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81.发明申请公开(公告)号：US20180230165A1
公开(公告)日：2018-08-16
申请号：US15749158
申请日：2016-08-10
发明人： John F. KADOW , B. Narasimhulu NAIDU , Manoj PATEL , Kevin PEESE , Zhongyu WANG
IPC分类号： C07D498/16 , A61P31/18 , C07D498/06
CPC分类号： C07D498/16 , A61K31/4985 , A61P31/18 , C07D498/06 , C07D498/22
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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82.发明申请公开(公告)号：US20180230124A1
公开(公告)日：2018-08-16
申请号：US15749584
申请日：2016-08-10
发明人： Kyle J. EASTMAN , John F. KADOW , B. Narasimhulu NAIDU , Kyle E. PARCELLA , Manoj PATEL , Prasanna SIVAPRAKASAM , Yong TU
IPC分类号： C07D401/04 , A61P31/18
CPC分类号： C07D401/04 , A61K31/5365 , A61K2300/00 , A61P31/18 , C07D401/14 , C07D405/14 , C07D487/04
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV.
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公开(公告)号：US10035760B2
公开(公告)日：2018-07-31
申请号：US15031352
申请日：2014-10-23
发明人： Annapurna Pendri , Guo Li , John A. Bender , Zhong Yang , Alan Xiangdong Wang , Brett R. Beno , Robert A. Fridell , Makonen Belema , Nicholas A. Meanwell , Robert G. Gentles
IPC分类号： A61K31/36 , A61K31/357 , A61K31/64 , A61K31/17 , A61K31/18 , C07C275/28 , C07C275/26 , C07C275/18 , C07C275/24 , C07C275/22 , C07C311/62 , C07C311/59 , C07C311/58 , C07C311/56 , C07C311/55 , C07D317/66 , C07D317/62 , C07D205/04 , C07D209/08 , C07D209/10 , C07D213/56 , C07D215/08 , C07D231/12 , C07D249/08 , C07D261/08 , C07D265/36 , C07D271/06 , C07D277/82 , C07D307/38 , C07D317/46 , C07D333/18 , C07D333/28 , C07D333/54 , C07D401/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D491/08 , C07D495/04
CPC分类号： C07C311/58 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D209/08 , C07D209/10 , C07D213/56 , C07D215/08 , C07D231/12 , C07D249/08 , C07D261/08 , C07D265/36 , C07D271/06 , C07D277/82 , C07D307/38 , C07D317/46 , C07D317/66 , C07D333/18 , C07D333/28 , C07D333/54 , C07D401/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D491/08 , C07D495/04
摘要： Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency virus (HIV) infection, are set forth:
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84.发明申请公开(公告)号：US20180170903A1
公开(公告)日：2018-06-21
申请号：US15578906
申请日：2016-07-06
发明人： John F. KADOW , B. Narasimhulu NAIDU , Tao WANG , Zhiwei YIN
IPC分类号： C07D401/04 , A61P31/18 , A61K31/5365 , A61K31/4545 , A61K31/5377 , C07D405/14 , C07D401/14 , C07D409/14 , A61K31/4725
CPC分类号： C07D401/04 , A61K31/4545 , A61K31/4725 , A61K31/5365 , A61K31/5377 , A61P31/18 , C07D401/14 , C07D405/14 , C07D409/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
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公开(公告)号：US09944656B2
公开(公告)日：2018-04-17
申请号：US15115790
申请日：2015-02-11
发明人： B. Narasimhulu Naidu , Manoj Patel
IPC分类号： C07D513/16 , C07D513/22 , C07D515/22
CPC分类号： C07D513/22 , C07D513/16 , C07D515/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US09932353B2
公开(公告)日：2018-04-03
申请号：US15119446
申请日：2015-02-13
发明人： B. Narasimhulu Naidu , Manoj Patel
IPC分类号： C07D498/22 , A61K31/529 , A61K45/06
CPC分类号： C07D498/22 , A61K31/529 , A61K45/06
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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公开(公告)号：US20180086697A1
公开(公告)日：2018-03-29
申请号：US15565690
申请日：2016-04-22
发明人： John A. BENDER , Robert G. GENTLES , Annapurna PENDRI , Alan Xiangdong WANG , Nicholas A. MEANWELL , Brett R. BENO , Robert A. FRIDELL , Makonen BELEMA , Van N. NGUYEN , Zhong YANG , Gan WANG , Selvakumar KUMARAVEL , Srinivasan THANGATHIRUPATHY , Rajesh Onkardas BORA , Shilpa Maheshwarappa HOLEHATTI , Mallikarjuna Rao METTU , Manoranjan PANDA
IPC分类号： C07C307/06 , C07C307/10 , C07C311/08 , A61P31/18
CPC分类号： C07C307/06 , A61P31/18 , C07C307/10 , C07C311/08 , C07C2601/14 , C07C2602/08 , C07D205/04 , C07D207/325 , C07D209/08 , C07D209/30 , C07D209/32 , C07D209/86 , C07D211/96 , C07D213/42 , C07D215/12 , C07D215/38 , C07D217/08 , C07D217/22 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/08 , C07D241/04 , C07D249/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/62 , C07D295/185 , C07D295/26 , C07D333/72 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
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公开(公告)号：US20170334946A1
公开(公告)日：2017-11-23
申请号：US15524298
申请日：2015-11-12
IPC分类号： C07J63/00
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US09655889B2
公开(公告)日：2017-05-23
申请号：US14770702
申请日：2014-03-10
发明人： Kevin Peese , Zhongyu Wang , John F. Kadow , B. Narasimhulu Naidu
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , A61K31/4545 , C07D471/04 , A61K45/06
CPC分类号： A61K31/4545 , A61K45/06 , C07D471/04
摘要： The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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90.发明授权公开(公告)号：US09637501B2
公开(公告)日：2017-05-02
申请号：US15119488
申请日：2015-02-19
发明人： B. Narasimhulu Naidu
IPC分类号： A61K31/4545 , C07D401/04 , C07D498/18
CPC分类号： C07D498/18 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
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