公开(公告)号：US20170165199A1

公开(公告)日：2017-06-15

申请号：US15277177

申请日：2016-09-27

申请人： University of South Australia

发明人： Clive Allan Prestidge ,  Spomenka SIMOVIC

IPC分类号： A61K9/127 ,  A61K38/00 ,  A61K8/06 ,  A61K8/25 ,  A61K8/55 ,  A61K8/63 ,  A61K47/02 ,  A61K47/24 ,  A61K47/28 ,  A61Q17/04 ,  A61K9/10 ,  A61K8/04 ,  A23L33/115 ,  A23P10/35 ,  A61K31/7088

CPC分类号： A61K9/1271 ,  A23L33/115 ,  A23P10/35 ,  A23V2002/00 ,  A61J3/005 ,  A61J3/02 ,  A61K8/0241 ,  A61K8/04 ,  A61K8/06 ,  A61K8/11 ,  A61K8/25 ,  A61K8/553 ,  A61K8/63 ,  A61K9/10 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/14 ,  A61K9/501 ,  A61K9/5089 ,  A61K9/5115 ,  A61K9/5192 ,  A61K31/7088 ,  A61K38/00 ,  A61K47/02 ,  A61K47/24 ,  A61K47/28 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/651 ,  A61Q17/04 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/22 ,  B82Y5/00

摘要： A method of producing a dried formulation for an active substance such as a drug compound is described. The method involves dispersing a discontinuous phase (e.g. an oil-based or lipidic medium) comprising the active substance into a continuous phase (e.g. water) so as to form a two-phase liquid system comprising droplets of said discontinuous phase, allowing nanoparticles to congregate at the phase interface at the surface of the droplets such that at least one layer of nanoparticles coat the droplets and thereby provide sufficient structural integrity to the droplets to enable the subsequent removal of the continuous phase, and thereafter removing the continuous phase from the nanoparticle-coated droplets to produce a dried formulation.

公开(公告)号：US09662281B2

公开(公告)日：2017-05-30

申请号：US14774855

申请日：2014-03-14

申请人： DSM IP ASSETS B.V.

发明人： Jochen Weiss ,  Christiane Maier ,  Anne Kessler ,  Concetta Tedeschi ,  Bruno Leuenberger ,  Markus Nowotny

IPC分类号： A61K8/02 ,  A61K8/06 ,  A61K47/14 ,  A61K9/10 ,  A61K9/51 ,  A61K8/37 ,  A61Q19/00 ,  A61K8/55 ,  A23K40/30 ,  A23P10/35 ,  A23L27/00

CPC分类号： A61K8/06 ,  A23K40/30 ,  A23L27/72 ,  A23P10/35 ,  A23V2002/00 ,  A61K8/0241 ,  A61K8/37 ,  A61K8/375 ,  A61K8/553 ,  A61K9/10 ,  A61K9/5176 ,  A61K47/14 ,  A61K2800/10 ,  A61K2800/412 ,  A61K2800/652 ,  A61Q19/00

摘要： The present invention relates to new (foodgrade) solid lipid nanoparticles, as well as the production of such solid lipid nanoparticles and the use of them.

公开(公告)号：US20170119674A1

公开(公告)日：2017-05-04

申请号：US15319773

申请日：2015-06-17

申请人： SOLURAL PHARMA APS

发明人： Bent Højgaard

IPC分类号： A61K9/20 ,  A61K9/19 ,  A61K38/12 ,  A61K31/58 ,  A61K31/337 ,  A61K9/00 ,  A61K9/48

CPC分类号： A61K9/2013 ,  A23L33/12 ,  A23P10/20 ,  A23P10/28 ,  A23P10/30 ,  A23P10/35 ,  A61K9/0053 ,  A61K9/1075 ,  A61K9/1611 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/2009 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2095 ,  A61K9/48 ,  A61K9/4808 ,  A61K31/337 ,  A61K31/568 ,  A61K31/58 ,  A61K38/12 ,  A61K47/14 ,  A61K47/44

摘要： The present invention relates to a pharmaceutical composition comprising compound having a log P of at least 5 and a vehicle, wherein the vehicle comprises (a) a fat component in an amount sufficient to achieve lymphatic absorption in a mammal, wherein the fat component is selected from a mono-glyceride of long chain fatty acids, a tri-glyceride of long chain fatty acids, and a mono- and tri-glyceride of long chain fatty acids.

公开(公告)号：US09566237B2

公开(公告)日：2017-02-14

申请号：US13854487

申请日：2013-04-01

申请人： Rutgers, the State University of New Jersey

发明人： Raphael J. Mannino ,  Sara L. Krause-Elsmore ,  Susan Gould-Fogerite ,  David Delmarre ,  Ruying Lu

IPC分类号： A61K9/127 ,  A61K9/107 ,  A61K9/16

CPC分类号： A61K9/127 ,  A23L33/10 ,  A23L33/175 ,  A23P10/35 ,  A61K9/107 ,  A61K9/1274 ,  A61K9/1617

摘要： The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.

