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公开(公告)号：US20180008744A1
公开(公告)日：2018-01-11
申请号：US15269802
申请日：2016-09-19
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B2017/00884 , A61B2017/00893 , A61B2017/06185 , A61L17/06 , A61L2300/404 , A61L2300/414 , A61L2300/42 , A61L2300/45 , A61L2300/604 , A61L2300/64 , D06B1/10
摘要： Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
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2.发明授权Stem cell capture and immobilization coatings for medical devices and implants 有权用于医疗器械和植入物的干细胞捕获和固定涂层公开(公告)号：US08889168B2
公开(公告)日：2014-11-18
申请号：US12537409
申请日：2009-08-07
申请人： Richard H. Spedden , Judy Qiu , William Borch
发明人： Richard H. Spedden , Judy Qiu , William Borch
IPC分类号： A61L17/06 , A61L29/16 , A61L31/16 , A61L29/00 , A61L27/22 , A61L31/00 , A61L27/38 , A61L29/04 , A61L31/04 , A61K9/107 , A61K35/12
CPC分类号： A61L27/38 , A61L27/227 , A61L29/005 , A61L29/048 , A61L31/005 , A61L31/047
摘要： Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device.
摘要翻译： 本文描述了用于固定茎和其它前体细胞以及治疗价值的其它生物活性材料在医疗装置（例如骨，软骨，脊髓和牙齿植入物）的表面上的构造和方法。 本发明在将生物活性和治疗性材料并入医用植入物或其他介入装置中或在医疗植入物或其他介入装置上具有广泛的应用，其特征在于能够实时地利用医务人员从患者中提取的生物活性材料并随后重新引入和 固定在植入装置中。
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3.发明申请Therapeutic Material Delivery System for Tissue Voids and Cannulated Implants 审中-公开组织空洞和插管植入物的治疗物质输送系统公开(公告)号：US20130261597A1
公开(公告)日：2013-10-03
申请号：US13588110
申请日：2012-08-17
CPC分类号： A61M5/315 , A61B17/3468 , A61B17/3472 , A61B17/3478 , A61B17/864 , A61F2/28 , A61M5/19 , A61M5/3295
摘要： Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.
摘要翻译： 本文描述了具有对矫形外科医学领域特别适用的新型药物递送组件。 本文所述的装置和组件能够有效地应用和保留潜在的昂贵的治疗材料到非常特定的位置，特别是那些与骨骼和组织中的空隙有关的部位。 本发明的一个特别独特的方面涉及引入促进治疗材料在用于有益用途的目标应用领域中的保留的构建体，例如通过形成防止治疗材料渗出目标区域的近侧屏障。 另外，本发明提供了用于手术引入这种构建体的独特装置和方法。 本发明特别适用于引入干细胞和祖细胞，生物活性分子和骨骼支架材料以及骨空隙以及使用插管植入物，例如骨螺钉（也是手术螺钉）和引脚。 本发明还可用于递送癌症药物，抗微生物剂，骨水泥和其它治疗材料。
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4.发明授权公开(公告)号：US08876864B2
公开(公告)日：2014-11-04
申请号：US12489557
申请日：2009-06-23
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B2017/00884 , A61B2017/00893 , A61B2017/06185 , A61L17/06 , A61L2300/404 , A61L2300/414 , A61L2300/42 , A61L2300/45 , A61L2300/604 , A61L2300/64 , D06B1/10
摘要： Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
摘要翻译： 本文描述了用于固定生物活性分子，茎和其它前体细胞的材料和方法以及在外科缝线和其它组织支架装置中具有治疗价值的其它试剂。 广泛地将生物活性材料整合并结合到缝合结构，组织支架和医疗装置中，本发明在开发新颖的系统方面具有特别的用途，这些系统使得医疗人员能够执行手术和其他医疗程序来利用和随后重新引入提取的生物活性材料 从患者（或其同种异体等同物）到伤口或靶外科手术部位。
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5.发明授权Stem cell capture and immobilization coatings for medical devices and implants 有权用于医疗器械和植入物的干细胞捕获和固定涂层公开(公告)号：US08518431B2
公开(公告)日：2013-08-27
申请号：US13543059
申请日：2012-07-06
申请人： Richard H. Spedden , Judy Qiu , William Borch
发明人： Richard H. Spedden , Judy Qiu , William Borch
CPC分类号： A61L27/38 , A61L27/227 , A61L29/005 , A61L29/048 , A61L31/005 , A61L31/047
摘要： Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device.
