公开(公告)号：US08712522B1

公开(公告)日：2014-04-29

申请号：US11254042

申请日：2005-10-18

申请人： Martin A. Rossing

发明人： Martin A. Rossing

IPC分类号： A61N1/18

CPC分类号： A61N1/36139 ,  A61N1/08 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/37 ,  A61N1/37247

摘要： A real time, heart rate monitor and a hemodynamic monitoring system are operably integrated with the programmer system for an implantable hypertension treatment device. A series of tests are automatically performed to set programmable parameters for the implantable hypertension treatment device without clinician intervention. In one embodiment, a predetermined level of a dose-response evaluation is initiated for each test in the series. Preferably, the programmer system monitors the heart rate to determine whether a hemodynamic measurement should be initiated at all for a given test, as well as whether the hemodynamic measurement should be initiated earlier or later than a predetermined settling period for assessing the sympathetic nervous response to the test dose. In one embodiment, this determination is based on heart rate stability/instability. Alternatively, other indicators of sympathetic/parasympathetic tone, such as heart rate variability, may be used to trigger/delay the timing of the hemodynamic measurement.

摘要翻译： 实时心率监测器和血液动力学监测系统可与编程器系统可操作地集成用于可植入的高血压治疗装置。 自动进行一系列测试，以设置可植入性高血压治疗装置的可编程参数，无需临床医生干预。 在一个实施例中，针对该系列中的每个测试启动预定水平的剂量 - 响应评估。 优选地，程序员系统监测心率以确定对于给定的测试是否应该开始血液动力学测量，以及是否应该早于或晚于预定的沉降周期开始血液动力学测量，以评估对于 测试剂量。 在一个实施例中，该确定基于心率稳定性/不稳定性。 或者，可以使用交感神经/副交感神经张力的其它指标，例如心率变异性来触发/延迟血液动力学测量的时间。

公开(公告)号：US08706236B2

公开(公告)日：2014-04-22

申请号：US13850235

申请日：2013-03-25

申请人： Synapse Biomedical, Inc.

发明人： Anthony R. Ignagni ,  Raymond P. Onders

IPC分类号： A61N1/18

CPC分类号： A61N1/3601 ,  A61N1/0558 ,  A61N1/3611

摘要： A method of conditioning a diaphragm of a patient is provided. The method can include the steps of implanting an electrode adjacent a target site in the diaphragm of the patient and operating the electrode to deliver a sufficient amount of electrical stimulation to the target site in the diaphragm of the patient to cause the diaphragm to contract.

摘要翻译： 提供了调节患者的隔膜的方法。 该方法可以包括以下步骤：将邻近目标部位的电极植入患者的隔膜中，并操作电极，以向患者的隔膜中的目标部位输送足够量的电刺激，以使隔膜收缩。

公开(公告)号：US08630711B1

公开(公告)日：2014-01-14

申请号：US12572866

申请日：2009-10-02

申请人： Heather A. C. Wark ,  Patrick C. Cartwright ,  Richard A. Normann

发明人： Heather A. C. Wark ,  Patrick C. Cartwright ,  Richard A. Normann

IPC分类号： A61N1/18

CPC分类号： A61N1/0551 ,  A61N1/36007 ,  A61N1/36057 ,  A61N1/36107 ,  A61N1/36171

摘要： Methods and related systems for treating patients suffering from several disorders including bladder dysfunction, erectile dysfunction, and bowel elimination disorders are disclosed and described. The method can include identification of the disorder followed by the step of accessing a pudendal nerve of the patient. A microelectrode array having a plurality of electrodes thereon is inserted into the pudendal nerve of the patient. A controller is electronically associated with the microelectrode array which is programmed to provide selective activation and/or blocking of various muscles using the microelectrodes of the array. The selective stimulation can be tuned to selectively activate or block at least one muscle selected from the group consisting of the external urethral sphincter, the detrusor muscle, the anal sphincter, and the cavernous smooth musculature of the penis.

