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公开(公告)号：US08583236B2
公开(公告)日：2013-11-12
申请号：US12719696
申请日：2010-03-08
IPC分类号： A61N1/04
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. An intravascularly implantable medical device may include a sleeve formed at least in part of an expandable member configured to be movably attachable about at least a portion of an outer surface of an expandable intravascular stent, and one or more electrodes disposed on the sleeve and coupled to a control system and configured to selectively activate baroreceptors within a wall of a vessel when the expandable intravascular stent is implanted within the vessel.
摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 血管内可植入医疗装置可以包括至少部分可扩张构件形成的套筒，所述可扩张构件构造成围绕可膨胀血管内支架的外表面的至少一部分可移动地附接，以及一个或多个设置在套筒上并连接到 控制系统，并且被配置为当可扩张血管内支架植入血管内时选择性地激活血管壁内的压力感受器。
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公开(公告)号：US08224437B2
公开(公告)日：2012-07-17
申请号：US12245636
申请日：2008-10-03
CPC分类号： A61N1/08 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
摘要翻译： 系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。 方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。 系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活 压力反射激活装置。 在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。
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3.发明申请公开(公告)号：US20100222831A1
公开(公告)日：2010-09-02
申请号：US12762891
申请日：2010-04-19
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压力感受器激活装置可以利用电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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公开(公告)号：US20090198294A1
公开(公告)日：2009-08-06
申请号：US12422147
申请日：2009-04-10
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Devices, systems and methods provide baroreflex activation to prevent, or at least reduce the likelihood of occurrence of, cardiac arrhythmias. Various embodiments may additionally or alternatively promote recovery from arrhythmias. In one embodiment, a device for preventing or reducing the likelihood of occurrence of arrhythmias includes one or more baroreflex activation devices, one or more sensors coupled to the baroreflex activation device(s), and a processor for processing information from the sensor and activating and/or modulation the baroreflex activation device. Sensors, such as electrocardiogram devices, generally sense factors indicative of a potential, ensuing arrhythmia.
摘要翻译： 装置，系统和方法提供压力反射激活以防止或至少降低发生心律失常的可能性。 各种实施方案可以额外地或替代地促进从心律失常的恢复。 在一个实施例中，用于防止或减少发生心律失常的可能性的装置包括一个或多个压力反射激活装置，耦合到压力反射激活装置的一个或多个传感器，以及用于处理来自传感器的信息的处理器， /或调制压力反射激活装置。 传感器，例如心电图设备，通常感测指示潜在的随之而来的心律失常的因子。
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5.发明申请公开(公告)号：US20090069738A1
公开(公告)日：2009-03-12
申请号：US12174428
申请日：2008-07-16
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/056 , A61N1/306
摘要： Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.
摘要翻译： 用于植入的电极结构包括电极，附着到电极的弹性背衬和背衬或电极上的螯合药物，其被释放以控制和/或限制瘢痕组织的生长。 弹性背衬包括接触组织结构的组织接触侧和远离组织接触侧的暴露侧。 电极结构可用于激活压力感受器，并且背衬是弹性的并且可以与组织结构例如颈动脉窦一起伸展和缩回。 电极和螯合药物可以定位在组织接触侧，因此药物在电极附近释放。 背衬可以由绝缘材料制成并且限制药物朝向暴露侧的扩散，允许瘢痕组织在暴露侧附近生长以保持电极的定位。
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公开(公告)号：US20080172101A1
公开(公告)日：2008-07-17
申请号：US11933283
申请日：2007-10-31
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/05 , A61N1/08 , A61N1/36117 , A61N1/36185
摘要： A system for stimulation, including an implantable pulse generator, a lead comprising an array body disposed at a distal end of the lead and a plurality of electrodes concentrically arranged on the array body, and a plurality of conductors, wherein one of the conductors is attached to each electrode and wherein the conductors are configured and arranged to couple the electrodes to the implantable pulse generator.
