Chimeric amino acid analogues
    82.
    发明授权
    Chimeric amino acid analogues 失效
    CHIMERIC氨基酸类似物

    公开(公告)号:US5120859A

    公开(公告)日:1992-06-09

    申请号:US411088

    申请日:1989-09-22

    Applicant: Thomas R. Webb

    Inventor: Thomas R. Webb

    CPC classification number: C07K7/06 C07D207/16 C07K5/1024 A61K38/00

    Abstract: A chimeric amino acid analogue is provided suitable for incorporating into peptides which compound is represented by Formula 1: ##STR1## where P.sub.1 is preferably an amine protecting agent, and P.sub.2 and P.sub.3 are preferably amine or guanidine protecting agents. X can be OH, halide, or preferably an activating group suitable for conjugating the compound of Formula 1 to a peptide by conventional means, and m and n are 0-1 and 0-2 respectively.Peptides containing the chimeric amino acid analog are provided and include a platelet-aggregation inhibitor represented byAaa.sub.1 -CPdl-Gly-Asp-Aaa.sub.2where Aaa.sub.1 is Gly or H, Cpdl is the compound of Formula 1 which has been deprotected and Aaa.sub.2 is a hydrophobic amino acid preferably Val.

    Abstract translation: 提供了一种嵌合氨基酸类似物,其适于掺入到化合物由式1表示的肽中:其中P1优选为胺保护剂,P2和P3优选为胺或胍保护剂。 X可以是OH,卤化物,或优选是适合于通过常规方法将式1化合物与肽缀合的活化基团,m和n分别为0-1和0-2。 提供含有嵌合氨基酸类似物的肽,包括由Aaa1-CPd1-Gly-Asp-Aaa2表示的血小板聚集抑制剂,其中Aaa1为Gly或H,Cpd1为脱保护的式1化合物,Aaa2为疏水基 氨基酸优选为Val。

    Support for solid-phase oligonucleotide synthesis

    公开(公告)号:US4659774A

    公开(公告)日:1987-04-21

    申请号:US794016

    申请日:1985-11-01

    CPC classification number: C07H21/00 C08F8/32

    Abstract: This invention relates to a support for oligonucleotide synthesis and more particularly to a necleoside-linker/polymer support composite having the general formulaP'--S'wherein P' is a polymer support which bears oxirane, aziridine or episulfide groups or which contains good leaving groups for nucleophilic displacement; and S' is a nucleoside-linker having the general formulaW--(CH.sub.2).sub.a --X--(CH.sub.2).sub.b --Y--(CH.sub.2).sub.c --Zwherein W and Z each independently comprise a nucleophile; X and Y which, independently may or may not be present, comprise groups of high hydrophilicity; and a, b, c are integers from 0 to 9, wherein a plus b plus c exceeds 6.

    Piston positioning indicator
    84.
    发明授权
    Piston positioning indicator 失效
    活塞定位指示器

    公开(公告)号:US4140045A

    公开(公告)日:1979-02-20

    申请号:US769308

    申请日:1977-02-16

    CPC classification number: F01B25/26

    Abstract: In a piston actuated valve, means for determining the position of the operating piston by means of at least one insulated contact probe which is inserted through the wall of the cylinder. Two or more can be used, one in each extreme position of the piston. As the piston moves into its extreme position, contact is made with the probe and a suitable signal is sent, indicating that the piston is in that extreme position.

    Abstract translation: 在活塞致动阀中,用于通过至少一个绝缘接触探头来确定操作活塞的位置的装置,所述至少一个绝缘接触探针穿过气缸的壁。 可以使用两个或更多个,一个在活塞的每个极限位置。 当活塞移动到其极限位置时,用探头进行接触,并发送适当的信号,表明活塞处于极限位置。

