HIGH FREQUENCY SENSITIVE NEURAL NETWORK
    3.
    发明公开

    公开(公告)号:US20240281642A1

    公开(公告)日:2024-08-22

    申请号:US18563388

    申请日:2022-05-26

    IPC分类号: G06N3/0464

    CPC分类号: G06N3/0464

    摘要: A computer-implemented method of extracting high-frequency features from data, including receiving a first dataset; in a training phase, applying frequency-based guidance to learnable high-frequency filters in a neural network, the frequency based-guidance including promoting high eigenvalues associated with eigenvectors comprising the learnable high-frequency filters; extracting from the first dataset high-frequency features associated with the eigenvectors; and using the trained high-frequency filters to extract high-frequency features from a second dataset.

    STEREOGRADIENT POLYESTER COPOLYMERS AND PROCESSES OF PREPARING SAME

    公开(公告)号:US20240262958A1

    公开(公告)日:2024-08-08

    申请号:US18619297

    申请日:2024-03-28

    IPC分类号: C08G63/82

    CPC分类号: C08G63/823

    摘要: Stereogradient polyesters and processes of preparing same are provided. The stererogradient polyesters are composed of at least two segments of a polyester, each segment being composed of at least a first plurality of backbone units of a first cyclic ester featuring a first stereoconfiguration and a second plurality of backbone units of a second cyclic ester featuring a second stereoconfiguration, the first and second stereoconfigurations being different from one another, whereby each of the at least two segments features a different mol ratio of the at least first and second pluralities of backbone units. The sterogradient polyesters are obtainable by contacting a mixture of the first cyclic ester and the second cyclic ester with a catalyst that exhibits a different kinetic parameter towards ring opening polymerization of each of the cyclic esters, under conditions that promote ring opening polymerization of the cyclic ester.

    Detection of hydroxymethylcytosine bases

    公开(公告)号:US12043863B2

    公开(公告)日:2024-07-23

    申请号:US17400168

    申请日:2021-08-12

    摘要: Provided herein is a method of labeling the epigenetic modification 5-hydroxymethyl-cytosine along a DNA molecule that involves attaching a 5-hydroxymethyl-cytosine specific labeling agent to the DNA molecule, which is effected by enzymatically synthesizing UDP-6-N3-Glucose by subjecting 6-azidoglucose to an enzymatic catalysis by N-acetylhexoseamine 1-kinase (NahK) in the presence of ATP to thereby obtain a phosphorylated 6-azidoglucose, followed by subjecting the phosphorylated 6-azidoglucose to enzymatic catalysis by uridyltransferase (GlmU) in the presence of UTP to thereby obtain UDP-6-N3-Glucose, followed by incubating the DNA molecule with UDP-6-N3-Glucose and ß-glucosyltransferase, to thereby obtain a 5-hydroxymethyl-cytosin e glycosylated by a 6-azidoglucose residue in the DNA molecule, and reacting the modified DNA molecule with a labeling agent which is chemically compatible with the azide group of the 6-azidoglucose residue.

    CONTENT-DRIVEN VIRTUAL AGENT FACILITATOR FOR ONLINE GROUP ACTIVITY

    公开(公告)号:US20240203279A1

    公开(公告)日:2024-06-20

    申请号:US18287036

    申请日:2022-05-03

    摘要: The disclosure is of a virtual agent (web based or robotic) for controlling group activities, such as learning and discussion. The aim is enhancing the effectivity of the activity by maintaining an effective, positive atmosphere and equitable participation.
    The agent applies multimodal input, comprising video and sound to monitor certain aspects of the group dynamics and their facets, pertaining to the users. Some aspects and facets thereof may trigger facilitation patterns, which may be performed using multimodal output.
    The agent uses a set of preset behavior, emotional patterns and facilitation patterns. The agent is trained using a dataset of recorded group activities and machine learning algorithms, and may apply online learning for optimization and personalization of the facilitation patterns and the associated enticers.