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公开(公告)号:US20240353397A1
公开(公告)日:2024-10-24
申请号:US18683168
申请日:2022-08-11
发明人: Irit GAT-VIKS , Eran BACHARACH , Gal YANKOVITZ , Ofir COHN , Naama PESHES-YALOZ
IPC分类号: G01N33/50 , A61K31/473 , A61K31/496
CPC分类号: G01N33/5091 , A61K31/473 , A61K31/496 , G01N33/5023
摘要: The present disclosure provides methods for evaluating the immunological state in a subject by determining the levels of resistance and/or disease tolerance of the subject, using specific signatory biomarkers for disease tolerance and resistance. The present disclosure further provides diagnostic compositions and kits, as well as therapeutic methods based on manipulating the expression of the disclosed resistance and/or disease-tolerance biomarkers to modulate the immunological state and disease outcome.
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公开(公告)号:US20240334076A1
公开(公告)日:2024-10-03
申请号:US18709524
申请日:2022-11-14
发明人: David Mendlovic , Dan Raviv , Khen Cohen , Lior Gelberg , Mor-Avi Azulay , Menahem Koren
CPC分类号: H04N25/47 , H04N23/56 , H04N23/74 , H04N23/84 , H04N25/707
摘要: A dynamic vision sensor (DVS) color camera (DVS-CCam) operable to acquire a color image of a scene, the DVS-CCam including a DVS photosensor comprising DVS pixels, an illuminator operable to transmit a light pattern characterized by temporal changes in intensity and color to illuminate a scene, an optical system configured to collect and focus on the pixels of the DVS photosensor light reflected by features in the scene from the light pattern transmitted by the illuminator, and a processor configured to process DVS signals generated by the DVS pixels responsive to temporal changes in the reflected light to provide a color image of the scene.
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公开(公告)号:US20240281642A1
公开(公告)日:2024-08-22
申请号:US18563388
申请日:2022-05-26
发明人: David Mendlovic , Dan Raviv , Lior Gelberg , Khen Cohen , Mor-Avi Azulay , Menahem Koren
IPC分类号: G06N3/0464
CPC分类号: G06N3/0464
摘要: A computer-implemented method of extracting high-frequency features from data, including receiving a first dataset; in a training phase, applying frequency-based guidance to learnable high-frequency filters in a neural network, the frequency based-guidance including promoting high eigenvalues associated with eigenvectors comprising the learnable high-frequency filters; extracting from the first dataset high-frequency features associated with the eigenvectors; and using the trained high-frequency filters to extract high-frequency features from a second dataset.
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公开(公告)号:US12065664B2
公开(公告)日:2024-08-20
申请号:US17128736
申请日:2020-12-21
IPC分类号: A61K39/395 , A61K9/00 , A61K9/51 , A61K31/105 , A61K31/7105 , A61K31/713 , A61K47/68 , A61K47/69 , A61K48/00 , A61P35/02 , C07K16/28 , C12N15/88
CPC分类号: C12N15/88 , A61K9/0019 , A61K9/513 , A61K31/105 , A61K31/7105 , A61K31/713 , A61K39/395 , A61K47/6849 , A61K47/6911 , A61K48/0066 , A61P35/02 , C07K16/2812 , C07K16/2896
摘要: Disclosed are targeted lipid based particles for delivery of nucleic acid molecules (such as siRNA) to leukocytes (such as T-Cells and B-cells). Further disclosed are uses of the targeted lipid based particles for treating Leukocytes-associated diseases, such as, cancer.
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公开(公告)号:US20240262958A1
公开(公告)日:2024-08-08
申请号:US18619297
申请日:2024-03-28
发明人: Moshe KOL , Rami HADOR , Michael SHUSTER
IPC分类号: C08G63/82
CPC分类号: C08G63/823
摘要: Stereogradient polyesters and processes of preparing same are provided. The stererogradient polyesters are composed of at least two segments of a polyester, each segment being composed of at least a first plurality of backbone units of a first cyclic ester featuring a first stereoconfiguration and a second plurality of backbone units of a second cyclic ester featuring a second stereoconfiguration, the first and second stereoconfigurations being different from one another, whereby each of the at least two segments features a different mol ratio of the at least first and second pluralities of backbone units. The sterogradient polyesters are obtainable by contacting a mixture of the first cyclic ester and the second cyclic ester with a catalyst that exhibits a different kinetic parameter towards ring opening polymerization of each of the cyclic esters, under conditions that promote ring opening polymerization of the cyclic ester.
