公开(公告)号：US08009287B2

公开(公告)日：2011-08-30

申请号：US11721832

申请日：2005-12-15

Applicant: Bernd Abel ,  Jürgen Troe ,  Ales Charvat

Inventor： Bernd Abel ,  Jürgen Troe ,  Ales Charvat

IPC: G01N1/10

CPC classification number: H01J49/161 ,  H01J49/04

Abstract: The invention relates to a test method, especially for mass spectroscopy of biomolecules, including the following steps: one or several samples (2-4) that are to be analyzed are introduced into a carrier liquid of a micro liquid jet (1) in rapid succession; at least some of the samples (2-4) are desorbed from the micro liquid jet (1); and the sample (2-4) that is desorbed from the micro liquid jet (1) is analyzed. According to the invention, the sample (2-4) is spatially delimited in the spraying direction in the micro liquid jet (1) while extending only along a subarea of the micro liquid jet (1) in the spraying direction.

Abstract translation: 本发明涉及一种特别用于生物分子的质谱法的测试方法，其包括以下步骤：将要分析的一种或几种样品（2-4）快速引入微液体射流（1）的载体液体中 演替; 至少一些样品（2-4）从微液体射流（1）中解吸; 并且分析从微液体射流（1）解吸的样品（2-4）。 根据本发明，样品（2-4）在微液体射流（1）中在喷射方向上在空间上被界定，同时沿着喷雾方向的微液体射流（1）的分区延伸。

公开(公告)号：US07414241B2

公开(公告)日：2008-08-19

申请号：US11294714

申请日：2005-12-05

Applicant: Jill R. Scott ,  Paul L. Tremblay

Inventor： Jill R. Scott ,  Paul L. Tremblay

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/161

Abstract: A laser device includes a virtual source configured to aim laser energy that originates from a true source. The virtual source has a vertical rotational axis during vertical motion of the virtual source and the vertical axis passes through an exit point from which the laser energy emanates independent of virtual source position. The emanating laser energy is collinear with an orientation line. The laser device includes a virtual source manipulation mechanism that positions the virtual source. The manipulation mechanism has a center of lateral pivot approximately coincident with a lateral index and a center of vertical pivot approximately coincident with a vertical index. The vertical index and lateral index intersect at an index origin. The virtual source and manipulation mechanism auto align the orientation line through the index origin during virtual source motion.

Abstract translation: 激光设备包括被配置为瞄准源自真实源的激光能量的虚拟源。 虚拟源在虚拟源的垂直运动期间具有垂直旋转轴，并且垂直轴穿过激光能量独立于虚拟源位置从该出口点出射。 发射激光能量与取向线共线。 激光装置包括定位虚拟源的虚拟源操纵机构。 操纵机构具有大致与横向索引大致一致的横向枢轴的中心，垂直枢轴的中心大致与竖直索引重合。 垂直指数和横向指数在指数起点处相交。 虚拟源和操纵机构在虚拟源运动期间自动对准通过索引原点的方向线。

公开(公告)号：US20070114388A1

公开(公告)日：2007-05-24

申请号：US11590802

申请日：2006-11-01

Applicant: Kiyoshi Ogawa ,  Sadao Takeuchi ,  Takahiro Harada ,  Yoshihiro Ueno ,  Fujio Inoue ,  Mitsutoshi Setou

Inventor： Kiyoshi Ogawa ,  Sadao Takeuchi ,  Takahiro Harada ,  Yoshihiro Ueno ,  Fujio Inoue ,  Mitsutoshi Setou

IPC: H01J49/00

CPC classification number: H01J49/161 ,  H01J49/0004

Abstract: An imaging mass spectrometer, an image of a sample is generated, and a region in the image is selected in accordance with predetermined criteria. Then, a mass analysis of the region is performed while scanning the sample in the selected region with a laser beam spot. By computing the total or average of the results in the region, a high precision analytical value in the region can be obtained. In a biological sample, by preliminarily performing a staining process on the biological sample using a certain dye, only the objective tissues can be analyzed. Also, a fluorescence microscope can be used.

