公开(公告)号：US07064190B1

公开(公告)日：2006-06-20

申请号：US09441061

申请日：1999-11-16

申请人： Josef Endl ,  Peter Stahl ,  Winfried Albert ,  Guenther-Gerhard Jung ,  Dolores J. Schendel ,  Edgar Meinl ,  Klaus Dornmair

发明人： Josef Endl ,  Peter Stahl ,  Winfried Albert ,  Guenther-Gerhard Jung ,  Dolores J. Schendel ,  Edgar Meinl ,  Klaus Dornmair

IPC分类号： C07K14/74 ,  C07K16/00

CPC分类号： C07K14/70539 ,  A61K35/17 ,  A61K38/19 ,  C12N9/88 ,  G01N33/56977 ,  A61K2300/00

摘要： The invention concerns autoreactive peptides, peptide-MHC complexes, T cell subpopulations that react thereto as well as diagnostic and therapeutic applications of these compounds.

摘要翻译： 本发明涉及自身反应肽，肽-MHC复合物，与其反应的T细胞亚群以及这些化合物的诊断和治疗应用。

公开(公告)号：US07054471B2

公开(公告)日：2006-05-30

申请号：US10848363

申请日：2004-05-19

申请人： Jon Tschudi

发明人： Jon Tschudi

IPC分类号： G06K9/00

CPC分类号： G06K9/00026 ,  A61B5/1172 ,  G06K9/0002

摘要： A plurality of images of portions of a fingerprint surface is generated by measuring structural features the portions of the surface with a sensor array as the surface is moved relative to the array. A two-dimensional image of the fingerprint surface is constructed from a portion of the plurality of images. In one embodiment, a varying voltage is applied to a finger positioned over an exciting electrode and a capacitive sensor array, and the capacitance or impedance through the finger is measured between the electrode and the array to detect variations in capacitance or impedance caused by variations in the structural features of the fingerprint surface. In one embodiment, the speed of the fingerprint surface relative to the sensor array is determined by sensing features of the fingerprint surface at two spaced-apart sensing elements and determining the speed from the distance between the sensing elements and the time lapse between passage of identical features of the fingerprint surface from one of the sensing elements to the other.

摘要翻译： 当表面相对于阵列移动时，通过用传感器阵列测量表面的部分的结构特征来生成指纹表面的多个图像。 指纹表面的二维图像由多个图像的一部分构成。 在一个实施例中，将变化的电压施加到位于激励电极和电容传感器阵列上的手指上，并且在电极和阵列之间测量通过手指的电容或阻抗，以检测由变化引起的电容或阻抗的变化 指纹表面的结构特征。 在一个实施例中，指纹表面相对于传感器阵列的速度通过在两个间隔开的感测元件处感测指纹表面的特征来确定，并且从感测元件之间的距离和相同的通过之间的时间流逝确定速度 指纹表面的特征从感测元件之一到另一个。

公开(公告)号：US07052717B2

公开(公告)日：2006-05-30

申请号：US10441259

申请日：2003-05-20

申请人： Dwight D. Hanshew, Jr. ,  David John Wargo

发明人： Dwight D. Hanshew, Jr. ,  David John Wargo

IPC分类号： A61K9/20

CPC分类号： A61K9/2013 ,  A61K9/2018 ,  A61K31/198 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26

摘要： This invention provides a storage-stable dosage form of a thyroxine active drug composition which exhibits an improved stability. The formulation contains a thyroxine active drug substance and an antioxidant, and, optionally, additional pharmaceutically accepted excipients. Levothyroxine sodium is the preferred active drug substance, butylated hydroxyanisole is the preferred antioxidant. Additional preferred excipients include, for example, microcrystalline cellulose, sucrose, mannitol, crospovidone, magnesium stearate, colloidal silicon dioxide, and sodium lauryl sulfate.

摘要翻译： 本发明提供了具有改善的稳定性的甲状腺素活性药物组合物的储存稳定剂型。 该制剂含有甲状腺素活性药物物质和抗氧化剂，以及任选的其它药学上可接受的赋形剂。 左旋甲状腺素钠是优选的活性药物，丁基化羟基苯甲醚是优选的抗氧化剂。 另外优选的赋形剂包括例如微晶纤维素，蔗糖，甘露糖醇，交聚维酮，硬脂酸镁，胶体二氧化硅和月桂基硫酸钠。

公开(公告)号：US07039436B1

公开(公告)日：2006-05-02

申请号：US09936293

申请日：2000-01-12

申请人： Yuji Kakehi

发明人： Yuji Kakehi

IPC分类号： H04B7/00 ,  H04Q7/20

CPC分类号： H04W48/16 ,  H04B7/022 ,  H04W48/20 ,  H04W88/02

摘要： A mobile communication terminal includes a receiver (2) receiving a radio waves from a base station, a sampling unit (3) sampling a signal received by the receiver (2), a demodulator (5) demodulating the signal sampled by the sampling unit (3), a selector (4) selecting a most significant cell/sector based on data demodulated by the demodulator (5), using at least two different thresholds, and a path detector (6) detecting a primary path based on the signal sampled by the sampling unit (3). Since the selector (4) selects the most significant cell/sector based on the signal sampled by the sampling unit (3), using at least two different thresholds, it is possible to prevent deterioration of the receiving quality due to frequent transition of the main selector.

