公开(公告)号：US20180333485A1

公开(公告)日：2018-11-22

申请号：US15974982

申请日：2018-05-09

申请人： The Trustees of the University of Pennsylvania

发明人： David Weiner ,  Matthew P. Morrow ,  Jian Yan

IPC分类号： A61K39/39 ,  A61K38/20 ,  A61K39/00 ,  A61K41/00 ,  A61K39/29 ,  C12N7/00 ,  C07K14/54 ,  A61K39/245

CPC分类号： A61K39/39 ,  A61K38/20 ,  A61K38/208 ,  A61K38/2086 ,  A61K39/0005 ,  A61K39/0011 ,  A61K39/245 ,  A61K39/292 ,  A61K41/00 ,  A61K2039/525 ,  A61K2039/53 ,  A61K2039/55538 ,  C07K14/5434 ,  C12N7/00 ,  C12N2510/00 ,  C12N2710/16034 ,  C12N2730/10134 ,  C12N2730/10171

摘要： Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.

公开(公告)号：US10125174B2

公开(公告)日：2018-11-13

申请号：US15618740

申请日：2017-06-09

申请人： GenVec, Inc.

发明人： Lisa Wei ,  Douglas E. Brough ,  Christopher Lazarski

IPC分类号： C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/245 ,  A61K39/00

摘要： Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.

公开(公告)号：US20180312547A1

公开(公告)日：2018-11-01

申请号：US16030663

申请日：2018-07-09

申请人： Deutsches Krebsforschungszentrum

发明人： Henri-Jacques Delecluse ,  Regina Feederle ,  Emmalene Bartlett

IPC分类号： C07K14/005 ,  C07K16/28 ,  A61K39/245 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/55516 ,  A61K2039/572 ,  A61K2039/585 ,  A61K2039/6056 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/569 ,  C07K2319/33 ,  C12N7/00 ,  C12N2710/16222 ,  C12N2710/16234

摘要： The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22, CD19, CD20, and CD21, and b) an immunogenic peptide comprising at least one T-cell epitope for use in vaccination of a subject against B-cell hyperproliferation or for use in the modulation of the immune response in a subject. The present invention further relates to a polynucleotide and a vector encoding said polypeptide and a host cell comprising the same. It also relates to a method for the stimulation of antigen-specific T-cells, comprising a) contacting antigen presenting cells (APC) with a polypeptide, the polynucleotide, or the vector of the invention, b) contacting said APC with T-cells, and c) thereby stimulating antigen-specific T-cells specific for said at least one T-cell epitope; to a method for immunizing a subject against B-cell hyperproliferation, to a method for immunizing a subject against an infectious agent, and to a method for inducing tolerance in a subject.

公开(公告)号：US20180303931A1

公开(公告)日：2018-10-25

申请号：US15971025

申请日：2018-05-04

申请人： The Henry M. Jackson foundation for the Advancement of Military Medicine, Inc.

发明人： James J. MOND ,  Clifford M. SNAPPER ,  Xinle CUI

IPC分类号： A61K39/245 ,  A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  A61K39/00

摘要： The present disclosure provides fusion proteins that incorporate unique mechanisms for multimerizing antigens to enhance their immunogenicity. The fusion proteins comprise at least two antigens, or other vaccine related proteins, separated by a linker sequence and an oligomerization domain. When expressed, the fusion protein forms a muKimeric protein complex, This approach can be used to muHimeri?.e a single antigen/protein or to create multimers comprising two or more different antigens/proteins. Also provided are nucleic acids encoding the fusion proteins. Yet another aspect is directed to methods of inducing or suppressing an immune response in a subject by administering to the subject a vaccine composition comprising a fusion protein or nucleic acid encoding the fusion protein, optionally without using an adjuvant.

公开(公告)号：US20180303929A1

公开(公告)日：2018-10-25

申请号：US15767618

申请日：2016-10-21

申请人： Moderna TX, Inc.

发明人： Giuseppe Ciaramella ,  Shinu John ,  Andrew J. Bett ,  Danilo R. Casimiro

IPC分类号： A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61P31/22

CPC分类号： A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/55555 ,  A61P31/22 ,  C12N2710/16634 ,  Y02A50/39

摘要： The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20180271975A1

公开(公告)日：2018-09-27

申请号：US16006526

申请日：2018-06-12

申请人： ModernaTX, Inc.

