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1.发明申请METHODS AND SUBSTANCES FOR THE DIAGNOSIS AND THERAPY OF SEPSIS AND SEPSIS-LIKE SYSTEMIC INFECTIONS 有权用于诊断和治疗癫痫和类似系统感染的方法和物质公开(公告)号：US20110008812A1
公开(公告)日：2011-01-13
申请号：US12756235
申请日：2010-04-08
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
摘要翻译： 用于诊断和治疗败血症疾病的重组降钙素原3-116的用途和除降钙素原以外的促激素以及二肽基肽酶IV的测定作为诊断败血症的生物标志物。
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2.发明授权公开(公告)号：US06756483B1
公开(公告)日：2004-06-29
申请号：US09806437
申请日：2001-05-29
IPC分类号： C07K14585
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
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公开(公告)号：US07498139B2
公开(公告)日：2009-03-03
申请号：US10808368
申请日：2004-03-25
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
摘要翻译： 用于诊断和治疗败血症疾病的重组降钙素原3-116的用途和除降钙素原以外的促激素以及二肽基肽酶IV的测定作为诊断败血症的生物标志物。
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4.发明授权Receptor binding assays and reagent kit for detecting TSH receptor autoantibodies 有权用于检测TSH受体自身抗体的受体结合测定和试剂盒公开(公告)号：US07015003B1
公开(公告)日：2006-03-21
申请号：US09381032
申请日：1999-01-13
申请人： Andreas Bergmann , Joachim Struck , Nils Morgenthaler , Wolfgang Weglöhner , Jörg-Michael Hollidt
发明人： Andreas Bergmann , Joachim Struck , Nils Morgenthaler , Wolfgang Weglöhner , Jörg-Michael Hollidt
IPC分类号： G01N33/53 , G01N33/537 , G01N33/557 , G01N33/542
CPC分类号： G01N33/564 , G01N33/76
摘要： Improved receptor assays for the detection of thyroid stimulating hormone receptor (TSHR) autoantibodies are described which use immobilized, affinity-purified rTSHR preparations as specific binders. This format, as well as novel measures for neutralizing pathologically increased human TSH (hTSH) levels in the sera, e.g., by the addition of anti-hHSH antibody, and/or eliminating the influence of anti-bovine TSH antibody, result in increased assay reliability and open up the possibility of preparing the assay constituents in a ready to use and/or well-standardized form for automatic processing and/or convenient marketing.
摘要翻译： 描述了用于检测甲状腺刺激激素受体（TSHR）自身抗体的改进的受体测定法，其使用固定化的亲和纯化的rTSHR制剂作为特异性结合剂。 这种形式，以及用于中和病毒性增加血清中的人TSH（hTSH）水平的新措施，例如通过加入抗hHSH抗体和/或消除抗牛TSH抗体的影响导致增加的测定 并开放了准备使用和/或标准化的形式进行自动处理和/或方便营销的测定成分的可能性。
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5.发明授权公开(公告)号：US08691512B2
公开(公告)日：2014-04-08
申请号：US12756235
申请日：2010-04-08
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
摘要翻译： 用于诊断和治疗败血症疾病的重组降钙素原3-116的用途和除降钙素原以外的促激素以及二肽基肽酶IV的测定作为诊断败血症的生物标志物。
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公开(公告)号：US07998686B2
公开(公告)日：2011-08-16
申请号：US12240485
申请日：2008-09-29
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
摘要翻译： 用于诊断和治疗败血症疾病的重组降钙素原3-116的用途和除降钙素原以外的促激素以及二肽基肽酶IV的测定作为诊断败血症的生物标志物。
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公开(公告)号：US07972799B2
公开(公告)日：2011-07-05
申请号：US12388029
申请日：2009-02-18
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
摘要翻译： 用于诊断和治疗败血症疾病的重组降钙素原3-116的用途和除降钙素原以外的促激素以及二肽基肽酶IV的测定作为诊断败血症的生物标志物。
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公开(公告)号：US07723492B2
公开(公告)日：2010-05-25
申请号：US12240500
申请日：2008-09-29
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.
摘要翻译： 用于诊断和治疗败血症疾病的重组降钙素原3-116的用途和除降钙素原以外的促激素以及二肽基肽酶IV的测定作为诊断败血症的生物标志物。
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公开(公告)号：US10456364B2
公开(公告)日：2019-10-29
申请号：US13034752
申请日：2011-02-25
申请人： Joachim Struck , Andreas Bergmann
发明人： Joachim Struck , Andreas Bergmann
摘要： Subject of the present invention are assays and in vitro methods for the in vitro diagnosis, prognosis and risk stratification of a patient having a primary, non-infectious disease, whereby the level of Procalcitonin (PCT) in a sample of a body fluid of the patient is indicative for the risk of the patient to contract a further disease or medical condition.
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公开(公告)号：US09885709B2
公开(公告)日：2018-02-06
申请号：US10551298
申请日：2004-01-29
申请人： Andreas Bergmann , Joachim Struck
发明人： Andreas Bergmann , Joachim Struck
IPC分类号： G01N33/543 , G01N33/574 , G01N33/68 , G01N33/74
CPC分类号： G01N33/54306 , G01N33/574 , G01N33/6893 , G01N33/74 , G01N2800/26
摘要： Method for the determination of adrenomedullin immunoreactivity in biological fluids for diagnostic purposes, in particular in sepsis, cardiac and cancer diagnosis, in which the midregional partial peptide (mid-proAM; SEQ ID NO:3) of proadrenomedullin, which comprises the amino acids (45-92) of the complete preproadrenomedullin (pre-proAM; SEQ ID NO:1), is measured in particular by means of an immunoassay which operates with at least one labelled antibody which specifically recognizes a sequence of mid-proAM.
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