知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

102 条记录 (耗时 0.029 秒)

    Diagnostic method for disorders using copeptin
    81.
    发明授权
    Diagnostic method for disorders using copeptin 有权
    使用copeptin的疾病诊断方法

    公开(公告)号：US07807397B2

    公开(公告)日：2010-10-05

    申请号：US11573595

    申请日：2005-08-19

    申请人： Andreas Bergmann ,  Joachim Struck

    发明人： Andreas Bergmann ,  Joachim Struck

    IPC分类号： G01N33/00 ,  G01N33/53 ,  A61K38/11

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/5757 ,  Y10S930/15

    摘要： The use of copeptin as diagnostic marker for the determination of the release of vasopressin, especially in connection with disorders associated with non-physiological alterations of vasopressin release from the neurohypophysis, especially for detection and early detection, diagnosing and monitoring of the course of cardiovascular diseases, renal and pulmonary diseases as well as shock, including septic shock, sepsis and diseases/disorders of the central nervous system and neurodegenerative diseases.

    摘要翻译： 使用copeptin作为确定加压素释放的诊断标记，特别是与神经垂体分泌的加压素释放的非生理改变相关的疾病特别是与检测和早期检测，诊断和监测心血管疾病过程相关的疾病 ，肾脏和肺部疾病以及休克，包括脓毒性休克，败血症和中枢神经系统疾病/疾病和神经变性疾病。

    Method for diagnosis of alzheimer's disease with determination of LASP-1 immunoreactivity
    82.
    发明授权
    Method for diagnosis of alzheimer's disease with determination of LASP-1 immunoreactivity 失效
    用于确定LASP-1免疫反应性的阿尔茨海默病的诊断方法

    公开(公告)号：US07763435B2

    公开(公告)日：2010-07-27

    申请号：US12041370

    申请日：2008-03-03

    申请人： Andreas Bergmann ,  Christina Fischer-Schulz ,  Joachim Struck

    发明人： Andreas Bergmann ,  Christina Fischer-Schulz ,  Joachim Struck

    IPC分类号： G01N33/53

    CPC分类号： G01N33/566 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2800/26

    摘要： Method for early diagnosis and diagnosis, for prognosis and assessment of the severity and for therapy-accompanying monitoring of inflammatory diseases and infections, in particular sepsis-like systemic infections and Alzheimer's disease, in which the presence and/or amount of the protein LASP-1 (SEQ ID NO:1) or of the protein LAP-1 (SEQ ID NO:16) or of an immunoreactive fragment of one of these proteins in free and/or protein-bound form is determined, preferably as immunoreactivity, in a biological fluid, or optionally a tissue sample, of a patient, and conclusions are drawn with respect to the presence, the expected course, the severity or the success of a therapy of the inflammatory disease or of the infection from the presence and/or amount of the proteins determined.

    摘要翻译： 用于早期诊断和诊断的方法，用于预测和评估炎性疾病和感染，特别是脓毒症样全身感染和阿尔茨海默氏病的严重性和治疗伴随监测，其中蛋白质LASP- 1（SEQ ID NO：1）或蛋白质LAP-1（SEQ ID NO：16）或这些蛋白质之一的游离和/或蛋白结合形式的免疫反应性片段优选作为免疫反应性 生物流体或任选的组织样品，并且根据存在和/或数量的炎症性疾病或感染的治疗的存在，预期进程，严重程度或成功性得出结论 的蛋白质。

    DIAGNOSIS AND RISK ASSESSMENT OF PANCREATIC DIABETES USING MR-PROADM
    84.
    发明申请
    DIAGNOSIS AND RISK ASSESSMENT OF PANCREATIC DIABETES USING MR-PROADM 审中-公开
    使用MR-PROADM进行胰腺癌的诊断和风险评估

    公开(公告)号：US20100035275A1

    公开(公告)日：2010-02-11

    申请号：US12514194

    申请日：2007-11-08

    申请人： Andreas Bergmann ,  Nils Morgenthaler ,  Jana Papassotiriou ,  Joachim Struck

    发明人： Andreas Bergmann ,  Nils Morgenthaler ,  Jana Papassotiriou ,  Joachim Struck

    IPC分类号： G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2800/042

    摘要： The invention relates to a method for diagnosis and/or risk assessment of pancreatic diabetes, in particular of diabetic sequelae, wherein a determination of the marker mid-regional proAdrenomedullin (MR-proADM: SEQ ID No. 2) or a partial peptide or fragment thereof or if contained in a marker combination (Panel, Cluster) is carried out on a patient under investigation. The invention further relates to a diagnostic device and a kit for carrying out said method.

    摘要翻译： 本发明涉及一种用于胰腺糖尿病，特别是糖尿病后遗症的诊断和/或风险评估的方法，其中确定标记中间区域肾上腺髓质素（MR-proADM：SEQ ID No.2）或部分肽或片段 或者如果包含在标记组合（面板，群集）中，则对被调查的患者进行。 本发明还涉及用于执行所述方法的诊断装置和套件。

    IN VITRO METHOD FOR DIAGNOSING NEURODEGENERATIVE DISEASES
    85.
    发明申请
    IN VITRO METHOD FOR DIAGNOSING NEURODEGENERATIVE DISEASES 审中-公开
    用于诊断神经损伤性疾病的体外方法

