公开(公告)号：US11773151B2

公开(公告)日：2023-10-03

申请号：US17488852

申请日：2021-09-29

申请人： Akston Biosciences Corporation

发明人： Thomas M. Lancaster ,  Todd C. Zion

IPC分类号： C07K14/62 ,  A61P3/10 ,  A61K9/00 ,  C07K16/28 ,  C12N15/62 ,  A61K47/65 ,  C07K1/22 ,  C07H21/04 ,  A61K38/00

CPC分类号： C07K14/62 ,  A61K9/0019 ,  A61K47/65 ,  A61P3/10 ,  C07H21/04 ,  C07K1/22 ,  C07K16/2869 ,  C12N15/62 ,  A61K38/00 ,  C07K2317/94 ,  C07K2319/30

摘要： The present disclosure provides recombinantly manufactured ultra-long acting insulin-Fc fusion proteins for use in treating canine and feline diabetes. The insulin-Fc fusion proteins comprise an insulin polypeptide linked via a peptide linker to an Fc-fragment of canine or feline origin. Based on the results obtained, creating a treatment that is amenable to low cost manufacturing, exhibits sufficient in vivo bioactivity, displays extended duration of bioactivity, does not induce anti-drug antibodies, and substantially retains is potency over multiple administrations, requires a non-obvious combination of insulin polypeptide, peptide linkers, and species-specific Fc fragment, in addition to selective mutations on one or more of these components. Exemplary ultra-long acting insulin-Fc fusion proteins, polynucleotides encoding these insulin-Fc fusion proteins, and pharmaceutical formulations of exemplary insulin-Fc fusion proteins are provided, in addition to methods of use and preparation.

公开(公告)号：US20230272405A1

公开(公告)日：2023-08-31

申请号：US18012143

申请日：2021-06-22

申请人： University of Connecticut

发明人： Paulo Henrique Verardi ,  Brittany Jasperse ,  Caitlin M. O’Connell ,  Yuxiang Wang

IPC分类号： C12N15/62 ,  C07K14/005 ,  C12N15/86 ,  A61K39/12 ,  A61P31/14

CPC分类号： C12N15/625 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5258

摘要： Disclosed herein are flavivirus signal peptide mutants useful for enhancing the production and secretion of flavivirus envelope (E) viral proteins or virus-like proteins. Also disclosed herein are methods of vaccinating subjects (e.g., human subjects) against a flavivirus comprising administering an expression vector, wherein the expression vector comprises a polynucleotide, and a fusion polypeptide comprising an engineered signal peptide and a flavivirus envelope (E) protein

公开(公告)号：US20230272355A1

公开(公告)日：2023-08-31

申请号：US18000634

申请日：2021-06-04

申请人： B-MOGEN BIOTECHNOLOGIES, INC.

发明人： David Largaespada ,  Branden Moriarity ,  Beau Webber ,  Neil Otto ,  Sandeep Kumar ,  Bryan Jones

IPC分类号： C12N9/12 ,  C12N9/22 ,  C12N15/63 ,  C12N15/62 ,  C12N5/0783 ,  A61K35/17 ,  A61P35/00

CPC分类号： C12N9/1241 ,  C12N9/22 ,  C12N15/63 ,  C12N15/62 ,  C12N5/0636 ,  A61K35/17 ,  A61P35/00 ,  C12N2510/00

摘要： This disclosure provides various SPIN transposases and transposons, systems, and methods of use.

公开(公告)号：US20230272045A1

公开(公告)日：2023-08-31

申请号：US18001480

申请日：2021-06-11

申请人： MONASH UNIVERSITY

发明人： Mikaël MARTINO ,  Ziad JULIER

IPC分类号： C07K14/715 ,  C07K14/475 ,  C12N15/62 ,  A61P17/02 ,  C07K14/71

CPC分类号： C07K14/7155 ,  C07K14/475 ,  C12N15/62 ,  A61P17/02 ,  C07K14/71 ,  C07K2319/33

摘要： The present invention provides a fusion protein comprising interleukin-1 receptor antagonist (IL-1Ra) and an extracellular matrix (ECM) binding peptide which specifically binds to one or more or all extracellular matrix proteins selected from the group consisting of fibrinogen, fibronectin, vitronectin, tenascin C and heparan sulfate and use of the fusion protein to treat conditions in which administration of IL-1Ra is beneficial or in which IL-1R1 signalling needs to be dampened, to enhance tissue regeneration, particularly bone regeneration and/or wound repair or for treating wounds, burns and muscle, cartilage, tendon and bone disorders, to enhance the regenerative activity of growth factor administration or to reduce inflammation or desensitisation of a cell to growth factor stimulation.