摘要翻译： 一种用于刺激的系统，包括可植入脉冲发生器，包括设置在引线的远端的阵列体的引线和同心地布置在阵列体上的多个电极，以及多个导体，其中一个导体被附接 并且其中所述导体被配置和布置成将所述电极耦合到所述可植入脉冲发生器。
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公开(公告)号：US20080167696A1
公开(公告)日：2008-07-10
申请号：US11963357
申请日：2007-12-21
申请人： Adam W. Cates , Martin A. Rossing
发明人： Adam W. Cates , Martin A. Rossing
IPC分类号： A61N1/18
CPC分类号： A61N1/0556 , A61N1/36114 , A61N1/36117
摘要： A method and apparatus for stimulation of a baroreflex system of a patient is provided. A method comprises establishing a therapy regimen including at least one pulse which includes at least two phases. Each phase has a polarity which is different than that of the other phase. The baroreflex system of the patient is activated with at least one baroreflex activation device which is responsive to the therapy regimen.
摘要翻译： 提供了用于刺激患者的压力反射系统的方法和装置。 一种方法包括建立包括至少一个包括至少两个相的脉冲的治疗方案。 每相具有与另一相不同的极性。 患者的压力反射系统通过响应于治疗方案的至少一个压力反射激活装置来激活。
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公开(公告)号：US4263915A
公开(公告)日：1981-04-28
申请号：US957954
申请日：1978-11-06
申请人： Ray S. McDonald , Martin A. Rossing
发明人： Ray S. McDonald , Martin A. Rossing
CPC分类号： A61N1/37211 , A61N1/365 , A61N1/37252
摘要： A programmable cardiac pacemaker pulse generator utilizing digital circuitry for controlling the provision of cardiac stimulating pulses. The pulse generator is capable of having the rate, the pulse width, the pulse amplitude, the refractory period, the sensitivity and the mode of operation programmed. In addition, the pulse generator can have the output inhibited and can respond to programming signals causing a threshold margin test to be performed, effects of closure of the reed switch overridden, a hysteresis function added and a high rate exceeding the normal upper rate limit programmed. Many of the programmable functions of the pulse generator can either be programmed on a permanent or a temporary basis. The pulse generator further includes means for signalling the acceptance of a programming signal, and means to reset the program acceptance circuit if extraneous signals are detected as programming signals. The program signal acceptance circuit performs several different checks on the detected programming signal including a parity check, an access code check and determining if the proper number of signals were transmitted within a given time. The timing circuit of the pulse generator includes a crystal clock oscillator and counter means for counting the clock pulses therefrom to determine the rate of the pacemaker. The pulse width of each pacemaker pulse is determined by using a volage controlled oscillator in place of the crystal oscillator to obtain energy compensation due to the battery voltage decreasing with time.
摘要翻译： 一种可编程心脏起搏器脉冲发生器，利用数字电路来控制提供心脏刺激脉冲。 脉冲发生器能够具有速率，脉冲宽度，脉冲幅度，不应期，灵敏度和编程方式。 此外，脉冲发生器可以禁止输出并且可以对编程信号做出响应，导致执行阈值余量测试，切换簧片开关的闭合效应，添加的滞后函数以及超过常规上限速率限制的高速率 。 脉冲发生器的许多可编程功能可以被永久地或临时地编程。 脉冲发生器还包括用于发信号通知编程信号的装置，以及如果外部信号被检测为编程信号则复位程序接受电路的装置。 程序信号接收电路对检测到的编程信号执行若干不同的检查，包括奇偶校验，访问码检查和确定在给定时间内是否传送了适当数量的信号。 脉冲发生器的定时电路包括晶体时钟振荡器和用于从其计数时钟脉冲的计数器装置，以确定起搏器的速率。 每个起搏器脉冲的脉冲宽度是通过使用压控振荡器代替晶体振荡器来确定的，由于电池电压随时间的推移而获得能量补偿。
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公开(公告)号：US08718789B2
公开(公告)日：2014-05-06
申请号：US12762891
申请日：2010-04-19
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
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10.发明授权Devices and methods for cardiovascular reflex control via coupled electrodes 有权通过耦合电极进行心血管反射控制的装置和方法公开(公告)号：US07949400B2
公开(公告)日：2011-05-24
申请号：US12616057
申请日：2009-11-10
IPC分类号： A61N1/05
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译： 公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。 压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。 控制系统可用于调节压力感受器激活装置。 控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。 压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。 电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。
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