AraC in combination with a cytokine-secreting cell and methods of use thereof
    6.
    发明申请
    AraC in combination with a cytokine-secreting cell and methods of use thereof 审中-公开
    AraC与细胞因子分泌细胞的组合及其使用方法

    公开(公告)号:US20080267935A1

    公开(公告)日:2008-10-30

    申请号:US12080719

    申请日:2008-04-04

    摘要: The present invention provides improved method of cancer therapy in a mammal. More particularly, the invention is concerned with systems comprising cytosine arabinoside (AraC) and a cytokine-expressing cancer immunotherapy composition and methods of administering the combination to cancer patients in order to generate an immune response against the cancer and provide treatment with therapeutic efficacy that is an improvement relative to administration of AraC or the cytokine-expressing cancer immunotherapy composition alone as a monotherapy.

    摘要翻译: 本发明提供了哺乳动物癌症治疗的改进方法。 更具体地,本发明涉及包含胞嘧啶阿拉伯糖苷(AraC)和表达细胞因子的癌症免疫治疗组合物的系统以及向癌症患者施用组合的方法,以产生针对癌症的免疫应答,并提供具有治疗功效的治疗 相对于单独使用AraC或单独使用细胞因子的癌症免疫治疗组合物而言,其改善。

    Cytokine-expressing cancer immunotherapy combinations
    10.
    发明申请
    Cytokine-expressing cancer immunotherapy combinations 审中-公开
    细胞因子表达的癌症免疫治疗组合

    公开(公告)号:US20070231298A1

    公开(公告)日:2007-10-04

    申请号:US11728660

    申请日:2007-03-27

    IPC分类号: A61K38/20 A61N5/00 A61K31/517

    摘要: The present invention in all of its associated aspects provides improved methods and compositions for treating cancer in a mammal based on the sequential administration of the combination of a cytokine-expressing cancer immunotherapy composition and at least one tyrosine kinase inhibitor, wherein administration of the combination results in enhanced therapeutic efficacy relative to administration of the cytokine-expressing cancer immunotherapy composition or at least one tyrosine kinase inhibitor as a monotherapy.

    摘要翻译: 本发明在其所有相关方面提供了改进的用于在哺乳动物中治疗癌症的方法和组合物,其基于表达细胞因子的癌症免疫治疗组合物与至少一种酪氨酸激酶抑制剂的组合的顺次施用,其中施用组合结果 相对于施用表达细胞因子的癌症免疫治疗组合物或至少一种酪氨酸激酶抑制剂作为单一疗法而言,具有增强的治疗功效。