摘要翻译： 移动通信终端包括接收来自基站的无线电波的接收机（2），对由接收机（2）接收的信号进行采样的采样单元（3），解调器（5），解调由采样单元 3），选择器（4）基于由解调器（5）解调的数据，使用至少两个不同的阈值来选择最重要的小区/扇区;以及路径检测器（6），其基于由 采样单元（3）。 由于选择器（4）基于由采样单元（3）采样的信号来选择最高有效单元/扇区，所以使用至少两个不同的阈值，可以防止由于主频率的频繁转换导致的接收质量的恶化 选择器。

公开(公告)号：US07007644B2

公开(公告)日：2006-03-07

申请号：US10726688

申请日：2003-12-04

申请人： Chun Tai ,  Timothy A. Suder ,  Walter Curtis Jacques ,  Benjamin C. Shade

发明人： Chun Tai ,  Timothy A. Suder ,  Walter Curtis Jacques ,  Benjamin C. Shade

IPC分类号： F01L9/02

CPC分类号： F01L9/021 ,  F01L1/08 ,  F01L2001/34446 ,  F01L2800/12

摘要： A valve actuation system and method for use in an internal combustion engine including at least one combustion cylinder having a piston and an engine valve. The valve actuation system includes a hydraulic pump, a high-pressure reservoir, and an electro-hydraulic valve actuator. The hydraulic pump is configured to produce a hydraulic output based on a valve-piston clearance profile of at least one cylinder of the combustion engine. The high-pressure reservoir is coupled with the hydraulic pump. The electro-hydraulic valve actuator is coupled with the high-pressure reservoir via a first control valve and configured to actuate at least one engine valve of the combustion engine according to an output of the hydraulic pump.

摘要翻译： 一种用于内燃机的气门致动系统和方法，所述内燃机包括至少一个具有活塞和发动机气门的燃烧气缸。 阀致动系统包括液压泵，高压储存器和电动液压阀致动器。 液压泵构造成基于内燃机的至少一个气缸的阀 - 活塞间隙轮廓产生液压输出。 高压储罐与液压泵相连。 电动液压阀致动器经由第一控制阀与高压储存器联接，并且构造成根据液压泵的输出致动内燃机的至少一个发动机阀。

公开(公告)号：US06936632B2

公开(公告)日：2005-08-30

申请号：US10169988

申请日：2001-01-12

申请人： Hans-Guenter Striegel ,  Stefan Laufer ,  Karola Tollmann ,  Susanne Tries

发明人： Hans-Guenter Striegel ,  Stefan Laufer ,  Karola Tollmann ,  Susanne Tries

IPC分类号： A61K31/407 ,  A61P1/04 ,  A61P9/10 ,  A61P29/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/403 ,  C07D209/02

CPC分类号： C07D487/04

摘要： The present invention relates to fused pyrrole compounds of the formula 1. in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl. These compounds are in particular pyrrolizines, indolizines and heteroanalogues having selective inhibitory action on isoenzyme-2 of prostaglandin H synthase (COX-2). The invention also relates to pharmaceutical compositions which contain these compounds; and the use of these compounds for the treatment of disorders of the rheumatic type.

摘要翻译： 本发明涉及式1的稠合吡咯化合物，其中基团R 1，R 2，R 3中的至少一个是4-硫取代的苯基。 这些化合物特别是对前列腺素H合成酶（COX-2）的同工酶-2具有选择性抑制作用的吡咯烷，中氮茚和杂芳族化合物。 本发明还涉及含有这些化合物的药物组合物; 以及这些化合物用于治疗风湿性疾病的用途。