摘要翻译： 本发明提供地质输送载体及制造和给药方法。 公开了一种载体，其包括围绕疏水结构域设置的脂质单层，其可以是乳液或其它混合物的一部分，或进一步置于脂质层中。 还公开了一种包括设置在疏水区域周围的脂质层的载体。 该载体可以并入各种药用，食品制剂和个人护理产品中以输送或稳定货物部分。 还考虑了用于稍后添加货物部件的包装运送车辆。

公开(公告)号：US20170000741A1

公开(公告)日：2017-01-05

申请号：US15106476

申请日：2014-12-19

申请人： Fresenius Kabi Deutschland GmbH

发明人： Michael BETZ ,  Edmundo BRITO DE LA FUENTE ,  Crispulo GALLEGOS-MONTES

IPC分类号： A61K9/50 ,  A61K31/19 ,  A23L33/115 ,  B65D51/28 ,  A23L29/10 ,  A23P10/35 ,  B65B7/28 ,  B65D47/06 ,  B01J13/14 ,  A23L29/231

CPC分类号： A61K9/50 ,  A23L29/10 ,  A23L29/231 ,  A23L33/115 ,  A23P10/35 ,  A61K9/16 ,  A61K9/5036 ,  A61K9/5089 ,  A61K31/19 ,  B01J13/14 ,  B65B7/28 ,  B65D47/06 ,  B65D51/28

摘要： The present invention relates to microcapsules and to methods for preparing them. The microcapsules comprise a polymeric coating that is at least partly crosslinked with a polymeric matrix comprising a polysaccharide. In the matrix, a lipid and an active agent or a prodrug or salt thereof are embedded, the lipid preferably having a melting point of at least 30° C. The microcapsules can be used as a medicament, dietary supplement or food additive, the microcapsules comprising a polymeric coating that is at least partly crosslinked with a polymeric matrix comprising a polysaccharide. As above, a lipid and an active agent or a prodrug or salt thereof are embedded in the matrix, with the lipid preferably having a melting point of at least 30° C. Methods for treating diarrhea or preventing colon cancer comprising administering such microcapsules are also disclosed.

摘要翻译： 本发明涉及微胶囊及其制备方法。 微胶囊包含至少部分与包含多糖的聚合物基质部分交联的聚合物涂层。 在基质中，嵌入了脂质和活性剂或其前体药物或其盐，脂质优选具有至少30℃的熔点。微胶囊可用作药物，膳食补充剂或食品添加剂，微胶囊 包括与包含多糖的聚合物基质至少部分交联的聚合物涂层。 如上所述，脂质和活性剂或其前药或盐嵌入基质中，脂质优选具有至少30℃的熔点。治疗腹泻或预防结肠癌的方法包括施用这种微胶囊也是 披露

公开(公告)号：US20160360777A1

公开(公告)日：2016-12-15

申请号：US15246941

申请日：2016-08-25

申请人： Adel PENHASI

发明人： Adel PENHASI

IPC分类号： A23L33/135 ,  A61K9/48 ,  A61K9/50 ,  A61K35/745

CPC分类号： A23L33/135 ,  A21D8/045 ,  A23P10/30 ,  A23P10/35 ,  A23V2002/00 ,  A61K9/4858 ,  A61K9/5015 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5042 ,  A61K9/5073 ,  A61K35/745 ,  A61K2035/115 ,  C12N1/04 ,  A23V2200/3204 ,  A23V2250/0616 ,  A23V2250/5114 ,  A23V2250/636

摘要： A composition comprising probiotic bacteria, the composition comprising: (a) a core composition containing the probiotic bacteria and a stabilizer, wherein the total amount of probiotics in the mixture is from about 10% to about 90% by weight of the core composition; (b) an innermost coating layer, layered on said core composition, comprising at least one hydrophobic solid fat or fatty acid having a melting point lower than 60° C.; (c) an intermediate coating layer layered on said innermost coating layer, which when present in an aqueous solution in the amount of 0.1% weight/weight over the weight of the solution, has a surface tension lower than 60 mN/m, when measured at 25° C.; and (d) an outer coating layer, layered on said intermediate coating layer; wherein the composition is in the form of particles; food products containing the composition and methods of preparation thereof.

公开(公告)号：US20160205991A1

公开(公告)日：2016-07-21

申请号：US15078614

申请日：2016-03-23

申请人： Lemniscate Innovations LLC

发明人： Michael Philip Short ,  Xavier Rene Gonzalez Barrios ,  Argelio A. Maldonado

IPC分类号： B01J13/00 ,  A23L1/052

CPC分类号： A23P10/30 ,  A23L29/20 ,  A23L29/256 ,  A23L29/281 ,  A23L29/284 ,  A23P10/35 ,  B29C48/92

摘要： An apparatus for producing gelled pearls includes: a housing with at least one opening into which a flavored liquid is provided; external components; and internal components. The external components include: a first ingress port through which a first refill pack is coupled; and a dispenser with tubing through which a processed solution is expelled into a gelling bath. The internal components include: a mixing tank for blending the flavored liquid with the first solution; a first flow valve fluidly coupled with the mixing tank and directing the flavored liquid into and out of the mixing tank; a second flow valve fluidly coupled with the mixing tank and directing flow of a proportional amount of the first solution into the mixing tank; and a microcontroller device.

