公开(公告)号：US20070142873A1

公开(公告)日：2007-06-21

申请号：US11469029

申请日：2006-08-31

Applicant: Rosana Esteller ,  Javier Echauz ,  Brian Litt ,  George Vachtsevanos

Inventor： Rosana Esteller ,  Javier Echauz ,  Brian Litt ,  George Vachtsevanos

IPC: A61N1/00

CPC classification number: A61B5/076 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/4094 ,  A61B5/486 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  A61N1/08 ,  A61N1/36082 ,  G06F19/00 ,  G06K9/00523

Abstract: An adaptive method and apparatus for forecasting and controlling neurological abnormalities in humans such as seizures or other brain disturbances. The system is based on a multi-level control strategy. Using as inputs one or more types of physiological measures such as brain electrical, chemical or magnetic activity, heart rate, pupil dilation, eye movement, temperature, chemical concentration of certain substances, a feature set is selected off-line from a pre-programmed feature library contained in a high level controller within a supervisory control architecture. This high level controller stores the feature library within a notebook or external PC. The supervisory control also contains a knowledge base that is continuously updated at discrete steps with the feedback information coming from an implantable device where the selected feature set (feature vector) is implemented. This high level controller also establishes the initial system settings (off-line) and subsequent settings (on-line) or tunings through an outer control loop by an intelligent procedure that incorporates knowledge as it arises. The subsequent adaptive settings for the system are determined in conjunction with a low-level controller that resides within the implantable device. The device has the capabilities of forecasting brain disturbances, controlling the disturbances, or both. Forecasting is achieved by indicating the probability of an oncoming seizure within one or more time frames, which is accomplished through an inner-loop control law and a feedback necessary to prevent or control the neurological event by either electrical, chemical, cognitive, sensory, and/or magnetic stimulation.

Abstract translation: 一种用于预测和控制人类神经系统异常的自适应方法和装置，例如癫痫发作或其他大脑紊乱。 该系统基于多层次的控制策略。 使用作为输入的一种或多种类型的生理测量，例如脑电，化学或磁性活动，心率，瞳孔扩张，眼睛运动，温度，某些物质的化学浓度，特征集是从预先编程的 特征库包含在监控控制架构中的高级别控制器中。 该高级控制器将功能库存储在笔记本电脑或外部PC中。 监督控制还包含一个知识库，它以离散的步骤连续更新，反馈信息来自可实现选定特征集（特征向量）的可植入装置。 该高级控制器还通过包含知识的智能过程，通过外部控制环路建立初始系统设置（离线）和后续设置（在线）或调谐。 系统的后续自适应设置与驻留在可植入装置内的低级别控制器一起确定。 该装置具有预测大脑紊乱，控制干扰或两者兼有的能力。 通过指示在一个或多个时间范围内即将到来的癫痫发作的概率来实现预测，该概率通过内环控制规律和通过电学，化学，认知，感觉和/或功能来预防或控制神经学事件所必需的反馈 /或磁刺激。

公开(公告)号：US20070123350A1

公开(公告)日：2007-05-31

申请号：US10596862

申请日：2004-11-29

Applicant: Staffan Soderlund

Inventor： Staffan Soderlund

IPC: A63F9/24

CPC classification number: A63F7/041 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/16 ,  A63F7/0017 ,  A63F13/10 ,  A63F2007/405 ,  A63F2009/0007 ,  A63F2009/243 ,  A63F2009/2488 ,  A63F2300/1012

Abstract: The method is for playing a game by providing each player with a sensor for measuring brain wave frequencies of the players. The player moves a unit on a playing area in an x-direction toward the player when the brain wave frequency of the player is at a first frequency and the brain wave frequency of the player is at a second frequency wherein the first frequency is lower than the second frequency. The player moves the unit in a y-direction perpendicular to the x-direction when the brain wave frequency of the player is at a third frequency and the brain wave frequency of the player is at a fourth frequency wherein the third frequency is greater than the fourth frequency.

