知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

253 条记录 (耗时 0.035 秒)

    THERAPEUTIC OR PROPHYLACTIC AGENT, DETECTION METHOD AND DETECTION AGENT FOR METABOLIC SYNDROME, AND METHOD FOR SCREENING OF CANDIDATE COMPOUND FOR THERAPEUTIC AGENT FOR METABOLIC SYNDROME
    72.
    发明申请
    THERAPEUTIC OR PROPHYLACTIC AGENT, DETECTION METHOD AND DETECTION AGENT FOR METABOLIC SYNDROME, AND METHOD FOR SCREENING OF CANDIDATE COMPOUND FOR THERAPEUTIC AGENT FOR METABOLIC SYNDROME 有权
    治疗剂或预防剂，检测方法和代谢综合征检测剂，以及用于代谢综合征治疗药物的候选化合物筛选方法

    公开(公告)号：US20110027187A1

    公开(公告)日：2011-02-03

    申请号：US12734864

    申请日：2008-11-21

    申请人： Takayuki Shindo

    发明人： Takayuki Shindo

    IPC分类号： A61K49/00 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/53 ,  A61P3/00

    CPC分类号： G01N33/6872 ,  A01K67/0276 ,  A01K2217/077 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0375 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/8509 ,  C12Q1/6883 ,  G01N2500/00 ,  G01N2800/04 ,  Y10T436/143333

    摘要： The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.

    摘要翻译： 本发明的目的是提供：代谢综合征的治疗或预防剂，其在生物体中具有改善的稳定性; 和别的。 用于代谢综合征的治疗或预防剂包含编码受体活性修饰蛋白（RAMP）2并选自下述（a）至（d）中的DNA或由DNA编码的多肽作为活性成分的DNA： a）具有SEQ ID NO：1所示核苷酸序列的DNA; （b）在严格条件下具有能够与SEQ ID NO：1所示核苷酸序列杂交的核苷酸序列的DNA; （c）具有编码在SEQ ID NO：2所示的氨基酸序列中具有取代，缺失和/或添加一个或多个氨基酸残基的氨基酸序列的核苷酸序列的DNA; 和（d）具有与SEQ ID NO：1所示核苷酸序列具有90％以上同源性的核苷酸序列的DNA。

    Death domain containing receptor 4
    79.
    发明申请
    Death domain containing receptor 4 有权
    死亡域含受体4

    公开(公告)号：US20080241155A1

    公开(公告)日：2008-10-02

    申请号：US12010108

    申请日：2008-01-18

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  C12N5/06 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07K14/70578 ,  A01K2267/035 ,  C07K16/2878 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。