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公开(公告)号：US09273118B2
公开(公告)日：2016-03-01
申请号：US13383832
申请日：2010-07-15
Applicant: Tim Beaumont , Hergen Spits , Mark J. Kwakkenbos , Adrianus Q. Bakker
Inventor： Tim Beaumont , Hergen Spits , Mark J. Kwakkenbos , Adrianus Q. Bakker
CPC classification number: C07K16/1027 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
Abstract: The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.
Abstract translation: 本发明提供用于调节抗体产生浆细胞样B细胞中体细胞超突变的发生的方法和方法。
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公开(公告)号：US20220064323A1
公开(公告)日：2022-03-03
申请号：US17476650
申请日：2021-09-16
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen SPITS , Paula Maria Wilhelmina VAN HELDEN , Remko SCHOTTE , Wouter POS , Christien FATMAWATI , Danïel Michiel GO , Koen WAGNER , Julien Christian VILLAUDY
IPC: C07K16/28 , A61P35/00 , C07K14/705 , G01N33/574
Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.
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公开(公告)号：US10690658B2
公开(公告)日：2020-06-23
申请号：US15316419
申请日：2015-06-05
Applicant: AIMM Therapeutics B.V. , Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis
Inventor： Carsten Linnemann , Laura Bies , Marit Martha van Buuren , Antonius Nicolaas Maria Schumacher , Hergen Spits , Remko Schotte
IPC: C12N5/00 , C12N5/02 , G01N33/50 , A61K39/00 , G01N33/569
Abstract: The invention provides improved screening methods for testing T cell recognition of T cell epitopes.
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公开(公告)号：US09969795B2
公开(公告)日：2018-05-15
申请号：US14956919
申请日：2015-12-02
Applicant: AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Hergen Spits , Adrianus Quirinus Bakker , Koen Wagner
CPC classification number: C07K16/1018 , C07K14/4703 , C07K14/4747 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/92
Abstract: The invention provides means and methods for producing high-affinity antibodies against an antigen of interest, usually stable B-cell cultures.
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公开(公告)号：US09688745B2
公开(公告)日：2017-06-27
申请号：US14981643
申请日：2015-12-28
Applicant: Genentech, Inc. , AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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Patent Agency Ranking
公开(公告)号：US09266943B2
公开(公告)日：2016-02-23
申请号：US14103715
申请日：2013-12-11
Applicant: Genentech, Inc. , AIMM THERAPEUTICS B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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公开(公告)号：US10774308B2
公开(公告)日：2020-09-15
申请号：US16114483
申请日：2018-08-28
Inventor： Hergen Spits
IPC: A61K38/00 , C07K16/00 , C12N5/18 , C12N5/0781
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US20190023803A1
公开(公告)日：2019-01-24
申请号：US16068742
申请日：2017-01-06
Applicant: AIMM Therapeutics B.V.
Inventor： Hergen SPITS , Paula Maria Wilhelmina VAN HELDEN , Remko SCHOTTE , Wouter POS , Christien FATMAWATI , Danïel Michiel GO , Koen WAGNER , Julien Christian VILLAUDY
IPC: C07K16/28 , C07K14/705 , G01N33/574 , A61P35/00
Abstract: The present invention provides novel binding compounds and therapeutic applications thereof.
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公开(公告)号：US09718876B2
公开(公告)日：2017-08-01
申请号：US14359291
申请日：2012-11-16
Applicant: AIMM Therapeutics B.V.
Inventor： Tim Beaumont , Etsuko Yasuda
IPC: C07K16/10 , G01N33/569 , A61K39/00
CPC classification number: C07K16/1027 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/76 , G01N33/56983 , G01N2333/135
Abstract: The disclosure relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the RSV G protein. Antibodies specific for the RSV G protein are particularly suitable for counteracting RSV and symptoms, such as inflammation, resulting from an RSV infection. The disclosure further relates to the use of such RSV G-specific antibodies for diagnosis of an RSV infection and as a medicament and/or prophylactic agent for, at least in part, treating or alleviating symptoms of a Respiratory Syncytial Virus infection and/or a Respiratory Syncytial Virus related disorder.
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公开(公告)号：US09458228B2
公开(公告)日：2016-10-04
申请号：US14728826
申请日：2015-06-02
Applicant: Genentech, Inc. , AIMM Therapeutics B.V.
Inventor： Tim Beaumont , Mark Jeroen Kwakkenbos , Eric J. Brown , John Hiroshi Morisaki , Wouter L. W. Hazenbos , Sanjeev Mariathasan , Kimberly Kajihara , Yi Xia
IPC: C07K16/12
CPC classification number: G01N33/5091 , C07K16/1271 , C07K16/1278 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N33/6893 , G01N2469/10 , G01N2800/26
Abstract: The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals.
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