Abstract translation: 产生成像质谱仪，样品的图像，并且根据预定标准选择图像中的区域。 然后，利用激光束点扫描所选择的区域中的样品，进行该区域的质量分析。 通过计算该区域的结果的总体或平均值，可以获得该区域的高精度分析值。 在生物样品中，通过使用某种染料预先对生物样品进行染色处理，只能分析目标组织。 此外，可以使用荧光显微镜。

公开(公告)号：US06809318B2

公开(公告)日：2004-10-26

申请号：US10657580

申请日：2003-09-08

Applicant: Andrew Krutchinsky ,  Herbert Cohen ,  Markus Kalkum ,  Vadim Sherman ,  Brian Chait

Inventor： Andrew Krutchinsky ,  Herbert Cohen ,  Markus Kalkum ,  Vadim Sherman ,  Brian Chait

IPC: B01D5944

CPC classification number: H01J49/063 ,  H01J49/0481 ,  H01J49/161 ,  H01J49/164

Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

公开(公告)号：US06784423B2

公开(公告)日：2004-08-31

申请号：US10251352

申请日：2002-09-20

Applicant: William David Reents, Jr. ,  Michael J Schabel

Inventor： William David Reents, Jr. ,  Michael J Schabel

IPC: H01J4900

CPC classification number: H01J49/161 ,  H01J49/40

Abstract: A method for determining the shape and size of particles and their constituent elements is disclosed. Particle ions are accelerated through a mass spectrometer useful in identifying the source particle of the resulting ions. By measuring the time-varying intensity of the identified ions as they strike a detector, a plot of the intensity of the ions over time is obtained for each ionized particle. The size of each ionized particle is determined by measuring a time span corresponding to the width of the peak of this plot. If the detector is a phosphor detector, the shape of the particle may be determined by using a high-speed camera to capture cross-section images of the ion-induced light pattern at closely-spaced successive moments in time. Alternatively, the intensity of ions striking the detector along at least one lateral dimension may be detected. By combining the multiple cross section images or the multiple lateral direction intensity profiles that are thus captured, an actual image of the shape of the original particle can be obtained.

Abstract translation: 公开了一种用于确定颗粒及其构成元件的形状和尺寸的方法。 通过可用于鉴定所得离子的源粒子的质谱仪加速粒子离子。 通过测量所鉴定的离子随着检测器的时变强度，每个电离粒子获得离子强度随时间的变化图。 通过测量对应于该图的峰的宽度的时间跨度来确定每个电离粒子的尺寸。 如果检测器是磷光体检测器，则可以通过使用高速摄像机来确定颗粒的形状，以在紧密间隔的连续时刻捕获离子诱导的光图案的横截面图像。 或者，可以检测沿着至少一个横向尺寸撞击检测器的离子的强度。 通过组合由此捕获的多个横截面图像或多个横向强度分布，可以获得原始粒子的形状的实际图像。

公开(公告)号：US06734423B2

公开(公告)日：2004-05-11

申请号：US10030396

申请日：2002-01-08

Applicant: Wayne A. Bryden

Inventor： Wayne A. Bryden

IPC: H01J4910

CPC classification number: H01J49/0022 ,  H01J49/161

Abstract: A mass spectrometer system comprising a laser and a mass spectrometer. The mass spectrometer has a vacuum interface that provides entrance of a gaseous sample into an extraction region of the mass spectrometer. The laser is positioned to provide laser light incident on a sample non-gaseous substance positioned adjacent the vacuum interface. The laser light provides vaporization of the sample, which provides a high concentration of gaseous molecules from the sample substance at the vacuum interface.

Abstract translation: 包括激光和质谱仪的质谱仪系统。 质谱仪具有真空界面，其提供气体样品进入质谱仪的提取区域。 激光被定位成提供入射在邻近真空界面定位的样品非气态物质上的激光。 激光提供样品的蒸发，其在真空界面处从样品物质提供高浓度的气体分子。

公开(公告)号：US20030006369A1

公开(公告)日：2003-01-09

申请号：US10030396

申请日：2002-01-08

Inventor： Wayne A. Bryden

IPC: H01J049/00

CPC classification number: H01J49/0022 ,  H01J49/161

Abstract: A mass spectrometer system comprising a laser and a mass spectrometer. The mass spectrometer has a vacuum interface that provides entrance of a gaseous sample into an extraction region of the mass spectrometer. The laser is positioned to provide laser light incident on a sample non-gaseous substance positioned adjacent the vacuum interface. The laser light provides vaporization of the sample, which provides a high concentration of gaseous molecules from the sample substance at the vacuum interface.