    公开(公告)号：US20090311719A1

    公开(公告)日：2009-12-17

    申请号：US12091261

    申请日：2006-10-26

    申请人： Andreas Bergmann ,  Joachim Struck ,  Andrea Ernst

    发明人： Andreas Bergmann ,  Joachim Struck ,  Andrea Ernst

    IPC分类号： C12Q1/25

    CPC分类号： G01N33/6896 ,  C12Q1/34 ,  C12Q1/48

    摘要： Disclosed is an in vitro method for the detection, for the determination of the severity and for the assessment of the progress and prediction of neurodegenerative diseases, in which the presence and/or concentration of carbamoyl phosphate synthetase 1 (CPS 1) is determined in a biological fluid of a patient who suffers from a neurodegenerative disease or is suspected of suffering from such a disease, and conclusions about the presence, progression, severity or success of a treatment of the neurodegenerative disease are drawn on the basis of the determined presence and/or concentration of CPS 1 or the non-detectability of a CPS 1 immune reactivity.

    摘要翻译： 公开了一种体外检测方法，用于确定严重程度和评估神经变性疾病的进展和预测，其中氨基甲酰磷酸合成酶1（CPS 1）的存在和/或浓度在 患有神经变性疾病或怀疑患有这种疾病的患者的生物流体，并且基于所确定的存在和/或结果，绘制关于神经变性疾病的治疗的存在，进展，严重性或成功的结论， 或CPS 1的浓度或CPS1免疫反应性的不可检测性。

    Inflammation-specific peptides and the uses thereof
    88.
    发明授权
    Inflammation-specific peptides and the uses thereof 有权
    炎症特异性肽及其用途

    公开(公告)号：US07153662B2

    公开(公告)日：2006-12-26

    申请号：US10476065

    申请日：2002-04-16

    申请人： Andreas Bergmann ,  Joachim Struck ,  Monika Ühlein

    发明人： Andreas Bergmann ,  Joachim Struck ,  Monika Ühlein

    IPC分类号： G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention relates to novel peptides and partial peptide sequences for the diagnosis and therapy of inflammations and sepsis, which are formed in the case of inflammations and/or infections of primates and humans, and their use or the use of antibodies formed against these peptides in diagnosis and therapy.

    摘要翻译： 本发明涉及用于诊断和治疗炎症和败血症的新肽和部分肽序列，其在灵长类动物和人的炎症和/或感染的情况下形成，以及它们在这些肽中形成的抗体的用途或用途 诊断和治疗。

    Sandwich immunoassay for identifying partial proanp peptides
    89.
    发明申请
    Sandwich immunoassay for identifying partial proanp peptides 有权
    用于鉴定部分脯氨酸肽的三明治免疫测定

    公开(公告)号：US20060234295A1

    公开(公告)日：2006-10-19

    申请号：US10535875

    申请日：2003-10-16

    申请人： Andreas Bergmann ,  Joachim Struck

    发明人： Andreas Bergmann ,  Joachim Struck

    IPC分类号： G01N33/53 ,  C12P21/04

    CPC分类号： G01N33/76 ,  G01N33/6893 ,  G01N2333/58

    摘要： Disclosed is an improved sandwich immunoassay for identifying partial proANP peptides in cardiac and sepsis diagnosis by using two antibodies which specifically bond to partial sequences in the mid-regional area of NT-proANP, extending from amino acid 53 to amino acid 83 of NT-proANP.

    摘要翻译： 公开了通过使用特异性结合NT-proANP的中间区域的部分序列的两种抗体来鉴定心脏和败血症诊断中的部分proANP肽的改进的夹心免疫测定，其从氨基酸53延伸到NT-proANP的氨基酸83 。

    Receptor binding assays and reagent kit for detecting TSH receptor autoantibodies
    90.
    发明授权
    Receptor binding assays and reagent kit for detecting TSH receptor autoantibodies 有权
    用于检测TSH受体自身抗体的受体结合测定和试剂盒

    公开(公告)号：US07015003B1

    公开(公告)日：2006-03-21

    申请号：US09381032

    申请日：1999-01-13

    申请人： Andreas Bergmann ,  Joachim Struck ,  Nils Morgenthaler ,  Wolfgang Weglöhner ,  Jörg-Michael Hollidt

    发明人： Andreas Bergmann ,  Joachim Struck ,  Nils Morgenthaler ,  Wolfgang Weglöhner ,  Jörg-Michael Hollidt

    IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/557 ,  G01N33/542

    CPC分类号： G01N33/564 ,  G01N33/76

    摘要： Improved receptor assays for the detection of thyroid stimulating hormone receptor (TSHR) autoantibodies are described which use immobilized, affinity-purified rTSHR preparations as specific binders. This format, as well as novel measures for neutralizing pathologically increased human TSH (hTSH) levels in the sera, e.g., by the addition of anti-hHSH antibody, and/or eliminating the influence of anti-bovine TSH antibody, result in increased assay reliability and open up the possibility of preparing the assay constituents in a ready to use and/or well-standardized form for automatic processing and/or convenient marketing.

    摘要翻译： 描述了用于检测甲状腺刺激激素受体（TSHR）自身抗体的改进的受体测定法，其使用固定化的亲和纯化的rTSHR制剂作为特异性结合剂。 这种形式，以及用于中和病毒性增加血清中的人TSH（hTSH）水平的新措施，例如通过加入抗hHSH抗体和/或消除抗牛TSH抗体的影响导致增加的测定 并开放了准备使用和/或标准化的形式进行自动处理和/或方便营销的测定成分的可能性。