公开(公告)号：US06848413B1

公开(公告)日：2005-02-01

申请号：US10726684

申请日：2003-12-04

申请人： Timothy A. Suder ,  Steven Stuart Trevitz ,  Benjamin C. Shade ,  Chun Tai

发明人： Timothy A. Suder ,  Steven Stuart Trevitz ,  Benjamin C. Shade ,  Chun Tai

IPC分类号： F01L1/44 ,  F02B1/12 ,  F02B19/00 ,  F02D41/30 ,  G02D19/18

CPC分类号： F01L1/44 ,  F01L1/08 ,  F01L9/02 ,  F01L9/04 ,  F02B1/12 ,  F02B19/00 ,  F02D41/3041 ,  Y02T10/125

摘要： An internal combustion cylinder assembly includes a cylinder having a combustion chamber and a piston. An intake valve provides a working fluid to the combustion chamber while the piston moves from a top dead center position to a bottom dead center position. A pre-combustion chamber is connected communicably to the combustion chamber via a Suder valve and conveys a portion of the working fluid to the pre-combustion chamber while the Suder valve is substantially open. The Suder valve may open substantially simultaneously with the intake valve, remain substantially open while the piston moves from the top dead center position to the bottom dead center position during an intake stroke, and close substantially while the piston is returning to the top dead center position during a compression stroke.

摘要翻译： 内燃缸组件包括具有燃烧室和活塞的气缸。 当活塞从上止点位置移动到下死点位置时，进气阀向燃烧室提供工作流体。 预燃烧室经由Suder阀可通信地连接到燃烧室，并且在Suder阀基本上打开的同时将一部分工作流体输送到预燃烧室。 当阀门进气行程过程中活塞从上死点位置移动到下止点位置时，阀门基本上与进气阀同时打开，保持基本上打开，而当活塞返回到上止点位置时， 在压缩冲程期间。

公开(公告)号：US10787702B2

公开(公告)日：2020-09-29

申请号：US16539258

申请日：2019-08-13

申请人： ArcticZymes AS ,  Universitetet I Tromsø—Norges Arktiske Universitet

发明人： Terese Solstad ,  Elisabeth Lill Andreassen ,  Marit Sjo Lorentzen ,  Olav Lanes ,  Morten Elde ,  Atle Noralf Larsen ,  Yvonne Piotrowski ,  Nils Peder Willassen

IPC分类号： C12Q1/6869 ,  C12Q1/6844 ,  C12N9/22 ,  C12Q1/6848 ,  C12Q1/34 ,  G01N1/30

摘要： The invention provides an exonuclease or an enzymatically active fragment thereof, said exonuclease having the amino acid sequence of SEQ ID NO:1 or an amino acid sequence which is at least about 50% identical thereto, wherein said exonuclease or enzymatically active fragment thereof (i) is substantially irreversibly inactivated by heating at a temperature of about 55° C. for 10 minutes in a buffer consisting of 10 mM Tris-HCl, pH 8.5 at 25° C., 50 mM KCl and 5 mM MgCl2; (ii) is substantially specific for single stranded DNA; and (iii) has a 3′-5′ exonuclease activity. The invention further provides a method of removing single stranded DNA from a sample, a method of nucleic acid amplification, a method of reverse transcription and a method of nucleic acid sequence analysis in which the exonuclease or enzymatically active fragment thereof is used. The invention still further provides nucleic acids encoding said exonuclease or an enzymatically active fragment thereof and kits or compositions comprising the same.

公开(公告)号：US09598722B2

公开(公告)日：2017-03-21

申请号：US14538533

申请日：2014-11-11

申请人： GENMARK DIAGNOSTICS, INC.

发明人： David Walter Wright ,  Dominic Aiello ,  Peter Kroehl ,  Jon Faiz Kayyem ,  Darren Scott Gray

IPC分类号： G01N21/75 ,  C12Q1/68 ,  C12N15/10 ,  B01F7/00 ,  B01F15/00 ,  B01L3/00 ,  B01L7/00

CPC分类号： C12Q1/6825 ,  B01F7/00116 ,  B01F7/00133 ,  B01F7/00141 ,  B01F7/003 ,  B01F7/00341 ,  B01F13/0094 ,  B01F15/00006 ,  B01F15/00318 ,  B01F15/00538 ,  B01F2215/0037 ,  B01L3/502738 ,  B01L3/502784 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/161 ,  B01L2300/1822 ,  B01L2400/0427 ,  B01L2400/0481 ,  B01L2400/0683 ,  C12N15/1006

摘要： In one embodiment, a multiplex fluid processing cartridge includes a sample well, a deformable fluid chamber, a mixing well with a mixer disposed therein, a lysis chamber including a lysis mixer, an electrowetting grid for microdroplet manipulation, and electrosensor arrays configured to detect analytes of interest. An instrument for processing the cartridge is configured to receive the cartridge and to selectively apply thermal energy, magnetic force, and electrical connections to one or more discrete locations on the cartridge and is further configured to compress the deformable chamber(s) in a specified sequence.

公开(公告)号：USD774493S1

公开(公告)日：2016-12-20

申请号：US29564954

申请日：2016-05-17

申请人： SKY UK LIMITED

设计人： Andrew Wong ,  Christopher Kuh