Abstract translation: 包括激光和质谱仪的质谱仪系统。 质谱仪具有真空界面，其提供气体样品进入质谱仪的提取区域。 激光被定位成提供入射在邻近真空界面定位的样品非气态物质上的激光。 激光提供样品的蒸发，其在真空界面处从样品物质提供高浓度的气体分子。

公开(公告)号：US4889987A

公开(公告)日：1989-12-26

申请号：US14332

申请日：1987-02-13

Applicant: Dieter M. Gruen ,  Charles E. Young ,  Michael J. Pellin

Inventor： Dieter M. Gruen ,  Charles E. Young ,  Michael J. Pellin

IPC: H01J49/02 ,  H01J49/06 ,  H01J49/14 ,  H01J49/16 ,  H01J49/28

CPC classification number: H01J49/161 ,  H01J49/022 ,  H01J49/061 ,  H01J49/142 ,  H01J49/282 ,  H01J49/484

Abstract: A charged particle spectrometer for performing ultrasensitive quantitative analysis of selected atomic components removed from a sample. Significant improvements in performing energy and angular refocusing spectroscopy are accomplished by means of a two dimensional structure for generating predetermined electromagnetic field boundary conditions. Both resonance and non-resonance ionization of selected neutral atomic components allow accumulation of increased chemical information. A multiplexed operation between a SIMS mode and a neutral atomic component ionization mode with EARTOF analysis enables comparison of chemical information from secondary ions and neutral atomic components removed from the sample. An electronic system is described for switching high level signals, such as SIMS signals, directly to a transient recorder and through a charge amplifier to the transient recorder for a low level signal pulse counting mode, such as for a neutral atomic component ionization mode.

Abstract translation: 一种带电粒子光谱仪，用于对从样品中除去的选定的原子成分进行超敏感定量分析。 通过用于产生预定电磁场边界条件的二维结构来实现执行能量和角度重新聚焦光谱的显着改进。 所选择的中性原子组分的共振和非共振电离都允许累积增加的化学信息。 通过EARTOF分析，SIMS模式和中性原子成分离子化模式之间的多路复用操作能够比较从样品中除去的二次离子和中性原子成分的化学信息。 描述了一种电子系统，用于将高电平信号（例如SIMS信号）直接切换到瞬态记录器，并通过电荷放大器切换到瞬态记录器，用于低电平信号脉冲计数模式，例如用于中性原子分量电离模式。

公开(公告)号：US4864130A

公开(公告)日：1989-09-05

申请号：US870437

申请日：1986-06-04

Applicant: Dieter M. Gruen ,  Charles E. Young ,  Michael J. Pellin

Inventor： Dieter M. Gruen ,  Charles E. Young ,  Michael J. Pellin

IPC: H01J37/08 ,  G01Q30/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/26 ,  H01J49/28

CPC classification number: H01J49/484 ,  H01J49/061 ,  H01J49/142 ,  H01J49/161 ,  H01J49/282

Abstract: A method and apparatus for extracting for quantitative analysis ions of selected atomic components of a sample. A lens system is configured to provide a slowly diminishing field region for a volume containing the selected atomic components, enabling accurate energy analysis of ions generated in the slowly diminishing field region. The lens system also enables focusing on a sample of a charged particle beam, such as an ion beam, along a path length perpendicular to the sample and extraction of the charged particles along a path length also perpendicular to the sample. Improvement of signal to noise ratio is achieved by laser excitation of ions to selected autoionization states before carrying out quantitative analysis. Accurate energy analysis of energetic charged particles is assured by using a preselected resistive thick film configuration disposed on an insulator substrate for generating predetermined electric field boundary conditions to achieve for analysis the required electric field potential. The spectrometer also is applicable in the fields of SIMS, ISS and electron spectroscopy.

公开(公告)号：US4293769A

公开(公告)日：1981-10-06

申请号：US94959

申请日：1979-11-16

Applicant: Daniel Kleppner

Inventor： Daniel Kleppner

IPC: G01J1/00 ,  H01J49/16

CPC classification number: H01J49/168 ,  G01J1/00 ,  H01J49/161

Abstract: An atomic beam is excited by laser radiation to a state with large principal quantum number. The beam is irradiated with infrared or millimeter wave radiation which is to be detected. The atoms absorb the radiation by making transitions to higher-lying states. The transitions are sensed by applying an electric field which ionizes atoms in the final state, but not the initial state. The ions ae collected and detected by conventional pulse-counting or direct current methods.

Abstract translation: 原子束被激光辐射激发到具有较大主量子数的状态。 用要检测的红外线或毫米波辐射照射光束。 原子通过向更高的状态转变来吸收辐射。 通过施加在最终状态下电离原子但不是初始状态的电场来感测转变。 通过常规脉冲计数或直流方法收集和检测离子。