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    SINGLE MOLECULE DETECTION SYSTEM USING PHOTOBLEACHING INFORMATION
    75.
    发明申请
    SINGLE MOLECULE DETECTION SYSTEM USING PHOTOBLEACHING INFORMATION 有权

    公开(公告)号：US20220128469A1

    公开(公告)日：2022-04-28

    申请号：US17511249

    申请日：2021-10-26

    申请人： Quantum-Si Incorporated

    发明人： Brian Reed ,  Kyle Preston ,  Xinghua Shi ,  Gerard Schmid

    IPC分类号： G01N21/64 ,  G01N33/68

    摘要： Aspects of the present disclosure relate to techniques for calibrating a system comprising integrated device. According to some embodiments, there is provided a method for calibrating a system comprising an integrated device, the method comprising: exciting, with light from at least one excitation source, a reference dye molecule disposed in a chamber of the integrated device; obtaining a signal emitted by the reference dye molecule, the signal containing information representative of a bleaching time of the reference dye molecule; and adjusting one or more characteristics of the system based on the bleaching time of the reference dye molecule.

    SYSTEMS AND METHODS FOR SAMPLE PROCESS SCALING
    76.
    发明申请
    SYSTEMS AND METHODS FOR SAMPLE PROCESS SCALING 有权

    公开(公告)号：US20220128456A1

    公开(公告)日：2022-04-28

    申请号：US17508783

    申请日：2021-10-22

    申请人： Quantum-Si Incorporated

    发明人： Todd Rearick ,  Ali Kabiri ,  Gerard Schmid ,  Kyle Preston

    IPC分类号： G01N21/03 ,  G01N33/68

    摘要： Aspects of the present disclosure relate to methods and systems for increasing the number of samples that can be processed in parallel by an integrated device An integrated device is provided having at least two reaction chambers disposed above an active photodetection area of a single pixel, such that the pixel is sensitive to photons from each of the at least two reaction chambers. In some embodiments, an integrated device may have at least four or more reaction chambers per photodetector. Signals from multiple reaction chambers may be distinguished using any combination of multiplexing techniques including techniques for waveguide multiplexing, intensity multiplexing, and/or lifetime multiplexing. According to further aspects of the technology described herein, there is provided techniques for increasing the amount of sample that can be processed by a single device by reloading an integrated device repeated times to process an increased number of samples by a single device.

    INTEGRATED CIRCUIT WITH SEQUENTIALLY-COUPLED CHARGE STORAGE AND ASSOCIATED TECHNIQUES
    77.
    发明申请
    INTEGRATED CIRCUIT WITH SEQUENTIALLY-COUPLED CHARGE STORAGE AND ASSOCIATED TECHNIQUES 有权

    公开(公告)号：US20220128403A1

    公开(公告)日：2022-04-28

    申请号：US17507596

    申请日：2021-10-21

    申请人： Quantum-Si Incorporated

    发明人： Eric A.G. Webster ,  Todd Rearick ,  Tom Thurston

    IPC分类号： G01J1/44 ,  H01L27/148 ,  H01L27/146 ,  B01J19/00

    摘要： Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit. Some aspects of the present disclosure relate to integrated circuits having pixels with a plurality of charge storage regions. Some aspects of the present disclosure relate to integrated circuits configured to substantially simultaneously collect and read out charge carriers, at least in part. Some aspects of the present disclosure relate to integrated circuits having a plurality of pixels configured to transfer charge carriers between charge storage regions within each pixel substantially at the same time. Some aspects of the present disclosure relate to integrated circuits having three or more sequentially coupled charge storage regions. Some aspects of the present disclosure relate to integrated circuits capable of increased charge transfer rates. Some aspects of the present disclosure relate to techniques for manufacturing and operating integrated circuits according to the other techniques described herein.

    INTEGRATED CIRCUIT WITH SEQUENTIALLY-COUPLED CHARGE STORAGE AND ASSOCIATED TECHNIQUES
    78.
    发明申请
    INTEGRATED CIRCUIT WITH SEQUENTIALLY-COUPLED CHARGE STORAGE AND ASSOCIATED TECHNIQUES 有权

    公开(公告)号：US20220128402A1

    公开(公告)日：2022-04-28

    申请号：US17507585

    申请日：2021-10-21

    申请人： Quantum-Si Incorporated

    发明人： Eric A.G. Webster ,  Todd Rearick ,  Tom Thurston

    IPC分类号： G01J1/44 ,  H01L27/148 ,  B01J19/00

    摘要： Described herein are techniques that improve the collection and readout of charge carriers in an integrated circuit. Some aspects of the present disclosure relate to integrated circuits having pixels with a plurality of charge storage regions. Some aspects of the present disclosure relate to integrated circuits configured to substantially simultaneously collect and read out charge carriers, at least in part. Some aspects of the present disclosure relate to integrated circuits having a plurality of pixels configured to transfer charge carriers between charge storage regions within each pixel substantially at the same time. Some aspects of the present disclosure relate to integrated circuits having three or more sequentially coupled charge storage regions. Some aspects of the present disclosure relate to integrated circuits capable of increased charge transfer rates. Some aspects of the present disclosure relate to techniques for manufacturing and operating integrated circuits according to the other techniques described herein.

    INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES
    79.
    发明申请
    INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES 有权

    公开(公告)号：US20220099575A1

    公开(公告)日：2022-03-31

    申请号：US17497835

    申请日：2021-10-08

    申请人： Quantum-Si Incorporated

    发明人： Jonathan M. Rothberg ,  Ali Kabiri ,  Jason W. Sickler ,  Brett J. Gyarfas ,  Jeremy Lackey ,  Gerard Schmid ,  Lawrence C. West ,  Keith G. Fife ,  Benjamin Cipriany ,  Farshid Ghasemi

    IPC分类号： G01N21/64 ,  C12Q1/6874 ,  C12Q1/6869

    摘要： System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device. One of multiple markers distinguishable by temporal parameters of the emission energy may label the sample and configuration of the sensor within a pixel may allow for detection of a temporal parameter associated with the marker labeling the sample.