摘要翻译： 公开和描述了用于治疗患有几种疾病（包括膀胱功能障碍，勃起功能障碍和排便障碍）的患者的方法和相关系统。 该方法可以包括识别疾病，随后进入患者的阴部神经的步骤。 将具有多个电极的微电极阵列插入到患者的阴部神经中。 控制器与微电极阵列电子相关联，微电极阵列被编程为使用阵列的微电极提供各种肌肉的选择性活化和/或阻断。 可以调节选择性刺激以选择性地激活或阻断选自由外部尿道括约肌，逼尿肌，肛门括约肌和阴茎海绵状平滑肌肉组成的组中的至少一种肌肉。

公开(公告)号：US08630706B2

公开(公告)日：2014-01-14

申请号：US13385923

申请日：2012-03-13

申请人： Ralph G. Dacey, Jr. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

发明人： Ralph G. Dacey, Jr. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

IPC分类号： A61N1/18

CPC分类号： A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

摘要： Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

摘要翻译： 公开了通过用化学阻断剂重复地阻断外周神经结构传导来调节神经活动的方法和相关系统。 还公开了用于逆转化学阻断剂的作用和/或用于产生基本上永久的传导阻滞的方法和系统。

公开(公告)号：US08620442B2

公开(公告)日：2013-12-31

申请号：US13014968

申请日：2011-01-27

申请人： Alan Matthew Horsager ,  Geoffrey M. Boynton ,  Ione Fine ,  Robert J. Greenberg

发明人： Alan Matthew Horsager ,  Geoffrey M. Boynton ,  Ione Fine ,  Robert J. Greenberg

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： The present invention is a method of stimulating visual neurons to create the perception of light. A visual prosthesis electrically stimulating the retina with implanted electrodes exhibits interaction between electrodes stimulated closely together in both space and time. The method of the present invention includes determining a minimum distance at which spatiotemporal interactions occur, determining a minimum time at which spatiotemporal interactions occur, and avoiding stimulation of electrodes within the minimum distance during the minimum time. The minimum are ideally established for each individual patient. Alternatively, approximate minimums have been established by the applicants at 2 mm and 1.8 μsec.

摘要翻译： 本发明是一种刺激视觉神经元以产生光的感知的方法。 用植入电极电刺激视网膜的视觉假体显示出在空间和时间上紧密刺激的电极之间的相互作用。 本发明的方法包括确定发生时空相互作用的最小距离，确定发生时空相互作用的最小时间，并避免在最小时间内在最小距离内刺激电极。 理想地为每个患者确定最小值。 或者，申请人已经建立了2毫米和1.8个小时的大概最小值。

公开(公告)号：US08620439B2

公开(公告)日：2013-12-31

申请号：US12379935

申请日：2009-03-04

申请人： Jeong-hwan Lee ,  Kun-soo Shin ,  Wan-taek Han ,  Hyung-sok Yeo ,  Jin-sang Whang

发明人： Jeong-hwan Lee ,  Kun-soo Shin ,  Wan-taek Han ,  Hyung-sok Yeo ,  Jin-sang Whang

IPC分类号： A61N1/18

CPC分类号： A61N1/36014 ,  A61B5/0245 ,  A61B5/0488 ,  A61B5/11 ,  A61N1/36003 ,  A63B2213/004 ,  A63B2230/06

摘要： An apparatus, method, and medium for generating electrical stimulation, including an electromyogram detector detecting an electromyographic signal of a body, a fatigue index calculator calculating a fatigue index indicating a degree of muscle fatigue by converting the electromyographic signal detected by the electromyogram detector during a predetermined time unit into a frequency-domain electromyographic signal, and an electrical stimulation signal generator adjusting an electrical stimulation signal according to the calculated fatigue index and generating the electrical stimulation signal. Accordingly, a health training/monitoring apparatus can include an electrical stimulation generator adjusting an electrical stimulation signal according to a degree of fatigue and generating the electrical stimulation signal, a physical activity monitor monitoring a physical activity using at least one of a heart rate measurer and an accelerometer, and a mode selector selectively driving the electrical stimulation generator or the physical activity monitor according to an amount of the physical activity.