    Round tray
    85.
    发明授权
    Round tray 失效
    圆托盘

    公开(公告)号:US4124160A

    公开(公告)日:1978-11-07

    申请号:US820315

    申请日:1977-07-29

    CPC classification number: B65D5/2019

    Abstract: A round tray and a blank for making the tray. The tray has a bottom panel, a plurality of intermediate panels symetrically disposed about the center of the bottom panel, and a plurality of upstanding panels to form the sides of the tray. The upstanding panels may be tilted slightly outward in a conical shape to cause the diameter of the top of the tray to be slightly larger than the diameter of the bottom of the tray. Alternate ones of the upstanding panels are positioned on the inside of the tray, and their adjacent upstanding panels have circumferentially extending glue flaps which overlap the inner panels. The total number of upstanding panels and the total number of intermediate panels are equal, with each upstanding panel being foldable relative to an intermediate panel immediately below it about a first set of fold or score lines. The intermediate panels, in turn, are folded upward from the horizontal about a second set of fold or score lines. The boundaries of the intermediate panels are each formed by a score line from the first set and a score line from the second set of score lines, the first and second score lines of a particular panel coming together at points on the edges of the intermediate panel and on the edges of the upstanding panels. A point of intersection of the first and second score lines which define the edges of an intermediate panel is also the point of intersection for the first and second score lines of the next adjacent intermediate panel. Those points of intersection are formed on a circle about the center of the base panel but elevated slightly above the plane of the base panel.

    Abstract translation: 一个圆盘和一个用于制作托盘的空白。 托盘具有底板,围绕底板的中心对称配置的多个中间板以及多个直立板以形成托盘的侧面。 直立的面板可以稍微向外倾斜成圆锥形,以使托盘顶部的直径略大于托盘底部的直径。 直立面板中的另一个定位在托盘的内侧,并且其相邻的直立面板具有与内板重叠的周向延伸的胶片。 直立面板的总数和中间面板的总数相等,每个直立面板相对于其正下方的中间面板绕第一组折叠或刻痕线折叠。 中间面板依次从水平面向上折叠成第二组折叠或刻痕线。 中间面板的边界各自由来自第一组的刻痕线和来自第二组刻痕线的刻痕线形成,特定面板的第一和第二刻痕线在中间面板的边缘上的点处在一起 并在直立面板的边缘。 限定中间面板的边缘的第一和第二刻痕线的交点也是下一相邻中间面板的第一和第二刻痕线的交点。 这些交叉点形成在围绕基板的中心的圆上,但稍微高于基板的平面。

    Method and apparatus for tunneling upwardly
    86.
    发明授权
    Method and apparatus for tunneling upwardly 失效
    向上隧道的方法和装置

    公开(公告)号:US4114698A

    公开(公告)日:1978-09-19

    申请号:US551083

    申请日:1975-02-20

    CPC classification number: E21B17/07 E21D3/00

    Abstract: A vertical thrust boring machine adapted to be positioned in the horizontal drift of a mine and to cut a tunnel extending upwardly from the drift so as to remove ore or other cuttings therefrom. The machine includes a rotary table for lifting a drill string which in turn supports the cutter head, and is characterized by drill stem sections having a spline connection on their lower ends, and a drive coupling ring associated with the rotary platform having a mating spline connection, so that when changing the length of the drill string the lowermost drill stem section can slide or float vertically relative to the rotary platform at the same time that it is being drivingly rotated.

    Abstract translation: 一种垂直推力镗床,适于定位在矿井的水平漂移中,并切割从漂移物向上延伸的隧道,以便从其中移除矿石或其他钻屑。 该机器包括用于提升钻柱的旋转台,该钻柱又支撑刀头,并且其特征在于在其下端具有花键连接的钻杆段和与旋转平台相关联的驱动联接环,该旋转平台具有配合的花键连接 ,使得当改变钻柱的长度时,最下面的钻杆部分可以在其被驱动旋转的同时相对于旋转平台垂直地滑动或浮动。

    Pumping assembly using active materials
    90.
    发明授权
    Pumping assembly using active materials 有权
    泵组件采用活性材料

    公开(公告)号:US08776515B2

    公开(公告)日:2014-07-15

    申请号:US13280387

    申请日:2011-10-25

    CPC classification number: F03G7/065 F04B9/02 F04B19/22 F04B53/14 F05C2251/08

    Abstract: A pumping assembly is provided. The assembly includes a first movable element selectively movable within a first pump housing and an actuator including an active material. The active material is configured to undergo a change in attribute in response to an activation signal. The active material is operatively connected to the first movable element such that the change in attribute causes the first movable element to move within the first pump housing. In one example, the active material is a shape memory alloy material having a crystallographic phase that is changeable between Austenite and Martensite in response to the activation signal.

    Abstract translation: 提供泵组件。 组件包括可在第一泵壳体内选择性地移动的第一可移动元件和包括活性材料的致动器。 活动材料被配置为响应于激活信号而经历属性的改变。 活性材料可操作地连接到第一可移动元件,使得属性的变化使得第一可移动元件在第一泵壳体内移动。 在一个实例中,活性材料是具有响应于激活信号在奥氏体和马氏体之间变化的晶体相的形状记忆合金材料。

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