公开(公告)号：US20040251423A1

公开(公告)日：2004-12-16

申请号：US10811494

申请日：2004-03-26

申请人： JEOL Ltd.

发明人： Eiji Kawai

IPC分类号： H01J049/00

CPC分类号： H01J37/141 ,  H01J9/236 ,  Y10S430/143

摘要： A method of efficiently fabricating a multipole lens. The multipole lens has plural polar elements and an annular holding member. Each polar element has a held portion. The annular holding member is provided with through-holes for holding the held portions of the polar elements. A resin is injected into the through-holes in the holding member via openings formed in the holding member, the openings being in communication with the through-holes. The injected resin is cured, thus holding the held portions of the polar elements to the holding member within the through-holes.

摘要翻译： 一种有效地制造多极镜的方法。 多极透镜具有多个极性元件和环形保持构件。 每个极性元件具有保持部分。 环形保持构件设置有用于保持极性元件的保持部分的通孔。 通过形成在保持构件中的开口将树脂注入到保持构件的通孔中，开口与通孔连通。 注入的树脂被固化，从而将极性元件的保持部分保持在通孔内的保持构件。

公开(公告)号：US20040251408A1

公开(公告)日：2004-12-16

申请号：US10813166

申请日：2004-03-31

申请人： ANELVA Corporation

发明人： Yoshiki Hirano ,  Yoshiro Shiokawa ,  Harumi Maruyama ,  Megumi Nakamura

IPC分类号： H01J049/00

CPC分类号： H01J49/04 ,  H01J49/10

摘要： An ion attachment mass spectrometry apparatus causing positively charged metal ions to attach to molecules of a gas to be measured in an attachment region to generate attached ions and then performing mass spectrometry on the attached ions by a mass spectrometer, has a metal ion selective disassociation unit for selectively making the metal ions attached to the specific molecules in the attachment region disassociate. By making the metal ions attached to the specific molecules such as H2O disassociate, a state is formed where the metal ions are attached to only the sample gas to be measured and the reliability of measurement of the gas is improved.

摘要翻译： 使带正电荷的金属离子附着在附着区域中被测量气体的分子以产生附着离子，然后通过质谱仪对附着的离子进行质谱分析的离子附着质谱仪具有金属离子选择性分离单元 用于选择性地使连接到附着区域中的特定分子的金属离子脱离。 通过使金属离子附着于特定分子如H 2脱离，形成其中金属离子仅附着到待测样品气体并提高气体测量可靠性的状态。

公开(公告)号：US20040241834A1

公开(公告)日：2004-12-02

申请号：US10485718

申请日：2004-01-30

发明人： Peter James

IPC分类号： C12M001/34 ,  H01J049/00

CPC分类号： G01N33/6848 ,  B01J2219/00317 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00725 ,  G01N27/4473 ,  G01N33/6851 ,  G01N2001/4038 ,  H01J49/0418

摘要： The invention relates to a device for protein and/or peptide concentration, which device comprises electroconcentration means (23); at least two electrodes having a positive (7) and a negative charge (35), respectively; and protein and/or peptide capture means (17); wherein said electroconcentration means (23) comprises a funnel shaped cavity and at least one electrode is located on each side of the electroconcentration means. The invention also relates to a method for concentrating a protein and/or a peptide in a sample, which method can be performed in a device according to the invention.

摘要翻译： 本发明涉及一种用于蛋白质和/或肽浓度的装置，该装置包括电气浓缩装置（23）; 分别具有正（7）和负电荷（35）的至少两个电极; 和蛋白质和/或肽捕捉装置（17）; 其中所述电气浓缩装置（23）包括漏斗形空腔，并且至少一个电极位于电气浓缩装置的每一侧。 本发明还涉及将样品中的蛋白质和/或肽浓缩的方法，该方法可以在根据本发明的装置中进行。

公开(公告)号：US20040238732A1

公开(公告)日：2004-12-02

申请号：US10492582

申请日：2004-07-15

发明人： Andrei State ,  Kurtis P Keller ,  Jeremy D Ackerman ,  Henry Fuchs

IPC分类号： H01J049/00

CPC分类号： A61B90/36 ,  A61B10/0233 ,  A61B90/361 ,  A61B2090/371 ,  G02B27/017 ,  G02B2027/0127 ,  G02B2027/0129 ,  G02B2027/0138 ,  G02B2027/014 ,  G02B2027/0187 ,  H04N13/128 ,  H04N13/344 ,  H04N13/398

摘要： Methods and systems for dynamic virtual convergence (218) and a video see through head mountable display (200) that uses dynamic virtual convergence are disclosed. A dynamic virtual convergence algorithm (218) includes sampling an image with two cameras. The cameras each have a field of view that is larger than a field of view of displays used to display images sampled by the cameras (210). A heuristic is used to estimate the gaze distance of the viewer. The display frustums are transformed so that they converge at the estimated gaze distance. The images sampled by the cameras (210) are then reprojected into the transformed display frustums. The reprojected images are displayed to the user to simulate viewing of close range objects.

