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    Compounds derived from lidocaine, pharmaceutical compositions, use and method of treatment, prevention or inhibition of disease
    6.
    发明授权
    Compounds derived from lidocaine, pharmaceutical compositions, use and method of treatment, prevention or inhibition of disease 失效
    衍生自利多卡因的化合物，药物组合物，用途和治疗方法，预防或抑制疾病

    公开(公告)号：US08163803B2

    公开(公告)日：2012-04-24

    申请号：US11570234

    申请日：2005-06-07

    申请人： Marco Aurélio Martins ,  Jorge Carlos Santos Da Costa ,  Núbia Boechat ,  Rodrigo de Azeredo Siqueira

    发明人： Marco Aurélio Martins ,  Jorge Carlos Santos Da Costa ,  Núbia Boechat ,  Rodrigo de Azeredo Siqueira

    IPC分类号： A61K31/167

    CPC分类号： C07C237/04 ,  C07D317/66 ,  C07D405/12 ,  C07D413/12

    摘要： The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these compounds or a salt of those as active principle and to the use of such compositions to treat, prevent or inhibit atopic diseases including asthma, rhinitis, allergic urticaria, chronic lung inflammation associated with eosinophilia, following the example of atopic asthma and chronic intestinal inflammation, as colitis for instance. The pharmaceutical composition may be available in spray form, solution, suspension, emulsion destinated to be applied by nebulization, or in any of the pharmaceutical available forms for oral or injectable use.

    摘要翻译： 本发明涉及利多卡因衍生化合物，其比利多卡因本身具有更少的麻醉活性，但具有比所述利多卡因更多的抗炎和解痉活性，以及​​具有至少一种这些化合物的药物组合物或作为活性成分的那些的盐 以及使用这样的组合物治疗，预防或抑制特应性疾病，包括哮喘，鼻炎，过敏性荨麻疹，伴随嗜酸性粒细胞增多的慢性肺部炎症，以特应性哮喘和慢性肠炎症为例，如结肠炎。 药物组合物可以以喷雾形式，溶液，悬浮液，预定为通过雾化施用的乳液，或任何药物可用形式用于口服或可注射使用。