料。 任选地，水凝胶含有另外的成分或添加剂。 这些新的可逆水凝胶可以在其机械性能和功能上轻松调整，特别适用于化妆品和生物医学应用。
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公开(公告)号：US10377847B2
公开(公告)日：2019-08-13
申请号：US14152688
申请日：2014-01-10
申请人： SupraPolix B.V.
发明人： Travis Wayne Baughman , Gaby Maria Leonarda Hoorne-Van Gemert , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
IPC分类号： A61K9/06 , A61K47/18 , A61K47/22 , A61K47/32 , A61K47/34 , C08G18/42 , C08G18/48 , C08G18/62 , C08G69/00 , C08G69/28 , C08G69/40 , C08G69/44 , C08G71/04 , C08G75/00
摘要： The present invention relates to improved hydrogel materials using water gellants that are comprised of polymer backbones P to which hydrogen bonding 4H-units are covalently attached via a hydrophobic linker L. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and function and are especially suitable for biomedical applications.
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8.发明授权Supramolecular polymers from low-melting, easily processable building blocks 有权超分子聚合物由低熔点，易加工的结构单元组成公开(公告)号：US09006364B2
公开(公告)日：2015-04-14
申请号：US14057893
申请日：2013-10-18
申请人： SupraPolix B.V.
发明人： Gaby Maria Leonarda Van Gemert , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
IPC分类号： C08F226/06 , C08G77/388 , C08G18/10 , C08G18/32 , C08G18/38 , C08G18/42 , C08G18/73 , C08G18/78 , C08G83/00 , C08G18/81 , C08G64/42
CPC分类号： C08G77/388 , C08G18/10 , C08G18/3212 , C08G18/3848 , C08G18/4238 , C08G18/4277 , C08G18/73 , C08G18/7887 , C08G18/8108 , C08G64/42 , C08G83/008
摘要： The present invention relates to a supramolecular polymer comprising 1-50 4H-units, said supramolecular polymer being obtainable by reacting at least one monomeric building block with a prepolymer. The present invention further relates to articles or compositions comprising the supramolecular polymer, in particular articles or compositions selected from the group consisting of decorative, thermo-reversible, or self-healing coatings, adhesive compositions, sealing compositions, thickeners, gelators and binders.
摘要翻译： 本发明涉及包含1-50H 4单元的超分子聚合物，所述超分子聚合物可通过使至少一种单体结构单元与预聚物反应而获得。 本发明还涉及包含超分子聚合物的制品或组合物，特别是选自装饰性，热可逆或自愈合涂层，粘合剂组合物，密封组合物，增稠剂，凝胶剂和粘合剂的制品或组合物。
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9.发明申请MODULAR BIORESORBABLE OR BIOMEDICAL, BIOLOGICALLY ACTIVE SUPRAMOLECULAR MATERIALS 审中-公开生物多样性或生物医学，生物活性分子材料公开(公告)号：US20150057237A1
公开(公告)日：2015-02-26
申请号：US14527690
申请日：2014-10-29
申请人： SupraPolix B.V.
发明人： Patricia Yvonne Wilhelmina DANKERS , Gaby Maria Leonarda HOORNE-VAN GEMERT , Henricus Marie JANSSEN , Egbert Willem MEIJER , Anton Willem BOSMAN
CPC分类号： A61F2/00 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/224 , A61L2300/236 , A61L2300/25 , A61L2420/06 , C08G18/246 , C08G18/3848 , C08G18/4202 , C08G18/4238 , C08G18/4277 , C08G18/4833 , C08G18/672 , C08G18/73 , C08G18/755 , C08G83/008 , Y10S623/916 , Y10S623/926
摘要： The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or biomedical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.
摘要翻译： 本发明涉及模块化超分子生物可再吸收或生物医学材料，其包含（i）包含至少两个4H-单元的聚合物和（ii）生物活性化合物。 任选地，超分子生物可再吸收或生物医学材料包括生物可再吸收或生物医学聚合物作为调节其性质（机械和生物吸收性质）的第三组分。 超分子生物可吸收或生物医学材料特别适用于生物医学应用，例如药物的控制释放，用于组织工程的材料，用于制造假体或植入物的材料，医学成像技术。
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公开(公告)号：US08754213B2
公开(公告)日：2014-06-17
申请号：US13002500
申请日：2009-07-06
申请人： Gaby Maria Leonarda Hoorne-van Gemert , Sandrine Chodorowski-Kimmès , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
发明人： Gaby Maria Leonarda Hoorne-van Gemert , Sandrine Chodorowski-Kimmès , Henricus Marie Janssen , Egbert Willem Meijer , Anton Willem Bosman
IPC分类号： C07D239/02 , C07D239/47 , C07D239/48
CPC分类号： C07D239/47 , C07D239/46 , C07D239/48 , C08G83/008 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31989 , Y10T428/31993
摘要： The present invention relates to a supramolecular compound comprising a low molecular weight, apolar compound, said low molecular weight, apolar compound having a melting point of below 45° C., a molecular weight of about 80 to about 1500 amu and a HLB-value of lower than 8, said low molecular weight, apolar compound bearing a single 4H-unit per molecule. The supramolecular compound according to the present invention may be used in coating, ink, toner, resin, lacquer, adhesive or glue compositions.
摘要翻译： 本发明涉及包含低分子量非极性化合物，所述低分子量，熔点低于45℃，分子量为约80至约1500amu的非极性化合物和HLB值的超分子化合物 低于8，所述低分子量，每分子具有单个4H-单元的非极性化合物。 根据本发明的超分子化合物可以用于涂料，油墨，调色剂，树脂，漆，粘合剂或胶组合物中。
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