摘要翻译： 公开了用于动态虚拟融合的方法和系统（218）和使用动态虚拟融合的可头戴式显示器（200）的视频。 动态虚拟融合算法（218）包括用两个摄像机对图像进行采样。 摄像机各自具有大于用于显示由照相机（210）采样的图像的显示器的视场的视场。 启发式用于估计观众的凝视距离。 显示平截头体被变形，使得它们在估计的凝视距离处会聚。 然后将由相机（210）采样的图像重新投影到变换的显示平截头体中。 将重新投影的图像显示给用户以模拟近距离对象的观看。

公开(公告)号：US20040222372A1

公开(公告)日：2004-11-11

申请号：US10069894

申请日：2002-02-27

发明人： Michael P. McLoughlin ,  William R. Allmon ,  Charles W. Anderson ,  Micah A. Carlson ,  Nicholas H. Evancich ,  Wayne A. Bryden ,  Scott A. Ecelberger ,  James T. Velky ,  Daniel J. DeCicco ,  Timothy J. Cornish

IPC分类号： H01J049/00

CPC分类号： H01J49/0409 ,  H01J49/0022 ,  H01J49/40 ,  Y10T436/24

摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.

摘要翻译： 一种现场便携式质谱仪系统，包括样品收集器和样品转运器。 样品转运器与样品收集器接口以在其上接收样品沉积物。 该系统还包括飞行时间（TOF）质谱仪。 飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。 该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

公开(公告)号：US20040222370A1

公开(公告)日：2004-11-11

申请号：US10868809

申请日：2004-06-17

发明人： Robert Harold Bateman ,  John Brian Hoyes ,  Jason Lee Wildgoose

IPC分类号： H01J049/00

CPC分类号： H01J49/421 ,  H01J49/0081

摘要： A mass spectrometer includes an ion detector positioned upstream of a quadrupole mass filter/analyser. Ions are passed through the quadrupole mass filter/analyser, stored in an ion trap and then passed back through the same mass filter/analyser before being detected by the upstream ion detector. With this arrangement, MS/MS experiments can be performed using an apparatus having only a single mass filter/analyser.

摘要翻译： 质谱仪包括位于四极质量过滤器/分析器上游的离子检测器。 离子通过四极质量过滤器/分析仪，储存在离子阱中，然后通过相同的质量过滤器/分析仪通过上游离子检测器检测。 利用这种布置，可以使用仅具有单个质量过滤器/分析器的装置来执行MS / MS实验。

公开(公告)号：US20040222369A1

公开(公告)日：2004-11-11

申请号：US10804692

申请日：2004-03-19

申请人： Thermo Finnigan LLC

发明人： Alexander Alekseevich Makarov ,  John Edward Philip Syka

IPC分类号： H01J049/00

CPC分类号： H01J49/063 ,  H01J49/004 ,  H01J49/423

摘要： This invention relates to tandem mass spectrometry and, in particular, to tandem mass spectrometry using a linear ion trap and a time of flight detector to collect mass spectra to form a MS/MS experiment. The accepted standard is to store and mass analyze precursor ions in the ion trap before ejecting the ions axially to a collision cell for fragmentation before mass analysis of the fragments in the time of flight detector. This invention makes use of orthogonal ejection of ions with a narrow range of m/z values to produce a ribbon beam of ions that are injected into the collision cell. The shape of this beam and the high energy of the ions are accommodated by using a planar design of collision cell. Ions are retained in the ion trap during ejection so that successive narrow ranges may be stepped through consecutively to cover all precursor ions of interest.

摘要翻译： 本发明涉及串联质谱法，特别涉及使用线性离子阱和飞行时间检测器的串联质谱法来收集质谱以形成MS / MS实验。 所接受的标准是在离子阱中存储和质量分析前体离子，然后在飞行时间内对碎片进行质量分析之前，将离子轴向排列到碰撞池进行碎裂。 本发明利用具有窄范围m / z值的离子的正交喷射来产生注入到碰撞池中的带状离子束束。 通过使用碰撞池的平面设计来容纳该束的形状和离子的高能量。 在喷射期间离子被保留在离子阱中，使得连续的窄范围可以连续地步进以覆盖所有感兴趣的前体离子。

公开(公告)号：US20040195502A1

公开(公告)日：2004-10-07

申请号：US10401944

申请日：2003-03-31

发明人： Yuichiro Hashimoto ,  Izumi Waki ,  Kiyomi Yoshinari ,  Yasushi Terui ,  Tsukasa Shishika ,  Marvin L. Vestal

IPC分类号： H01J049/00

CPC分类号： H01J49/4205 ,  H01J49/004 ,  H01J49/0481 ,  H01J49/063 ,  H01J49/40

摘要： A mass spectrometer according to the present invention has an ionization source for generating ions; an ion trap for accumulating the ions; a time-of-flight mass spectrometer for performing mass spectrometry analysis on the ions by use of a flight time; a collision damping chamber disposed between the ion trap and the time-of-flight mass spectrometer and having a plurality of electrodes therein, which produce a multi-pole electric field, wherein a gas is introduced into the collision damping chamber to reduce kinetic energy of the ions ejected from the ion trap; and an ion transmission adjusting mechanism disposed between the ion trap and the collision damping chamber to allow or prevent injection of the ions from the ion trap to the collision damping chamber. The mass spectrometer provides greatly enhanced qualitative and quantitative analysis capabilities, as compared with conventional techniques.