发明人： Giuseppe Ciaramella ,  Shinu John ,  Kambiz Mousavi

IPC分类号： A61K39/245 ,  A61K31/7115 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  A61K31/7105 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/005 ,  C07K2319/02 ,  C12N7/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16151 ,  C12N2710/16171

摘要： The disclosure describes HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US10076568B2

公开(公告)日：2018-09-18

申请号：US15455495

申请日：2017-03-10

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

发明人： William Jacobs, Jr. ,  Pablo A. Gonzalez Munoz ,  Betsy Herold ,  Christopher Petro

IPC分类号： A61K39/245 ,  C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/572 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16643 ,  C12N2710/16662 ,  C12N2710/16671

摘要： Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.

公开(公告)号：US20180258396A1

公开(公告)日：2018-09-13

申请号：US15759723

申请日：2016-09-14

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Jeffrey MILLER ,  Frank CICHOCKI ,  Yenan BRYCESON ,  Heinrich SCHLUMS

IPC分类号： C12N5/0783 ,  A61K39/245 ,  A61K35/17 ,  A61K45/06 ,  A61P35/00 ,  C12N7/00

CPC分类号： C12N5/0646 ,  A61K35/17 ,  A61K39/245 ,  A61K45/06 ,  A61K2039/572 ,  A61K2039/585 ,  A61P35/00 ,  C12N7/00 ,  C12N2501/04 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/42 ,  C12N2501/599 ,  C12N2502/1121 ,  C12N2502/1157 ,  C12N2502/1352 ,  C12N2710/16134

摘要： This disclosure describes an adaptive NK cell, an isolated population of adaptive Natural Killer (NK) cells, a composition including an adaptive NK cell, and methods for producing, preparing, and using an adaptive NK cell or an isolated population or composition including an adaptive NK cell. The adaptive NK cells may be used to treat a viral infection or a tumor.

公开(公告)号：US10016494B2

公开(公告)日：2018-07-10

申请号：US15116968

申请日：2015-02-06

申请人： VALORISATION-HSJ, LIMITED PARTNERSHIP ,  VALORISATION-RECHERCHE, LIMITED PARTNERSHIP

发明人： Caroline Alfieri ,  Jerome Tanner ,  Jing Hu ,  Jurgen Sygusch ,  Mathieu Coinçon

IPC分类号： A61K39/245 ,  C07K14/05 ,  A61K39/12 ,  G01N33/68 ,  G01N33/569 ,  C07K16/08

CPC分类号： A61K39/12 ,  C07K16/085 ,  C07K2317/24 ,  C07K2317/76 ,  C12N2710/16222 ,  C12N2710/16234 ,  G01N33/56994 ,  G01N33/6854 ,  G01N2469/20

摘要： The present invention relates to a peptide comprising (A) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence PDDRTLQ (SEQ ID NO:1); and (ii) a second domain covalently linked to the first domain and comprising an amino acid sequence having at least 60% sequence similarity with the sequence QNPVYLIPETVPYIKWDN (SEQ ID NO:2) or (B) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence GSAKPGNGSYF (SEQ ID NO: 41); and (ii) a second domain covalently linked to the first domain, said second domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence SVKTEMLGNEID (SEQ ID NO: 42), wherein the peptide binds to monoclonal antibody clone 72A1. This peptide may be useful for inducing the production of neutralizing antibodies against a gp350-expressing herpesvirus, such as Epstein-Barr virus (EBV), for example for immunizing or vaccinating an animal against a gp350-expressing herpesvirus, as well as for detecting the presence or absence neutralizing anti-gp350-expressing herpesvirus antibodies in a sample.

公开(公告)号：US20180187164A1

公开(公告)日：2018-07-05

申请号：US15740824

申请日：2016-06-29

申请人： CEVA SANTE ANIMALE

发明人： SAEKI YUKARI ,  SHUJI SAITOH

IPC分类号： C12N7/00 ,  A61K39/245

CPC分类号： C12N7/00 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/54 ,  C12N7/04 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16361 ,  C12N2710/16362

摘要： The present invention relates to DEV and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.