Abstract translation: 该方法是通过为每个玩家提供用于测量玩家的脑波频率的传感器来玩游戏。 当玩家的脑波频率处于第一频率并且玩家的脑电波频率处于第一频率低于第一频率的第二频率时，玩家在玩游戏区域中向x方向移动单元朝向玩家 第二个频率。 当玩家的脑波频率处于第三频率并且玩家的脑波频率处于第四频率时，玩家在垂直于x方向的y方向上移动单位，其中第三频率大于 第四频。

公开(公告)号：US20060167722A1

公开(公告)日：2006-07-27

申请号：US11044445

申请日：2005-01-27

Applicant: Michel MRF Struys ,  Tom Smet ,  Steven Shafer

Inventor： Michel MRF Struys ,  Tom Smet ,  Steven Shafer

IPC: A61B5/00 ,  A61K9/22

CPC classification number: A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0482 ,  A61B5/4821 ,  A61B5/4839 ,  G06F19/00 ,  G06Q50/24

Abstract: The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, in accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patient. The patient response profile is a graphical, tabular or analytical expression of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication delivery unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.

Abstract translation: 本发明提供了用于确定和维持患者中药物浓度水平的系统和方法，其足以实现并保持对该患者的期望效果。 一般而言，根据本发明的一个实施方案，药物输送控制器使用患者反应特征来确定将达到对患者所期望的效果的患者中的药物浓度。 患者反应曲线是药物浓度与药物在特定浓度下的作用之间关系的图形，表格或分析表达。 使用该信息，药物输送控制器向药物输送单元（例如输液泵或吸入装置）提供指令，以将药物递送到患者的速率将达到药物的期望浓度水平 患者。

公开(公告)号：US07081085B2

公开(公告)日：2006-07-25

申请号：US10276018

申请日：2002-02-05

Applicant: Erik Viirre ,  Jaime A. Pineda ,  F. Richard Moore

Inventor： Erik Viirre ,  Jaime A. Pineda ,  F. Richard Moore

IPC: A61M21/00

CPC classification number: A61B5/0482 ,  A61B5/04845 ,  A61F11/00

Abstract: An automated method for treating tinnitus by habituation through use of neurological feedback, comprising the steps of connecting a subject through a set of attached headphones to an electronic sound player that is connected to a PC workstation presenting sound examples by software to the subject who can refine them by manipulating a series of controllers on the player, making an electronic recording of the sound in a digital music format, storing the recording in the computer, transferring a copy of the electronic sound file to the subject's electronic music player, generating an EEC signature of the subject's brain activity in response to the presented sound, sound using the customized sound to stimulate the auditory system while the brain activity is recorded, wherein the computer continuously monitors for the feedback signatures and drives the sound stimuli appropriately.

公开(公告)号：US20060047324A1

公开(公告)日：2006-03-02

申请号：US10522933

申请日：2003-07-05

Applicant: Peter Tass

Inventor： Peter Tass

IPC: A61N1/32

CPC classification number: A61B5/4064 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/04842 ,  A61B5/04845 ,  A61M21/00 ,  A61M2230/10

Abstract: The invention relates to a device for controlled modulation of physiological and pathological neuronal rhythmic activity in the brain by means of sensory stimulation, which is capable of diagnostically ascertaining functional disorders in the brain and of alleviating or eliminating the symptoms of a functional disruption. According to the invention, the device comprises a control unit (4), a stimulator (1) and at least one means for detecting brain activity, said means being connected to the control unit (1).

