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1.发明授权Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer 有权用于治疗前列腺癌或诱导针对前列腺癌的体液免疫应答的方法和组合物公开(公告)号：US08840881B2
公开(公告)日：2014-09-23
申请号：US12546399
申请日：2009-08-24
CPC分类号： A61K39/0011 , A61K35/13 , A61K38/193 , A61K48/00 , A61K2035/122 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522 , A61K2039/575
摘要： The present invention relates to prostate cancer markers, compositions comprising such markers, and methods of using such markers to induce or increase an immune response against prostate cancer. An immune response against the markers correlates with an immune response, in particular a humoral immune response, against prostate cancer cells which immune response is preferably associated with prophylaxis of prostate cancer, treatment of prostate cancer, and/or amelioration of at least one symptom associated with prostate cancer.
摘要翻译： 本发明涉及前列腺癌标志物，包含这些标记物的组合物，以及使用这些标记物诱导或增加针对前列腺癌的免疫应答的方法。 针对标记的免疫应答与针对前列腺癌细胞的免疫应答，特别是体液免疫应答相关，所述免疫应答优选与前列腺癌的预防，前列腺癌的治疗和/或改善相关的至少一种症状有关 与前列腺癌。
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公开(公告)号：US09433204B2
公开(公告)日：2016-09-06
申请号：US13040685
申请日：2011-03-04
申请人： David Frey , Andy Lin , Gautum Banik
发明人： David Frey , Andy Lin , Gautum Banik
IPC分类号： A61K35/12 , A01N1/02 , A61K35/407 , A61K48/00 , A61K39/00
CPC分类号： A01N1/0221 , A01N1/02 , A61K35/12 , A61K35/407 , A61K38/193 , A61K39/0011 , A61K39/39 , A61K47/20 , A61K47/36 , A61K47/42 , A61K48/00 , A61K2039/5152 , A61K2039/55522 , Y10T436/108331
摘要： This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO or glycerol.
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公开(公告)号：US09848598B2
公开(公告)日：2017-12-26
申请号：US15236343
申请日：2016-08-12
申请人： ADURO GVAX INC.
发明人： David Frey , Andy Lin , Gautum Banik
IPC分类号： C12N5/00 , A01N1/02 , A61K35/407 , A61K38/19 , A61K39/39 , A61K47/20 , A61K47/36 , A61K47/42 , A61K35/12 , A61K48/00 , A61K39/00
CPC分类号： A01N1/0221 , A01N1/02 , A61K35/12 , A61K35/407 , A61K38/193 , A61K39/0011 , A61K39/39 , A61K47/20 , A61K47/36 , A61K47/42 , A61K48/00 , A61K2039/5152 , A61K2039/55522 , Y10T436/108331
摘要： This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO or glycerol.
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4.发明授权PS-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof 有权PS-1抗体与细胞因子分泌细胞的组合及其使用方法公开(公告)号：US08580247B2
公开(公告)日：2013-11-12
申请号：US13619699
申请日：2012-09-14
申请人： Betty Li , Karin Jooss , Alan J. Korman
发明人： Betty Li , Karin Jooss , Alan J. Korman
IPC分类号： A61K39/00
CPC分类号： A61K39/39558 , A61K38/193 , A61K39/0011 , A61K39/3955 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , A61K2300/00
摘要： The present invention relates to a method of enhancing the anti-tumor response in a mammal. More particularly, the invention is concerned with combinations comprising a cytokine-secreting cell and an anti-PD-1 antibody, and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer.
摘要翻译： 本发明涉及增强哺乳动物抗肿瘤反应的方法。 更具体地，本发明涉及包含细胞因子分泌细胞和抗PD-1抗体的组合以及用于增加患有癌症的患者中对肿瘤细胞的免疫应答的组合的方法。
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公开(公告)号：US09669081B2
公开(公告)日：2017-06-06
申请号：US14491949
申请日：2014-09-19
申请人： ADURO GVAX INC.
CPC分类号： A61K39/0011 , A61K35/13 , A61K38/193 , A61K48/00 , A61K2035/122 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522 , A61K2039/575
摘要： The present invention relates to prostate cancer markers, compositions comprising such markers, and methods of using such markers to induce or increase an immune response against prostate cancer. An immune response against the markers correlates with an immune response, in particular a humoral immune response, against prostate cancer cells which immune response is preferably associated with prophylaxis of prostate cancer, treatment of prostate cancer, and/or amelioration of at least one symptom associated with prostate cancer.
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6.发明申请PD-1 ANTIBODIES IN COMBINATION WITH A CYTOKINE-SECRETING CELL AND METHODS OF USE THEREOF 审中-公开与细胞因子分泌细胞组合的PD-1抗体及其使用方法公开(公告)号：US20140271684A1
公开(公告)日：2014-09-18
申请号：US14078042
申请日：2013-11-12
申请人： Medarex, Inc. , ADURO GVAX INC.
发明人： Betty LI , Karin JOOSS , Alan J. KORMAN
IPC分类号： A61K39/395 , A61K38/19
CPC分类号： A61K39/39558 , A61K38/193 , A61K39/0011 , A61K39/3955 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , A61K2300/00
摘要： The present invention relates to a method of enhancing the anti-tumor response in a mammal. More particularly, the invention is concerned with combinations comprising a cytokine-secreting cell and an anti-PD-1 antibody, and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer.
摘要翻译： 本发明涉及增强哺乳动物抗肿瘤反应的方法。 更具体地，本发明涉及包含细胞因子分泌细胞和抗PD-1抗体的组合以及用于增加患有癌症的患者中对肿瘤细胞的免疫应答的组合的方法。
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