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公开(公告)号：US20240042008A1
公开(公告)日：2024-02-08
申请号：US18034141
申请日：2021-10-27
发明人： Ki-weon SEO , Teawoo KWON , Eun-som KIM , Chi-Yong KIM , Yoonjae LEE , Seung-hye HONG
IPC分类号： A61K39/215 , A61P31/14 , C12N15/70 , C12N1/20 , C07K14/165
CPC分类号： A61K39/215 , A61P31/14 , C12N15/70 , C12N1/205 , C07K14/165 , A61K2039/55505
摘要： The present invention provides a recombinant antigen protein for preventing SARS-coronavirus-2 infection, comprising a polypeptide derived from an S1 subunit of a spike protein of SARS-coronavirus-2 and a polypeptide constituting a tetanus toxin (TT) epitope P2 domain, and a vaccine composition comprising the same.
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2.发明申请公开(公告)号：US20220073566A1
公开(公告)日：2022-03-10
申请号：US17290384
申请日：2019-11-01
发明人： Eun-som KIM , Teawoo KWON , Ki-weon SEO , Seung-hye HONG , Su Jeen LEE , Dong Soo HAM , Hun KIM
IPC分类号： C07K14/005 , A61P31/14 , A61K39/155
摘要： The present invention provides a respiratory syncytial virus (RSV) recombinant fusion protein (F protein) in which a polymerization domain derived from a foreign protein is bound to the C terminal of a fusion protein (F protein) lacking a transmembrane domain of a wild-type respiratory syncytial virus (RSV) fusion protein (F protein). The recombinant fusion protein of the present invention is soluble and can retain an F protein trimer. Excellent immune-inducing effects can be expected from the recombinant fusion protein of the present invention, and vaccine composition containing same.
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公开(公告)号：US20230257425A1
公开(公告)日：2023-08-17
申请号：US17922407
申请日：2021-04-29
发明人： Teawoo KWON , YoonJae LEE , Eun-som KIM , Seung-hye HONG , Ki-weon SEO , Sujeen LEE
IPC分类号： C07K14/165 , C07K14/33 , C12N15/62 , A61P31/14
CPC分类号： C07K14/165 , C07K14/33 , C12N15/62 , A61P31/14 , A61K2039/55505
摘要： Provided is a recombinant protein for preventing or treating infection of SARS-Coronavirus-2 antigen comprising an extended receptor binding domain (RBD) of a spike protein of SARS-Coronavirus-2, and a vaccine composition comprising thereof. Also the present invention relates to a method for preventing infection of SARS-Coronavirus-2 by administering the recombinant antigen protein to a subject. The present invention can prevent COVID-19 infection. The present invention can be used as a vaccine.
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公开(公告)号：US20220324917A1
公开(公告)日：2022-10-13
申请号：US17717504
申请日：2022-04-11
发明人： Ki-weon SEO , Eun-som KIM , Teawoo KWON
IPC分类号： C07K14/005 , C12N7/00 , A61P31/14 , A61K39/155
摘要： The present invention provides a recombinant attenuated respiratory syncytial virus (RSV) comprising F protein of stabilized pre-fusion RSV, or comprising protein consisting of the amino acid sequence represented by SEQ ID NO: 2 or functional fragment thereof, and provides genome of the recombinant RSV and a recombinant vector comprising the genome. The recombinant attenuated RSV can be provided as a live vaccine strain which maintains infectability and has excellent safety and stability.
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公开(公告)号：US20210355169A1
公开(公告)日：2021-11-18
申请号：US17283658
申请日：2019-10-14
发明人： Ki-weon SEO , Eun-som KIM , Teawoo KWON , Seung-hye HONG , Hun KIM , Su Jeen LEE
IPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , A61K39/155 , A61K39/165 , A61K39/17 , A61K39/295 , A61P31/14
摘要： The present invention provides a gene recombinant respiratory syncytial virus (RSV) in which genes encoding the envelope proteins of an RSV are rearranged, wherein in the RSV, a gene encoding the fusion protein (F protein) derived from a heterologous virus belonging to the family Paramyxoviridae or the family Pneumoviridae is inserted between the genes respectively encoding the glycoprotein (G protein) and the F protein of the RSV, or the gene encoding the F protein of the RSV is substituted with a gene encoding the F protein of a heterologous virus belonging to the family Paramyxoviridae or the family Pneumoviridae. The recombinant RSV of the present invention can be used as an RSV vaccine strain, and can be used as a vaccine due to having excellent stability and safety.
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