公开(公告)号：US11733233B2

公开(公告)日：2023-08-22

申请号：US16935097

申请日：2020-07-21

申请人： Celgene Corporation

发明人： Brian E. Cathers ,  Philip Chamberlain ,  Antonia Lopez-Girona ,  Gang Lu

IPC分类号： G01N33/50 ,  A61K38/00 ,  C07K14/47 ,  G16B30/00 ,  G01N33/566 ,  C07D401/04 ,  A61K31/4035 ,  C12N15/62 ,  G01N33/573 ,  A61K38/18

CPC分类号： G01N33/5008 ,  A61K31/4035 ,  A61K38/00 ,  C07D401/04 ,  C07K14/4702 ,  C12N15/62 ,  G01N33/566 ,  G01N33/573 ,  G16B30/00 ,  A61K38/18 ,  C07K2319/95 ,  C12Y203/02

摘要： Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.

公开(公告)号：US20230257425A1

公开(公告)日：2023-08-17

申请号：US17922407

申请日：2021-04-29

申请人： SK BIOSCIENCE CO., LTD.

发明人： Teawoo KWON ,  YoonJae LEE ,  Eun-som KIM ,  Seung-hye HONG ,  Ki-weon SEO ,  Sujeen LEE

IPC分类号： C07K14/165 ,  C07K14/33 ,  C12N15/62 ,  A61P31/14

CPC分类号： C07K14/165 ,  C07K14/33 ,  C12N15/62 ,  A61P31/14 ,  A61K2039/55505

摘要： Provided is a recombinant protein for preventing or treating infection of SARS-Coronavirus-2 antigen comprising an extended receptor binding domain (RBD) of a spike protein of SARS-Coronavirus-2, and a vaccine composition comprising thereof. Also the present invention relates to a method for preventing infection of SARS-Coronavirus-2 by administering the recombinant antigen protein to a subject. The present invention can prevent COVID-19 infection. The present invention can be used as a vaccine.

公开(公告)号：US11725060B2

公开(公告)日：2023-08-15

申请号：US16632144

申请日：2018-07-20

申请人： Aptevo Research and Development, LLC ,  Alligator Bioscience AB

发明人： David Bienvenue ,  Gabriela Hernandez-Hoyos ,  Lynda Misher ,  Danielle Van Citters ,  Peter Ellmark ,  Anna Sall ,  Christina Furebring ,  Laura von Schantz ,  Sara Fritzell ,  Laura Varas

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  C12N15/00 ,  C12N15/13 ,  C12N15/62 ,  A61P35/00 ,  A61K39/00 ,  A61K38/00 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/30 ,  A61P35/00 ,  C07K16/2878 ,  A61K38/00 ,  A61K39/395 ,  A61K2039/505 ,  A61K2039/5152 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94 ,  C12N5/10 ,  C12N15/62 ,  C12N15/63 ,  C12N2800/00

摘要： The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

公开(公告)号：US11718649B2

公开(公告)日：2023-08-08

申请号：US16754118

申请日：2018-10-11

申请人： HOSPITAL INFANTIL DE MÉXICO “FEDERICO GÓMEZ”

发明人： Juan Xicohtencatl Cortes ,  Victor Manuel Luna Pineda

IPC分类号： C07K14/245 ,  C07K1/14 ,  C12N15/62

CPC分类号： C07K14/245 ,  C07K1/14 ,  C12N15/62

摘要： The present invention is based on the fusion of FimH, CsgA and PapG adhesins (type 1 Fimbriae, curli and P, respectively) to generate biomolecules that can be used as vaccines against UTIs. Briefly, the invention is based on the design of a fusion template gene fimH-csgA-papG-fimH-csgA and defined as fcpfc to generate the different combinations of monomeric [FimH, CsgA and PapG], dimeric [FimH-CsgA (FC), CsgA-PapG (CP) and PapG-FimH (PF)] and trimeric (FimH-PapG-CsgA (FCP), PapG-CsgA-FimH (PCF) and CsgA-FimH-PapG (CFP)] proteins. Bioactivity was determined by the antibodies present in UP sera and urine, the quantification in the release of cytokines and adhesion inhibition assays.

公开(公告)号：US20230242923A1

公开(公告)日：2023-08-03

申请号：US18063629

申请日：2022-12-08

申请人： Modular Genetics, Inc.

发明人： Kevin A. Jarrell ,  Prashanth Vishwanath ,  Gabriel Oscar Reznik

IPC分类号： C12N15/62 ,  C12N15/82 ,  C12P13/02 ,  C12P13/04 ,  C12P13/14

CPC分类号： C12N15/62 ,  C12N15/8243 ,  C12N15/8251 ,  C12P13/02 ,  C12P13/04 ,  C12N15/8257 ,  C12P13/14 ,  Y10T436/174614

摘要： Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods at the present invention comprises cocoyl glutamate.

公开(公告)号：US20230242922A1

公开(公告)日：2023-08-03

申请号：US17931858

申请日：2022-09-13

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Jonathan CHESNUT ,  Alicia IHLAN ,  Robert POTTER ,  Youngzee SONG

IPC分类号： C12N15/62 ,  C12N15/90 ,  C12N9/22

CPC分类号： C12N15/62 ,  C12N15/907 ,  C12N9/22 ,  C07K2319/81

摘要： The present disclosure relates to recombinant nucleases, recombinant nucleases operatively linked to nucleic acid binding domains, and methods of making and using them.