Abstract translation: 本发明涉及用于通过感觉刺激来控制调节脑中生理和病理学神经元节律活动的装置，其能够诊断上确定大脑中的功能障碍以及减轻或消除功能性破坏的症状。 根据本发明，该装置包括控制单元（4），刺激器（1）和至少一个用于检测大脑活动的装置，所述装置连接到控制单元（1）。

公开(公告)号：US20050203366A1

公开(公告)日：2005-09-15

申请号：US10798919

申请日：2004-03-12

Applicant: John Donoghue ,  Mijail Serruya ,  J. Flaherty ,  Brian Hatt ,  Jon Joseph

Inventor： John Donoghue ,  Mijail Serruya ,  J. Flaherty ,  Brian Hatt ,  Jon Joseph

IPC: A61B5/00 ,  A61B5/03 ,  A61B5/04 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/0482 ,  A61B5/0488 ,  A61B5/055 ,  A61B5/11 ,  A61B7/00 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61B5/7282 ,  A61B5/0059 ,  A61B5/01 ,  A61B5/031 ,  A61B5/04002 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/055 ,  A61B5/11 ,  A61B5/4094 ,  A61B5/4839 ,  A61B5/6814 ,  A61B5/7239 ,  A61B5/7275 ,  A61B7/001 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/36135 ,  A61N1/37241 ,  G16H40/67 ,  G16H50/20

Abstract: Systems and methods for detecting, monitoring, and/or treating neurological events based on, for example, electrical signals generated from the patient's body are disclosed. Various embodiments of the invention include a system for predicting occurrence of a neurological event in a patient's body. The system may include an implant configured to be placed in the body and detect signals indicative of an activity that precedes the neurological event, and a processing unit configured to process the detected signals so as to predict the neurological event prior to the occurrence.

Abstract translation: 公开了用于基于例如从患者身体产生的电信号来检测，监测和/或治疗神经病事件的系统和方法。 本发明的各种实施例包括用于预测患者体内神经系统事件发生的系统。 该系统可以包括被配置为放置在身体中并且检测指示在神经事件之前的活动的信号的植入物;以及处理单元，被配置为处理检测到的信号，以便在发生之前预测神经系统事件。

公开(公告)号：US06855112B2

公开(公告)日：2005-02-15

申请号：US10074617

申请日：2002-02-12

Applicant: Shang Ren Henry Kao ,  Ching Hui Goan

Inventor： Shang Ren Henry Kao ,  Ching Hui Goan

IPC: A61B5/00 ,  A61B5/0482 ,  A61B5/16

CPC classification number: A61B5/0482 ,  A61B5/16 ,  A61B5/4854 ,  A61B5/486

Abstract: The present invention relates to a method of and a system for treating a health condition of a user. The method includes determining a sensory signal for use to treat the user's health condition, measuring the change to the sensory signal while the user is engaging in an activity, and using the sensory signal change to regulate the user's activity to thereby treat the user's health condition. The system has a sensor device for measuring a sensory signal of the user while the user is engaging in an activity and a display device receiving the sensory signal measured by the sensor device and displaying the sensory signal. The change to the sensory signal is used to regulate the user's activity to thereby treat the user's health condition.

Abstract translation: 本发明涉及用于治疗使用者健康状况的方法和系统。 该方法包括确定用于治疗用户的健康状况的感觉信号，在用户参与活动时测量感觉信号的变化，以及使用感觉信号改变来调节用户的活动从而治疗用户的健康状况 。 该系统具有用于在用户参与活动时测量用户的感觉信号的传感器装置和接收由传感器装置测量的感觉信号并显示感觉信号的显示装置。 感官信号的改变用于调节用户的活动，从而治疗用户的健康状况。

公开(公告)号：US20040073129A1

公开(公告)日：2004-04-15

申请号：US10272514

申请日：2002-10-15

Applicant: SSI Corporation

Inventor： Samuel J. Caldwell ,  Taka-aki Tanaka ,  Yoku Ogawa

IPC: A61B005/04

CPC classification number: A61B5/0478 ,  A61B5/0482 ,  A61B5/6814 ,  A61B5/6816

Abstract: A data acquisition unit for an EEG system includes pliant electrodes and/or a wireless transmitter that permit use of the EEG system without electrolyte gels or solutions and/or connecting wires. The electrodes can use a conductive fabric or a conductive rubber material that is dry or damp and mounted in a rigid structure that plugs into a socket on a headset. A feedback unit in the EEG system, which receives and processes the data from data acquisition unit, can be a high power, high performance processing system that implements complex feedback presentations and control functions based on analysis of the EEG data. In one embodiment, the feedback system controls a presentation player and adjusts a playback rate according to the sensed brain activity or synchrony between left and right brain activity. A PWM signal can control the time scale of the presentation.

