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    Method Of Identifying A Drug For Patient-Specific Treatment
    82.
    发明公开
    Method Of Identifying A Drug For Patient-Specific Treatment 审中-公开

    公开(公告)号：US20230245743A1

    公开(公告)日：2023-08-03

    申请号：US18015892

    申请日：2021-07-15

    申请人： Queen Mary University of London

    发明人： Pedro Rodriguez Cutillas

    IPC分类号： G16H20/10 ,  G16H70/40

    CPC分类号： G16H20/10 ,  G16H70/40

    摘要： The present invention provides a computer-implemented method of identifying a drug with which to y treat a patient, the method comprising the steps of : a. providing a dataset of expression values of biological markers from a sample taken from said patient; b. using said dataset of expression values to calculate a plurality of drug response distance values Dn for each of a plurality of drugs dn, wherein D for each drug d is the difference between the distribution of expression of biological markers of sensitivity to drug d relative to the distribution of expression of biological markers of resistance to drug d; c. providing one or more trained predictive models, wherein the one or more trained predictive models have been trained on a plurality of drug response distance values Dn for at least the same plurality of drugs dn as in step b; and wherein the one or more trained predictive models have been trained to provide a ranking of the drugs from said plurality of drugs dn in order of their predicted efficacy in said sample taken from said patient; d. inputting said plurality of drug response distance values Dn obtained in step b. into said one or more trained predictive models; and e. providing, using one or more of the trained predictive models, a ranking of the drugs from said plurality of drugs do in order of their predicted efficacy in said patient.

    TIME-VARYING AND NONLINEAR AUDIO PROCESSING USING DEEP NEURAL NETWORKS
    83.
    发明公开
    TIME-VARYING AND NONLINEAR AUDIO PROCESSING USING DEEP NEURAL NETWORKS 审中-公开

    公开(公告)号：US20230197043A1

    公开(公告)日：2023-06-22

    申请号：US17924701

    申请日：2020-05-12

    申请人： QUEEN MARY UNIVERSITY OF LONDON

    发明人： Marco Antonio MARTINEZ RAMIREZ ,  Joshua Daniel REISS ,  Emmanouil BENETOS

    IPC分类号： G10H1/00 ,  G10H1/16 ,  G06N3/045 ,  G06N3/0442 ,  G06N3/0499 ,  G06N3/08

    CPC分类号： G10H1/0091 ,  G10H1/16 ,  G06N3/045 ,  G06N3/0442 ,  G06N3/0499 ,  G06N3/08 ,  G10H2210/311 ,  G10H2250/311 ,  G10H2210/215 ,  G10H2210/281 ,  G10H2250/025

    摘要： A computer-implemented method of processing audio data, the method comprising receiving input audio data (x) comprising a time-series of amplitude values; transforming the input audio data (x) into an input frequency band decomposition (X1) of the input audio data (x); transforming the input frequency band decomposition (X1) into a first latent representation (Z); processing the first latent representation (Z) by a first deep neural network to obtain a second latent representation (Z{circumflex over ( )}, Z1{circumflex over ( )}); transforming the second latent representation (Z{circumflex over ( )}, Z1{circumflex over ( )}) to obtain a discrete approximation (X3{circumflex over ( )}); element-wise multiplying the discrete approximation (X3{circumflex over ( )}) and a residual feature map (R, X5{circumflex over ( )}) to obtain a modified feature map, wherein the residual feature map (R, X5{circumflex over ( )}) is derived from the input frequency band decomposition (X1); processing a pre-shaped frequency band decomposition by a waveshaping unit to obtain a waveshaped frequency band decomposition (X1{circumflex over ( )}, X1.2{circumflex over ( )}), wherein the pre-shaped frequency band decomposition is derived from the input frequency band decomposition (X1), wherein the waveshaping unit comprises a second deep neural network; summing the waveshaped frequency band decomposition (X1{circumflex over ( )}, X1.2{circumflex over ( )}) and a modified frequency band decomposition (X2{circumflex over ( )}, X1.1{circumflex over ( )}) to obtain a summation output (X0{circumflex over ( )}), wherein the modified frequency band decomposition (X2{circumflex over ( )}, X1.1{circumflex over ( )}) is derived from the modified feature map; and transforming the summation output (X0{circumflex over ( )}) to obtain target audio data (y{circumflex over ( )}).