公开(公告)号：US08612006B2

公开(公告)日：2013-12-17

申请号：US11303292

申请日：2005-12-16

申请人： Andres M. Lozano ,  Hiroki Toda

发明人： Andres M. Lozano ,  Hiroki Toda

IPC分类号： A61N1/18

CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M2210/0693 ,  A61N1/06 ,  A61N1/36082 ,  A61N1/36096

摘要： Methods and apparatus for inducing neurogenesis within a human. An implantable signal generator is used to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.

摘要翻译： 用于诱导人类神经发生的方法和装置。 可植入信号发生器用于向深部脑组织元件传递高频刺激。 植入的装置向大脑递送治疗疗法，从而诱导人的神经发生。 传感器可用于检测神经系统发现的各种症状。 然后，微处理器算法可以分析来自传感器的输出，以调节传递给大脑的刺激和/或药物治疗。

公开(公告)号：US08594809B2

公开(公告)日：2013-11-26

申请号：US12414384

申请日：2009-03-30

申请人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

发明人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

IPC分类号： A61N1/18

CPC分类号： A61N1/05

摘要： An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupled to the distal end of the lead body. A linking material is coupled to the first surface of the support member. A bioadhesive material is coupled to the linking material. A removable cover is placed over the bioadhesive material.

摘要翻译： 公开了可植入的被动固定引线。 被动固定引线包括具有至少一个细长导电元件的细长引线体。 引线体包括近端和远端。 支撑构件具有第一表面和第二表面。 第二表面联接到引线主体的远端。 连接材料联接到支撑构件的第一表面。 生物粘附材料与连接材料连接。 可移除的盖子放置在生物粘附材料上。

公开(公告)号：US08588931B2

公开(公告)日：2013-11-19

申请号：US12885174

申请日：2010-09-17

申请人： Mark Edward Halpern ,  James Bernard Fallon

发明人： Mark Edward Halpern ,  James Bernard Fallon

IPC分类号： A61N1/18

CPC分类号： A61N1/37 ,  A61N1/3716

摘要： Neural stimulation is effected by a stimulus current pulse. The current pulse is initially of an amplitude to rapidly induce a desired electrode voltage, and is subsequently of reduced amplitude to control electrode voltage in a desired manner. This can effect a reduced peak electrode voltage while delivering a given amount of charge. Optimization of the current pulse may further involve parameterising an electrode current waveform as a sequence of piecewise constant steps, each step having substantially the same duration as all other steps and each step having a calculatable amplitude, and identifying electrode-tissue interface (ETI) parameters. For each step of the pulse, the respective step amplitude is then calculated using the identified ETI parameters to optimise the electrode voltage.

摘要翻译： 刺激电流脉冲影响神经刺激。 电流脉冲最初是振幅以迅速地引起期望的电极电压，并且随后减小幅度以期望的方式控制电极电压。 这可以在递送给定量的电荷的同时实现降低的峰值电极电压。 当前脉冲的优化还可以包括将电极电流波形参数化为分段常数步骤序列，每个步骤具有与所有其它步骤基本上相同的持续时间，并且每个步骤具有可计算振幅，并且识别电极 - 组织界面（ETI）参数 。 对于脉冲的每个步骤，然后使用所识别的ETI参数来计算各个步幅，以优化电极电压。

公开(公告)号：US08583241B2

公开(公告)日：2013-11-12

申请号：US12023907

申请日：2008-01-31

申请人： Robert J. Greenberg ,  Arup Roy ,  Avraham I. Caspi ,  Matthew J. McMahon

发明人： Robert J. Greenberg ,  Arup Roy ,  Avraham I. Caspi ,  Matthew J. McMahon

IPC分类号： A61N1/18

CPC分类号： A61N1/36046 ,  A61B3/1005 ,  A61B5/4836 ,  A61N1/0543

摘要： A visual prosthesis apparatus including a video capture device for capturing a video image, a video processing unit associated with the video capture device, the video processing unit configured to convert the video image to stimulation patterns, and a stimulation system configured to stimulate subject's neural tissue based on the stimulation patterns, wherein the stimulation system provides a span of visual angle matched to the subject's neural tissue being stimulated.