摘要翻译： 根据本发明的质谱仪具有用于产生离子的电离源; 用于积聚离子的离子阱; 飞行时间质谱仪，用于通过使用飞行时间对离子进行质谱分析; 设置在离子阱和飞行时间质谱仪之间并且具有多个电极的碰撞阻尼室，其产生多极电场，其中气体被引入到碰撞阻尼室中以降低动能 从离子阱排出的离子; 以及设置在所述离子阱和所述碰撞阻尼室之间的离子透射调节机构，以允许或防止离子从所述离子阱向所述碰撞阻尼室注入。 与常规技术相比，质谱仪提供了大大提高的定性和定量分析能力。

公开(公告)号：US20040178352A1

公开(公告)日：2004-09-16

申请号：US10810396

申请日：2004-03-25

发明人： Patrick D. Perkins

IPC分类号： H01J049/00

CPC分类号： H01J49/10 ,  H01J37/08

摘要： The present invention relates to an ionization source having a chamber for ionizing a sample. The ionization chamber has surfaces to reduce the overall interaction with reactive samples. The inner surface walls of the ionization chamber or the ionization chamber may be formed from an inert super alloy. For instance, Inconelnull 625, Inconelnull 601 or Hastelloynull may comprise the ionization chamber or the surface walls of the ionization chamber. The invention also includes a method for reducing the interaction of a reactive analyte with an ion source.

摘要翻译： 本发明涉及一种具有用于离子化样品的室的电离源。 电离室具有减少与反应性样品的整体相互作用的表面。 电离室或电离室的内表面壁可以由惰性超级合金形成。 例如，Inconel TM 625，Inconel TM 601或Hastelloy可以包括电离室或电离室的表面壁。 本发明还包括减少反应性分析物与离子源的相互作用的方法。

公开(公告)号：US20040173739A1

公开(公告)日：2004-09-09

申请号：US10477270

申请日：2004-04-16

发明人： Myung-Jin Kim ,  Jae-yong Jeon

IPC分类号： H01J049/00

CPC分类号： G01N27/622

摘要： The present invention relates to a radial disk type ion mobility spectrometer, comprising: an ionizing chamber which is made of a cylindrical tube, and includes an inlet for supplying sample gas therethrough, an ionizing means for ionizing the supplied sample gas to generate ions having a predetermined polarity, and a slit formed by cutting away a part of a cylindrical wall corresponding to a predetermined width for discharging the ions therethrough; a shutter grid installed adjacent to the slit of the ionizing chamber for controlling passage of the ions through the slit; a drift chamber which is a hollow tube having a predetermined thickness and including an outer cylindrical wall having a predetermined diameter and an inner cylindrical wall having an inner diameter equal to an outer diameter to the ionizing chamber so that an annular space is formed between the inner and outer cylindrical walls, of which a part of the inner cylindrical wall corresponding to a width larger than that of the slit is cut away such that the ions passing through the slit can be introduced into the annular space through the cutaway part of the inner cylindrical wall, and of which the inner cylindrical wall is engaged with the cylindrical wall of the ionizing chamber in such a manner that the drift chamber communicates with the ionizing chamber through the slit and the cutaway part of the inner cylindrical wall; and a collector installed onto an inner surface of the outer cylindrical wall of the drift chamber for collecting the ions that have passed through the drift chamber.

摘要翻译： 径向盘型离子迁移谱仪本发明涉及一种径向盘式离子迁移谱仪，包括：一个由圆柱形管制成的电离室，包括一个用于提供样品气体的入口，用于使所提供的样品气体离子化的离子化装置， 通过切除与预定宽度对应的圆筒壁的一部分而形成的狭缝，以将离子排出; 安装在电离室狭缝附近的挡板，用于控制离子通过狭缝的通道; 漂移室，其是具有预定厚度的中空管，并且包括具有预定直径的外圆柱形壁和内径等于离子化室的外径的内圆柱形壁，使得在内部 并且外圆柱形壁，其中对应于宽度大于狭缝的宽度的内圆柱形壁的一部分被切掉，使得穿过狭缝的离子可以通过内圆柱体的切口部分被引入环形空间 所述内圆柱壁与所述离子化室的圆筒壁接合，使得所述漂移室通过所述狭缝和所述内圆筒壁的切除部分与所述电离室连通; 以及安装在漂移室的外圆筒壁的内表面上的收集器，用于收集已经通过漂移室的离子。