公开(公告)号：US20240353397A1

公开(公告)日：2024-10-24

申请号：US18683168

申请日：2022-08-11

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Irit GAT-VIKS ,  Eran BACHARACH ,  Gal YANKOVITZ ,  Ofir COHN ,  Naama PESHES-YALOZ

IPC: G01N33/50 ,  A61K31/473 ,  A61K31/496

CPC classification number: G01N33/5091 ,  A61K31/473 ,  A61K31/496 ,  G01N33/5023

Abstract: The present disclosure provides methods for evaluating the immunological state in a subject by determining the levels of resistance and/or disease tolerance of the subject, using specific signatory biomarkers for disease tolerance and resistance. The present disclosure further provides diagnostic compositions and kits, as well as therapeutic methods based on manipulating the expression of the disclosed resistance and/or disease-tolerance biomarkers to modulate the immunological state and disease outcome.