摘要翻译： 一种用于生产凝胶珍珠的装置包括：具有至少一个开口的壳体，其中提供调味液体; 外部元件; 和内部组件。 外部部件包括：第一进料口，第一填充料包通过其连接; 以及具有管道的分配器，将经处理的溶液通过该分配器排出到凝胶浴中。 内部组件包括：用于将调味液体与第一溶液混合的混合罐; 与所述混合罐流体耦合并将调味液体引入和离开所述混合罐的第一流量阀; 与混合罐流体耦合并将比例量的第一溶液的流动引导到混合罐中的第二流量阀; 和微控制器设备。

公开(公告)号：US09333181B2

公开(公告)日：2016-05-10

申请号：US13260168

申请日：2010-03-30

申请人： Jean-Pierre Benoit ,  Thomas Perrier

发明人： Jean-Pierre Benoit ,  Thomas Perrier

IPC分类号： A61K9/20 ,  A61K9/51 ,  A23L1/00 ,  A23L1/30 ,  A61K8/11 ,  A61K8/60 ,  A61K8/64 ,  A61K47/48 ,  A61Q19/00

CPC分类号： A61K9/5123 ,  A23L33/10 ,  A23P10/35 ,  A61K8/11 ,  A61K8/606 ,  A61K8/64 ,  A61K47/6925 ,  A61K2800/413 ,  A61K2800/612 ,  A61Q19/00 ,  Y10T428/2984

摘要： The present invention relates to a liquid lipid core/solid lipid shell capsule surface-functionalized with at least one compound containing at least one amino function, characterized in that the lipid core/lipid shell architecture is on the nanometric scale and in that said compound is covalently bonded to said solid lipid shell via a transacylation reaction. It also relates to a method for preparing such capsules.

摘要翻译： 本发明涉及用至少一种含有至少一个氨基功能的化合物表面官能化的液体脂核心/固体脂壳体胶囊，其特征在于脂质核/脂壳结构在纳米级上，所述化合物是 通过转酰基反应共价键合到所述固体脂壳上。 它还涉及一种制备这种胶囊的方法。

公开(公告)号：US09200164B2

公开(公告)日：2015-12-01

申请号：US13579120

申请日：2011-04-21

申请人： Sylvain Diguet ,  Bruno Leuenberger ,  Fabien Laboulfie ,  Mehrdji Hémati ,  Alain Lamure

发明人： Sylvain Diguet ,  Bruno Leuenberger ,  Fabien Laboulfie ,  Mehrdji Hémati ,  Alain Lamure

IPC分类号： A61K9/20 ,  C09D5/00 ,  A23K1/00 ,  A23L1/00 ,  A23L1/22 ,  A61K9/28

CPC分类号： C09D5/00 ,  A23K40/30 ,  A23L27/72 ,  A23P10/35 ,  A61K9/2853 ,  A61K9/2866

摘要： The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions.

摘要翻译： 本专利申请涉及一种新的涂料体系，具有这种涂料体系的涂料组合物，以及这些组合物在生产食品，饲料，膳食补充剂和/或药物产品中的用途以及食品，饲料 ，膳食补充剂和/或包含这种组合物的药物制品。

公开(公告)号：US20150290131A1

公开(公告)日：2015-10-15

申请号：US14438718

申请日：2013-10-17

申请人： NESTEC S.A.

发明人： Elodie Soussan ,  Francoise Maynard

IPC分类号： A61K9/127 ,  A23L1/00 ,  A23L1/305 ,  A61K9/51 ,  A61K38/17

CPC分类号： A61K9/127 ,  A23L29/10 ,  A23L33/18 ,  A23P10/35 ,  A23V2002/00 ,  A61K9/06 ,  A61K9/5123 ,  A61K38/1709

摘要： Encapsulated bitter peptides, methods of encapsulating bitter peptides, and nutritional compositions including encapsulated bitter peptides are provided. The bitter peptides can be encapsulated in a hydrophobic matrix, such as an organogel, a solid lipid nanoparticle, a liposome or combinations thereof. The encapsulated bitter peptides can be bioavailable, can be selectively encapsulated such that peptides needed for emulsion stabilization are not encapsulated and can maintain encapsulation during further processing such as heat treatment and homogenization.

摘要翻译： 提供了封装的苦味肽，包封苦味肽的方法以及包括封闭苦味肽在内的营养组合物。 苦味肽可以包封在疏水基质中，例如有机凝胶，固体脂质纳米颗粒，脂质体或其组合。 封装的苦味肽可以是生物利用的，可以选择性地包封，使得乳液稳定化所需的肽不被包封，并且可以在进一步加工例如热处理和均化期间保持包封。