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公开(公告)号:US20240249409A1
公开(公告)日:2024-07-25
申请号:US18561749
申请日:2022-05-18
发明人: Arnaldo MAYER , Tamir MANOR , Asaf HALLE , Nahum KIRYATI , Eliahu KONEN , Jana PICKOVSKY
CPC分类号: G06T7/0012 , G06T7/11 , G06T2207/10081 , G06T2207/20081 , G06T2207/20084 , G06T2207/30028
摘要: A method of analyzing an abdominal computed tomography (CT) scan comprises applying a colon segmentation machine learning procedure to the CT scan, and receiving from the colon segmentation machine learning procedure an output indicative of a plurality of colon segments. The method also comprises feeding the output into a colon lesion detection machine learning procedure, and receiving from the colon lesion detection machine learning procedure an output indicative of presence of at least one pathology in the colon.
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公开(公告)号:US12043863B2
公开(公告)日:2024-07-23
申请号:US17400168
申请日:2021-08-12
发明人: Yuval Ebenstein , Micha Fridman
IPC分类号: C12Q1/6806 , C12P19/30 , G01N21/64
CPC分类号: C12Q1/6806 , C12P19/305 , G01N21/6428 , C12Q1/6827 , C12Q2537/164
摘要: Provided herein is a method of labeling the epigenetic modification 5-hydroxymethyl-cytosine along a DNA molecule that involves attaching a 5-hydroxymethyl-cytosine specific labeling agent to the DNA molecule, which is effected by enzymatically synthesizing UDP-6-N3-Glucose by subjecting 6-azidoglucose to an enzymatic catalysis by N-acetylhexoseamine 1-kinase (NahK) in the presence of ATP to thereby obtain a phosphorylated 6-azidoglucose, followed by subjecting the phosphorylated 6-azidoglucose to enzymatic catalysis by uridyltransferase (GlmU) in the presence of UTP to thereby obtain UDP-6-N3-Glucose, followed by incubating the DNA molecule with UDP-6-N3-Glucose and ß-glucosyltransferase, to thereby obtain a 5-hydroxymethyl-cytosin e glycosylated by a 6-azidoglucose residue in the DNA molecule, and reacting the modified DNA molecule with a labeling agent which is chemically compatible with the azide group of the 6-azidoglucose residue.
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公开(公告)号:US20240203279A1
公开(公告)日:2024-06-20
申请号:US18287036
申请日:2022-05-03
发明人: Goren GORDON , Elinor MIZRAHI
CPC分类号: G09B5/06 , G06V40/174 , G10L15/22 , G10L25/63
摘要: The disclosure is of a virtual agent (web based or robotic) for controlling group activities, such as learning and discussion. The aim is enhancing the effectivity of the activity by maintaining an effective, positive atmosphere and equitable participation.
The agent applies multimodal input, comprising video and sound to monitor certain aspects of the group dynamics and their facets, pertaining to the users. Some aspects and facets thereof may trigger facilitation patterns, which may be performed using multimodal output.
The agent uses a set of preset behavior, emotional patterns and facilitation patterns. The agent is trained using a dataset of recorded group activities and machine learning algorithms, and may apply online learning for optimization and personalization of the facilitation patterns and the associated enticers.-
公开(公告)号:US20240197924A1
公开(公告)日:2024-06-20
申请号:US18428591
申请日:2024-01-31
发明人: Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC分类号: A61K49/00 , C07D321/00 , C07F5/02 , C07F5/04 , C07F7/18 , C07F9/12 , C07F9/655 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/01 , C09B23/04 , C09B23/08 , C09K11/06
CPC分类号: A61K49/0052 , C07D321/00 , C07F5/025 , C07F5/04 , C07F7/1804 , C07F9/12 , C07F9/65512 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/0066 , C09B23/04 , C09B23/083 , C09K11/06 , C09K2211/1018
摘要: The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号:US20240166729A1
公开(公告)日:2024-05-23
申请号:US17996013
申请日:2021-04-14
申请人: Ramot at Tel-Aviv University Ltd. , B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University
发明人: Yariv WINE , Neta SAL-MAN , Yaron HILLMAN , Dan LUSTIGER , Jenia GERSHBERG , Dan EVEN
IPC分类号: C07K16/12 , A61K39/00 , A61K45/06 , A61P31/04 , G01N33/569
CPC分类号: C07K16/1232 , A61K45/06 , A61P31/04 , G01N33/56916 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/565 , G01N2333/245
摘要: The invention relates to human antibodies specific for Type III secretion system (T3SS), variants and biosimilars thereof. The human antibodies of the invention are specifically directed at the EspB protein. The preset disclosure further provides compositions and uses of the disclosed antibodies in treatment and diagnosis of MDR pathogenic bacterial infections.
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