Abstract translation: 用于EEG系统的数据采集单元包括柔性电极和/或无线发射器，其允许使用没有电解质凝胶或溶液和/或连接线的EEG系统。 电极可以使用干燥或潮湿的导电织物或导电橡胶材料，并且安装在刚性结构中，其插入耳机上的插座中。 EEG系统中的反馈单元，其从数据采集单元接收和处理数据，可以是基于EEG数据分析实现复杂反馈呈现和控制功能的高功率，高性能处理系统。 在一个实施例中，反馈系统控制呈现播放器并且根据感测的大脑活动或左脑和右脑活动之间的同步来调整播放速率。 PWM信号可以控制演示的时间尺度。

公开(公告)号：US20030171688A1

公开(公告)日：2003-09-11

申请号：US10199346

申请日：2002-07-19

Inventor： Jae Sup Yoo ,  Jae Chun Yoo

IPC: A61B005/04

CPC classification number: A61B5/0482 ,  A61B5/7405

Abstract: A mind controller is disclosed. The mind controller can induce a user's brain waves into an alpha wave state or a theta wave state by sensing and analyzing human brain waves and then transmitting a mind control audio message suitable for the analyzed human brain waves to the user, so that the user can improve mental concentration power or memory for himself/herself. The mind controller for activating brain waves generated from the user's brain, includes: an EEG(Electroencephalogram) sensor for sensing frequency band corresponding to alpha waves and theta waves from the brain waves generated from the user's brain; an MCU(Memory Control Unit) for analyzing whether the brain waves sensed by the EEG sensor are alpha waves or theta waves through a built-in program of a brain wave analysis program pack and controlling output of a message, which corresponds to the alpha waves or the theta waves, out of mind control audio messages of an MP3 pack; an audio decoder for demodulating signal converted into data in the MP3 pack by control signal output from the MCU; a D/A converter for receiving signal provided from the audio decoder and converting the signal into analog audio signal; and audio output means for converting and providing the analog audio signal into sound.

Abstract translation: 公开了心智控制器。 心理控制器可以通过感测和分析人脑电波，然后将适合于分析的人类脑电波的心理控制音频消息传送给用户，从而将用户的脑电波诱导成α波状态或θ波状态，从而用户可以 提高自己的精神集中力或记忆力。 用于激活从用户脑部产生的脑波的思维控制器包括：用于感测来自用户脑部产生的脑波的α波和θ波的频带的EEG（脑电图）传感器; 用于分析由EEG传感器感测的脑电波是通过脑波分析程序包的内置程序并控制对应于α波的消息的输出的MCU（存储器控制单元） 或θ波，不理会控制MP3包的音频消息; 音频解码器，用于通过从MCU输出的控制信号来解调转换成MP3包中的数据的信号; D / A转换器，用于接收从音频解码器提供的信号并将该信号转换为模拟音频信号; 以及用于将模拟音频信号转换并提供给声音的音频输出装置。

公开(公告)号：US06507754B2

公开(公告)日：2003-01-14

申请号：US10046696

申请日：2002-01-17

Applicant: Michel Le Van Quyen ,  Jacques Martinerie ,  Francisco Varela ,  Michel Baulac

Inventor： Michel Le Van Quyen ,  Jacques Martinerie ,  Francisco Varela ,  Michel Baulac

IPC: A61B50476

CPC classification number: A61B5/4094 ,  A61B5/0476 ,  A61B5/0482 ,  Y10S128/92

Abstract: The invention concerns a device and a method for the detection of changes in dynamic properties of electrical brain activity to characterize and to differentiate between physiological and pathological conditions, or to anticipate epileptic seizures.

Abstract translation: 本发明涉及一种用于检测电脑活动的动态特性的变化以表征和区分生理和病理状况或预测癫痫发作的装置和方法。