摘要翻译： 本文描述了用于固定茎和其它前体细胞以及治疗价值的其它生物活性材料在医疗装置（例如骨，软骨，脊髓和牙齿植入物）的表面上的构造和方法。 本发明在将生物活性和治疗性材料并入医用植入物或其他介入装置中或在医疗植入物或其他介入装置上具有广泛的应用，其特征在于能够实时地利用医务人员从患者中提取的生物活性物质并随后重新引入和 固定在植入装置中。
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6.发明申请公开(公告)号：US20090318962A1
公开(公告)日：2009-12-24
申请号：US12489557
申请日：2009-06-23
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B2017/00884 , A61B2017/00893 , A61B2017/06185 , A61L17/06 , A61L2300/404 , A61L2300/414 , A61L2300/42 , A61L2300/45 , A61L2300/604 , A61L2300/64 , D06B1/10
摘要： Materials and Methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
摘要翻译： 本文描述了用于固定生物活性分子，茎和其它前体细胞的材料和方法以及在外科缝合线和其它组织支架装置中具有治疗价值的其它试剂。 广泛地将生物活性材料整合并结合到缝合结构，组织支架和医疗装置中，本发明在开发新颖的系统方面具有特别的用途，这些系统使得医疗人员能够执行手术和其他医疗程序来利用和随后重新引入提取的生物活性材料 从患者（或其同种异体等同物）到伤口或靶外科手术部位。
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7.发明授权公开(公告)号：US09446164B2
公开(公告)日：2016-09-20
申请号：US14518535
申请日：2014-10-20
CPC分类号： A61L17/005 , A61B17/06114 , A61B17/06166 , A61B2017/00884 , A61B2017/00893 , A61B2017/06185 , A61L17/06 , A61L2300/404 , A61L2300/414 , A61L2300/42 , A61L2300/45 , A61L2300/604 , A61L2300/64 , D06B1/10
摘要： Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
摘要翻译： 本文描述了用于固定生物活性分子，茎和其它前体细胞的材料和方法以及在外科缝线和其它组织支架装置中具有治疗价值的其它试剂。 广泛地将生物活性材料整合并结合到缝合结构，组织支架和医疗装置中，本发明在开发新颖的系统方面具有特别的用途，这些系统使得医疗人员能够执行手术和其他医疗程序来利用和随后重新引入提取的生物活性材料 从患者（或其同种异体等同物）到伤口或靶外科手术部位。
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8.发明授权Therapeutic material delivery system for tissue voids and cannulated implants 有权用于组织空隙和插管植入物的治疗材料输送系统公开(公告)号：US09433436B2
公开(公告)日：2016-09-06
申请号：US13935819
申请日：2013-07-05
CPC分类号： A61B17/3472 , A61B17/3468 , A61B17/3478 , A61B17/864 , A61F2/28 , A61M5/3295 , A61M31/00
摘要： Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.
摘要翻译： 本文描述了具有对矫形外科医学领域特别适用的新型药物递送组件。 本文所述的装置和组件能够有效地应用和保留潜在的昂贵的治疗材料到非常特定的位置，特别是那些与骨骼和组织中的空隙有关的部位。 本发明的一个特别独特的方面涉及引入促进治疗材料在用于有益用途的目标应用领域中的保留的构建体，例如通过形成防止治疗材料渗出目标区域的近侧屏障。 另外，本发明提供了用于手术引入这种构建体的独特装置和方法。 本发明特别适用于引入干细胞和祖细胞，生物活性分子和骨骼支架材料以及骨空隙以及使用插管植入物，例如骨螺钉（也是手术螺钉）和引脚。 本发明还可用于递送癌症药物，抗微生物剂，骨水泥和其它治疗材料。
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9.发明申请THERAPEUTIC MATERIAL DELIVERY SYSTEM FOR TISSUE VOIDS AND CANNULATED IMPLANTS 有权用于组织瓣和肛门植入物的治疗药物输送系统公开(公告)号：US20130296828A1
公开(公告)日：2013-11-07
申请号：US13935819
申请日：2013-07-05
CPC分类号： A61B17/3472 , A61B17/3468 , A61B17/3478 , A61B17/864 , A61F2/28 , A61M5/3295 , A61M31/00
摘要： Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.
摘要翻译： 本文描述了具有对矫形外科医学领域特别适用的新型药物递送组件。 本文所述的装置和组件能够有效地应用和保留潜在的昂贵的治疗材料到非常特定的位置，特别是那些与骨骼和组织中的空隙有关的部位。 本发明的一个特别独特的方面涉及引入促进治疗材料在用于有益用途的目标应用领域中的保留的构建体，例如通过形成防止治疗材料渗出目标区域的近侧屏障。 另外，本发明提供了用于手术引入这种构建体的独特装置和方法。 本发明特别适用于引入干细胞和祖细胞，生物活性分子和骨骼支架材料以及骨空隙以及使用插管植入物，例如骨螺钉（也是手术螺钉）和引脚。 本发明在递送癌症药物，抗微生物剂，骨水泥和其它治疗材料方面也具有有益的用途。
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10.发明授权Therapeutic material delivery system for tissue voids and cannulated implants 有权用于组织空隙和插管植入物的治疗材料输送系统公开(公告)号：US08317799B2
公开(公告)日：2012-11-27
申请号：US12414194
申请日：2009-03-30
CPC分类号： A61B17/3468 , A61B17/0057 , A61B17/3472 , A61B17/3478 , A61B17/864 , A61M31/00
摘要： Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.
摘要翻译： 本文描述了具有对矫形外科医学领域特别适用的新型药物递送组件。 本文所述的装置和组件能够有效地应用和保留潜在的昂贵的治疗材料到非常特定的位置，特别是那些与骨骼和组织中的空隙有关的部位。 本发明的一个特别独特的方面涉及引入促进治疗材料在用于有益用途的目标应用领域中的保留的构建体，例如通过形成防止治疗材料渗出目标区域的近侧屏障。 另外，本发明提供了用于手术引入这种构建体的独特装置和方法。 本发明特别适用于引入干细胞和祖细胞，生物活性分子和骨骼支架材料以及骨空隙以及使用插管植入物，例如骨螺钉（也是手术螺钉）和引脚。 本发明还可用于递送癌症药物，抗微生物剂，骨水泥和其它治疗材料。
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