    DIAGNOSTICS
    85.
    发明申请
    DIAGNOSTICS 有权

    公开(公告)号：US20230043193A1

    公开(公告)日：2023-02-09

    申请号：US17867792

    申请日：2022-07-19

    申请人： Queen Mary University of London

    发明人： Gareth Ackland

    IPC分类号： G01N33/50 ,  C12Q1/26 ,  C12Q1/00 ,  G01N33/68

    摘要： The present invention relates to the detection or diagnosis of infection or inflammation in a patient. In particular, the invention provides methods that allow the detection of markers in a sample from a patient or subject, such as a blood sample, which will indicate whether the patient or subject has an infection or has an inflammatory response.

    Electrodeposition from multiple electrolytes
    86.
    发明授权
    Electrodeposition from multiple electrolytes 有权

    公开(公告)号：US11542622B2

    公开(公告)日：2023-01-03

    申请号：US16631610

    申请日：2018-07-17

    申请人： Queen Mary University of London ,  Morganic Solutions Ltd.

    发明人： Andrew John Bushby ,  Ross Morgan

    IPC分类号： C25D17/00 ,  C25D1/00 ,  C25D17/02 ,  C25D21/08 ,  C25D5/10

    摘要： EL The present invention provides a system for electrodepositing a plurality of electrolytes onto a substrate in a single deposition chamber to form an article, in which the system comprises a removable substrate; a deposition chamber containing the substrate in which the chamber has an inlet and an outlet and in which the chamber comprises at least one anode with connection to a source of electrical current; a plurality of electrolyte reservoirs for an electrolyte solution connected to the deposition chamber through the inlet; and a rinse medium reservoir connected to the deposition chamber through the inlet. Also provided is a system comprising a cradle to form an article, methods using the systems of the invention, and composite materials and devices prepared by the methods of the invention.

    Mechanical circulatory support device with axial flow turbomachine optimized for heart failure and cardio-renal syndrome by implantation in the descending aorta
    87.
    发明授权
    Mechanical circulatory support device with axial flow turbomachine optimized for heart failure and cardio-renal syndrome by implantation in the descending aorta 有权

    公开(公告)号：US11524153B2

    公开(公告)日：2022-12-13

    申请号：US16338961

    申请日：2017-09-29

    申请人： Queen Mary University of London

    发明人： Theodosios Alexander ,  Martin T. Rothman

    IPC分类号： A61M60/135 ,  A61M60/419 ,  A61M60/861 ,  A61M60/422

    摘要： Mechanical circulatory supports configured to operate in series with the native heart are disclosed. In an embodiment, an intravascular propeller is installed into the descending aorta and anchored within via an expandable anchoring mechanism. The propeller and anchoring mechanism may be foldable so as to be percutaneously deliverable to the aorta. The propeller may have foldable blades. The blades may be magnetic and may be driven by a concentric electromagnetic stator circumferentially outside the magnetic blades. The stator may be intravascular or may be configured to be installed around the outer circumference of the blood vessel. The support may create a pressure rise between about 20-50 mmHg, and maintain a flow rate of about 5 L/min. The support may have one or more pairs of contra-rotating propellers to modulate the tangential velocity of the blood flow. The support may have static pre-swirlers and or de-swirlers. The support may be optimized to replicate naturally occurring vortex formation within the descending aorta.

    Diagnostics
    88.
    发明授权
    Diagnostics 有权

    公开(公告)号：US11415573B2

    公开(公告)日：2022-08-16

    申请号：US15324316

    申请日：2015-07-08

    申请人： Queen Mary University of London

    发明人： Gareth Ackland

    IPC分类号： G01N33/50 ,  C12Q1/26 ,  C12Q1/00 ,  G01N33/68

    摘要： The present invention relates to the detection or diagnosis of infection or inflammation in a patient. In particular, the invention provides methods that allow the detection of markers in a sample from a patient or subject, such as a blood sample, which will indicate whether the patient or subject has an infection or has an inflammatory response.